(Q24312811)

cholesterol 24-hydroxylase activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

6

Irina A Pikuleva

Irina A

Pikuleva

1 reference

19 October 2023

3

Ingemar Bjorkhem

Ingemar

Bjorkhem

1 reference

19 October 2023

Natalia Mast

1

Natalia

Mast

1 reference

19 October 2023

Mark Andrew White

series ordinal

2

author given names

Mark Andrew

author last names

White

1 reference

19 October 2023

Eric F Johnson

series ordinal

4

author given names

Eric F

author last names

Johnson

1 reference

19 October 2023

C David Stout

series ordinal

5

author given names

C David

author last names

Stout

1 reference

Proceedings of the National Academy of Sciences of the United States of America

19 October 2023

language of work or name

English

0 references

publication date

15 July 2008

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published in

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volume

105

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issue

28

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page(s)

9546-51

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cites work

Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474539

cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474539

Crystal structures of metyrapone- and phenylimidazole-inhibited complexes of cytochrome P-450cam

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474539

Detection, delineation, measurement and display of cavities in macromolecular structures

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474539

Structure validation by Calpha geometry: phi,psi and Cbeta deviation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474539

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

19 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474539

19 March 2017

https://api.crossref.org/works/10.1073/PNAS.0803717105

Convergence of genes implicated in Alzheimer's disease on the cerebral cholesterol shuttle: APP, cholesterol, lipoproteins, and atherosclerosis

22 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474539

Cholesterol-metabolizing cytochromes P450

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474539

Expression of human cytochrome P450 46A1 in Escherichia coli: effects of N- and C-terminal modifications

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474539

Differential expression of cholesterol hydroxylases in Alzheimer's disease

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474539

Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474539

On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474539

Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474539

De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474539

Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474539

Use of complementary cation and anion heavy-atom salt derivatives to solve the structure of cytochrome P450 46A1

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474539

Regulation of alpha- and beta-secretase activity by oxysterols: cerebrosterol stimulates processing of APP via the alpha-secretase pathway

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474539

Use of simple docking methods to screen a virtual library for heteroactivators of cytochrome P450 2C9.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474539

Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474539

Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474539

Cholesterol metabolism in the brain: importance of 24S-hydroxylation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474539

Brain cholesterol turnover required for geranylgeraniol production and learning in mice

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474539

Cholesterol and apolipoprotein E in Alzheimer's disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474539

The structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0-A resolution

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474539

Brain cholesterol: long secret life behind a barrier.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474539

Cholesterol and the biology of Alzheimer's disease.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474539

Cholesterol metabolism in the brain

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474539

Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474539

Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls

30 May 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0803717105

Altered levels of plasma 24S- and 27-hydroxycholesterol in demented patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0803717105

24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0803717105

Identification of 24-hydroxycholesterol in bovine adrenals in both free and esterified forms and in bovine brains as its sulfate ester.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0803717105

Dapsone activation of CYP2C9-mediated metabolism: evidence for activation of multiple substrates and a two-site model

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474539

Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients

29 November 2018

1 reference

12 December 2020

Interactions of nitrogen heterocycles with cytochrome P-450 and monooxygenase activity

1 reference

12 December 2020

Spectroscopic investigations of ferric cytochrome P-450-CAM ligand complexes. Identification of the ligand trans to cysteinate in the native enzyme

1 reference

12 December 2020

Pharmacokinetics of tranylcypromine in patients who are depressed: relationship to cardiovascular effects

1 reference

12 December 2020

release_lcdp3p57yvdptivcceteu2adme

Identifiers

DOI

10.1073/PNAS.0803717105

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ADS bibcode

2008PNAS..105.9546M

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Fatcat ID

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PMC publication ID

2474539

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