(Q24314243)

English

Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids

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scholarly article

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Europe PubMed Central

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14 January 2020

Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18801738%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

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transmembrane protein

0 references

Free fatty acid receptor 2

1 reference

GOA release 2020-03-11

Free fatty acid receptor 3

1 reference

GOA release 2020-03-11

cellular response to fatty acid

1 reference

GOA release 2020-03-11

Leigh A Stoddart

1

1 reference

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14 January 2020

2

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14 January 2020

4

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14 January 2020

author name string

Laura Jenkins

3

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14 January 2020

Graeme Milligan

5

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14 January 2020

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publication date

18 September 2008

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14 January 2020

Journal of Biological Chemistry

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14 January 2020

283

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14 January 2020

32913-32924

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14 January 2020

47

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14 January 2020

Synthesis and activity of small molecule GPR40 agonists.

1 reference

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7 January 2021

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G protein-coupled receptors for free fatty acids.

1 reference

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7 January 2021

based on heuristic

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The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse

1 reference

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7 January 2021

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Techniques: promiscuous Galpha proteins in basic research and drug discovery

1 reference

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7 January 2021

based on heuristic

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Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805601200

7 January 2021

based on heuristic

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Chimaeric G alpha proteins: their potential use in drug discovery

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805601200

7 January 2021

based on heuristic

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Residues from transmembrane helices 3 and 5 participate in leukotriene B4 binding to BLT1

1 reference

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7 January 2021

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Comparative analysis of the efficacy of A1 adenosine receptor activation of Gi/o alpha G proteins following coexpression of receptor and G protein and expression of A1 adenosine receptor-Gi/o alpha fusion proteins

1 reference

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7 January 2021

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CCR2: characterization of the antagonist binding site from a combined receptor modeling/mutagenesis approach

1 reference

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7 January 2021

based on heuristic

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Bidirectional, iterative approach to the structural delineation of the functional "chemoprint" in GPR40 for agonist recognition

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805601200

7 January 2021

based on heuristic

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Synthesis and biological evaluation of 3-aryl-3-(4-phenoxy)-propionic acid as a novel series of G protein-coupled receptor 40 agonists

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805601200

7 January 2021

based on heuristic

inferred from DOI database lookup

Discovery of novel agonists and antagonists of the free fatty acid receptor 1 (FFAR1) using virtual screening

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805601200

7 January 2021

based on heuristic

inferred from DOI database lookup

Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805601200

7 January 2021

based on heuristic

inferred from DOI database lookup

Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805601200

7 January 2021

based on heuristic

inferred from DOI database lookup

Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805601200

7 January 2021

based on heuristic

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Gi3 does not contribute to the inhibition of adenylate cyclase when stimulation of an α2-adrenergic receptor causes activation of both Gi2 and Gi3

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805601200

7 January 2021

based on heuristic

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The G-protein-coupled receptor 40 family (GPR40-GPR43) and its role in nutrient sensing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805601200

7 January 2021

based on heuristic

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Effective information transfer from the alpha 1b-adrenoceptor to Galpha 11 requires both beta/gamma interactions and an aromatic group four amino acids from the C terminus of the G protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805601200

7 January 2021

based on heuristic

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The unique ligand-binding pocket for the human prostacyclin receptor. Site-directed mutagenesis and molecular modeling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805601200

7 January 2021

based on heuristic

inferred from DOI database lookup

The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805601200

7 January 2021

based on heuristic

inferred from DOI database lookup

The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805601200

7 January 2021

based on heuristic

inferred from DOI database lookup

Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805601200

7 January 2021

based on heuristic

inferred from DOI database lookup

A novel Galphaq/11-selective inhibitor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805601200

7 January 2021

based on heuristic

inferred from DOI database lookup

Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805601200

7 January 2021

based on heuristic

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Orexin-1 receptor-cannabinoid CB1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805601200

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of residues important for agonist recognition and activation in GPR40

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805601200

7 January 2021

based on heuristic

inferred from DOI database lookup

Constitutive activity of the cannabinoid CB1 receptor regulates the function of co-expressed Mu opioid receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805601200

7 January 2021

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Seven transmembrane-spanning receptors for free fatty acids as therapeutic targets for diabetes mellitus: pharmacological, phylogenetic, and drug discovery aspects.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805601200

7 January 2021

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Functional assays as prismatic views of drug activity: relevance to new drug discovery

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805601200

7 January 2021

based on heuristic

inferred from DOI database lookup

A family of fatty acid binding receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805601200

7 January 2021

based on heuristic

inferred from DOI database lookup

A highly conserved glycine within linker I and the extreme C terminus of G protein alpha subunits interact cooperatively in switching G protein-coupled receptor-to-effector specificity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805601200

7 January 2021

based on heuristic

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Characterization of determinants of ligand binding to the nicotinic acid receptor GPR109A (HM74A/PUMA-G).

1 reference

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7 January 2021

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Interactions between the Mas-related receptors MrgD and MrgE alter signalling and trafficking of MrgD.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805601200

7 January 2021

based on heuristic

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Uncovering the pharmacology of the G protein-coupled receptor GPR40: high apparent constitutive activity in guanosine 5'-O-(3-[35S]thio)triphosphate binding studies reflects binding of an endogenous agonist

1 reference

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7 January 2021

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Protean agonism at the dopamine D2 receptor: (S)-3-(3-hydroxyphenyl)-N-propylpiperidine is an agonist for activation of Go1 but an antagonist/inverse agonist for Gi1,Gi2, and Gi3.

1 reference

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7 January 2021

based on heuristic

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Functional selectivity through protean and biased agonism: who steers the ship?

1 reference

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Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice

1 reference

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Identifiers

10.1074/JBC.M805601200

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18801738%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18801738%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

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