(Q24315631)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0070576

cytochrome P450 family 3 subfamily A member 4

GOA release 2020-03-11

1 reference

cytochrome P450 family 1 subfamily A member 1

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Ram P Gupta

1

0 references

You Ai He

2

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Kennerly S Patrick

3

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James R Halpert

4

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Norman H Bell

The Journal of Clinical Endocrinology and Metabolism

5

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language of work or name

English

0 references

publication date

February 2005

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published in

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volume

90

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issue

2

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page(s)

1210-9

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describes a project that uses

site-directed mutagenesis

1 reference

Effects of increasing doses of 1 alpha-hydroxyvitamin D2 on calcium homeostasis in postmenopausal osteopenic women

inferred from title

cites work

1 reference

https://api.crossref.org/works/10.1210%2FJC.2004-0966

7 January 2021

Reconstitution premixes for assays using purified recombinant human cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b5.

1 reference

https://api.crossref.org/works/10.1210%2FJC.2004-0966

7 January 2021

Structure-function analysis of human cytochrome P450 3A4 using 7-alkoxycoumarins as active-site probes

1 reference

https://api.crossref.org/works/10.1210%2FJC.2004-0966

7 January 2021

Interindividual differences in hepatic expression of CYP3A4: relationship to genetic polymorphism in the 5'-upstream regulatory region

1 reference

https://api.crossref.org/works/10.1210%2FJC.2004-0966

7 January 2021

Measurement of protein using bicinchoninic acid

1 reference

https://api.crossref.org/works/10.1210%2FJC.2004-0966

7 January 2021

Analysis of homotropic and heterotropic cooperativity of diazepam oxidation by CYP3A4 using site-directed mutagenesis and kinetic modeling

1 reference

https://api.crossref.org/works/10.1210%2FJC.2004-0966

7 January 2021

Comparison of the relative effects of 1,24-dihydroxyvitamin D(2) [1, 24-(OH)(2)D(2)], 1,24-dihydroxyvitamin D(3) [1,24-(OH)(2)D(3)], and 1,25-dihydroxyvitamin D(3) [1,25-(OH)(2)D(3)] on selected vitamin D-regulated events in the rat.

1 reference

https://api.crossref.org/works/10.1210%2FJC.2004-0966

7 January 2021

Pharmacokinetics and systemic effect on calcium homeostasis of 1 alpha,24-dihydroxyvitamin D2 in rats. Comparison with 1 alpha,25-dihydroxyvitamin D2, calcitriol, and calcipotriol

1 reference

https://api.crossref.org/works/10.1210%2FJC.2004-0966

7 January 2021

Development of a comprehensive panel of antibodies against the major xenobiotic metabolising forms of cytochrome P450 in humans

1 reference

https://api.crossref.org/works/10.1210%2FJC.2004-0966

7 January 2021

A possible genetic defect in 25-hydroxylation as a cause of rickets

1 reference

https://api.crossref.org/works/10.1210%2FJC.2004-0966

7 January 2021

A new pathway of 25-hydroxyvitamin D3 metabolism

1 reference

https://api.crossref.org/works/10.1210%2FJC.2004-0966

7 January 2021

1 alpha-hydroxylation of 24-hydroxyvitamin D2 represents a minor physiological pathway for the activation of vitamin D2 in mammals

1 reference

https://api.crossref.org/works/10.1210%2FJC.2004-0966

7 January 2021

Phenylalanine and tryptophan scanning mutagenesis of CYP3A4 substrate recognition site residues and effect on substrate oxidation and cooperativity

1 reference

https://api.crossref.org/works/10.1210%2FJC.2004-0966

7 January 2021

Cooperativity in oxidations catalyzed by cytochrome P450 3A4.

1 reference

https://api.crossref.org/works/10.1210%2FJC.2004-0966

7 January 2021

1α,24(S)-dihydroxyvitamin D2: a biologically active product of 1α-hydroxyvitamin D2 made in the human hepatoma, Hep3B

1 reference

https://api.crossref.org/works/10.1210%2FJC.2004-0966

7 January 2021

Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase

1 reference

https://api.crossref.org/works/10.1210%2FJC.2004-0966

7 January 2021

Transfected human liver cytochrome P-450 hydroxylates vitamin D analogs at different side-chain positions

1 reference

https://api.crossref.org/works/10.1210%2FJC.2004-0966

7 January 2021

Alanine-scanning mutagenesis of a putative substrate recognition site in human cytochrome P450 3A4. Role of residues 210 and 211 in flavonoid activation and substrate specificity

1 reference

https://api.crossref.org/works/10.1210%2FJC.2004-0966

7 January 2021

Porcine microsomal vitamin D(3) 25-hydroxylase (CYP2D25). Catalytic properties, tissue distribution, and comparison with human CYP2D6.

1 reference

https://api.crossref.org/works/10.1210%2FJC.2004-0966

7 January 2021

De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase

1 reference

https://api.crossref.org/works/10.1210%2FJC.2004-0966

7 January 2021

Assessment of specificity of eight chemical inhibitors using cDNA-expressed cytochromes P450.

1 reference

https://api.crossref.org/works/10.1210%2FJC.2004-0966

7 January 2021

Quantification of multiple human cytochrome P450 mRNA molecules using competitive reverse transcriptase-PCR.

1 reference

https://api.crossref.org/works/10.1210%2FJC.2004-0966

7 January 2021

Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver

1 reference

https://api.crossref.org/works/10.1210%2FJC.2004-0966

7 January 2021

Identification and functional characterization of eight CYP3A4 protein variants

1 reference

https://api.crossref.org/works/10.1210%2FJC.2004-0966

7 January 2021

Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control.

1 reference

https://api.crossref.org/works/10.1210%2FJC.2004-0966

7 January 2021

Midazolam oxidation by cytochrome P450 3A4 and active-site mutants: an evaluation of multiple binding sites and of the metabolic pathway that leads to enzyme inactivation

1 reference

https://api.crossref.org/works/10.1210%2FJC.2004-0966

7 January 2021

Inhibition of cytochrome P450 (CYP450) isoforms by isoniazid: potent inhibition of CYP2C19 and CYP3A

1 reference

https://api.crossref.org/works/10.1210%2FJC.2004-0966

7 January 2021

CYP3A4 is a human microsomal vitamin D 25-hydroxylase

1 reference

https://api.crossref.org/works/10.1210%2FJC.2004-0966

7 January 2021

Cytochrome P450 3A: ontogeny and drug disposition

1 reference

https://api.crossref.org/works/10.1210%2FJC.2004-0966

7 January 2021

Specificity of substrate and inhibitor probes for cytochrome P450s: evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes

1 reference

https://api.crossref.org/works/10.1210%2FJC.2004-0966

7 January 2021