(Q424440)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08684

cytochrome P450, E-class, CYP3A

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08684

cytochrome P450, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

16 January 2019

1 reference

16 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

1 reference

8 April 2019

heme binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

1 reference

8 April 2019

caffeine oxidase activity

1 reference

8 April 2019

The relative contribution of human cytochrome P450 isoforms to the four caffeine oxidation pathways: an in vitro comparative study with cDNA-expressed P450s including CYP2C isoforms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

testosterone 6-beta-hydroxylase activity

1 reference

8 April 2019

Human liver microsomal steroid metabolism: identification of the major microsomal steroid hormone 6 beta-hydroxylase cytochrome P-450 enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

1 reference

8 April 2019

steroid binding

1 reference

8 April 2019

Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

vitamin D3 25-hydroxylase activity

1 reference

8 April 2019

CYP3A4 is a vitamin D-24- and 25-hydroxylase: analysis of structure function by site-directed mutagenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

steroid hydroxylase activity

1 reference

8 April 2019

Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

vitamin D 24-hydroxylase activity

1 reference

8 April 2019

CYP3A4 is a vitamin D-24- and 25-hydroxylase: analysis of structure function by site-directed mutagenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

enzyme binding

IPI

1 reference

8 April 2019

Interactions of mammalian cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b(5) enzymes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

IPI

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

1 reference

8 April 2019

monooxygenase activity

Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

8 April 2019

8 April 2019

Characterization of human cytochrome P450 enzymes catalyzing domperidone N-dealkylation and hydroxylation in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

oxidoreductase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

4 references

8 April 2019

8 April 2019

Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

8 April 2019

Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

8 April 2019

Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

estrogen 16-alpha-hydroxylase activity

1 reference

8 April 2019

Human cytochrome P450 3A7 has a distinct high catalytic activity for the 16alpha-hydroxylation of estrone but not 17beta-estradiol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

cell component

cytoplasm

1 reference

8 April 2019

An NH2-terminal truncated cytochrome P450 CYP3A4 showing catalytic activity is present in the cytoplasm of human liver cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

integral component of membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

1 reference

8 April 2019

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

1 reference

8 April 2019

endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

1 reference

8 April 2019

organelle membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

1 reference

8 April 2019

xenobiotic metabolic process

biological process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

1 reference

8 April 2019

heterocycle metabolic process

1 reference

8 April 2019

Characterization of human cytochrome P450 enzymes catalyzing domperidone N-dealkylation and hydroxylation in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

oxidative demethylation

2 references

8 April 2019

Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

8 April 2019

The relative contribution of human cytochrome P450 isoforms to the four caffeine oxidation pathways: an in vitro comparative study with cDNA-expressed P450s including CYP2C isoforms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

monoterpenoid metabolic process

1 reference

8 April 2019

Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

steroid catabolic process

1 reference

8 April 2019

Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

androgen metabolic process

1 reference

8 April 2019

Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

alkaloid catabolic process

1 reference

8 April 2019

Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

vitamin D metabolic process

IC

1 reference

8 April 2019

CYP3A4 is a vitamin D-24- and 25-hydroxylase: analysis of structure function by site-directed mutagenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

calcitriol biosynthetic process from calciol

IC

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

lipid hydroxylation

1 reference

8 April 2019

Human cytochrome P450 3A7 has a distinct high catalytic activity for the 16alpha-hydroxylation of estrone but not 17beta-estradiol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

steroid metabolic process

Human liver microsomal steroid metabolism: identification of the major microsomal steroid hormone 6 beta-hydroxylase cytochrome P-450 enzyme

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

8 April 2019

8 April 2019

Human cytochrome P450 3A7 has a distinct high catalytic activity for the 16alpha-hydroxylation of estrone but not 17beta-estradiol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

long-chain fatty acid biosynthetic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08684

1 reference

8 April 2019

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7247

IUPHAR/BPS Guide to PHARMACOLOGY

17 August 2016

1 reference

Guide to Pharmacology Ligand ID

8804

IUPHAR/BPS Guide to PHARMACOLOGY

17 August 2016

1 reference

Guide to Pharmacology Ligand ID

2406

English

http://www.uniprot.org/uniprot/P08684.txt?version=182

17 August 2016

EC enzyme number

1.14.13.32

1 reference

12 January 2016

Gene Atlas image

PBB GE TNFRSF11B 204932 at tn.png
255 × 135; 824 bytes

1 reference

imported from Wikimedia project

English Wikipedia

exact match

http://purl.uniprot.org/uniprot/P08684

1 reference

cytochrome P450, conserved site

Identifiers.org

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08684

Identifiers

1 reference

8 February 2019

1 reference

8 February 2019

1 reference

16 January 2019

1 reference

1 reference

1 reference

1 reference

28 October 2013

Microsoft Academic ID

0 references

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016