(Q24317542)

English

A widely expressed transcription factor with multiple DNA sequence specificity, CTCF, is localized at chromosome segment 16q22.1 within one of the smallest regions of overlap for common deletions in breast and prostate cancers

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scholarly article

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A widely expressed transcription factor with multiple DNA sequence specificity, CTCF, is localized at chromosome segment 16q22.1 within one of the smallest regions of overlap for common deletions in breast and prostate cancers (English)

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CCCTC-binding factor

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GOA release 2020-03-11

DNA-binding transcription factor activity

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GOA release 2020-03-11

prostate cancer

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based on heuristic

inferred from title

Annika Lindblom

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object named as

A Lindblom

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author name string

G N Filippova

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L J Meincke

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E M Klenova

4

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P E Neiman

5

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S J Collins

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N A Doggett

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V V Lobanenkov

8

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language of work or name

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publication date

May 1998

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Genes, Chromosomes and Cancer

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22

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26-36

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1

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Negative protein 1, which is required for function of the chicken lysozyme gene silencer in conjunction with hormone receptors, is identical to the multivalent zinc finger repressor CTCF.

1 reference

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An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes

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Allelic loss of chromosome 16q in endometrial cancer: correlation with poor prognosis of patients and less differentiated histology.

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CTCF, a conserved nuclear factor required for optimal transcriptional activity of the chicken c-myc gene, is an 11-Zn-finger protein differentially expressed in multiple forms

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Transcriptional down-regulation of c-myc in human prostate carcinoma cells by the synthetic androgen mibolerone

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Genomic alterations in human breast carcinomas

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At least two different regions are involved in allelic imbalance on chromosome arm 16q in breast cancer

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High frequency of allelic imbalance at chromosome region 16q22-23 in human breast cancer: correlation with high PgR and low S phase

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Transcriptional activation by Myc is under negative control by the transcription factor AP-2

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Loss of heterozygosity on chromosome arm 16q in breast cancer metastases.

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1 reference

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Identifiers

10.1002/(SICI)1098-2264(199805)22:1<26::AID-GCC4>3.0.CO;2-9

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