(Q5014546)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P49711

Zinc finger C2H2-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

image

Protein CTCF PDB 1x6h.png
628 × 540; 107 KB

0 references

1 reference

13 November 2019

1 reference

13 November 2019

transcription corepressor activity

1 reference

8 April 2019

An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

DNA-binding transcription factor activity

TAS

2 references

27 March 2018

A widely expressed transcription factor with multiple DNA sequence specificity, CTCF, is localized at chromosome segment 16q22.1 within one of the smallest regions of overlap for common deletions in breast and prostate cancers

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49711&geneProductId=UniProtKB:P49711

27 March 2018

An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49711&geneProductId=UniProtKB:P49711

1 reference

8 April 2019

An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

chromatin insulator sequence binding

1 reference

8 April 2019

Critical DNA binding interactions of the insulator protein CTCF: a small number of zinc fingers mediate strong binding, and a single finger-DNA interaction controls binding at imprinted loci

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

8 April 2019

An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

DNA-binding transcription repressor activity, RNA polymerase II-specific

2 references

10 September 2018

An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49711&geneProductId=UniProtKB:P49711

8 April 2019

An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

6 references

8 April 2019

Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

8 April 2019

CTCF Recruits Centromeric Protein CENP-E to the Pericentromeric/Centromeric Regions of Chromosomes through Unusual CTCF-Binding Sites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

8 April 2019

JARID1B is a luminal lineage-driving oncogene in breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

8 April 2019

The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

8 April 2019

Vigilin interacts with CCCTC-binding factor (CTCF) and is involved in CTCF-dependent regulation of the imprinted genes Igf2 and H19

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

sequence-specific DNA binding

1 reference

27 March 2018

Critical DNA binding interactions of the insulator protein CTCF: a small number of zinc fingers mediate strong binding, and a single finger-DNA interaction controls binding at imprinted loci

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49711&geneProductId=UniProtKB:P49711

DNA-binding transcription activator activity, RNA polymerase II-specific

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

DNA-binding transcription factor activity

3 references

8 April 2019

A widely expressed transcription factor with multiple DNA sequence specificity, CTCF, is localized at chromosome segment 16q22.1 within one of the smallest regions of overlap for common deletions in breast and prostate cancers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

8 April 2019

An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

4 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49711&geneProductId=UniProtKB:P49711

27 March 2018

CTCF binding and higher order chromatin structure of the H19 locus are maintained in mitotic chromatin

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49711&geneProductId=UniProtKB:P49711

27 March 2018

Targeting of CTCF to the nucleolus inhibits nucleolar transcription through a poly(ADP-ribosyl)ation-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49711&geneProductId=UniProtKB:P49711

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49711&geneProductId=UniProtKB:P49711

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

1 reference

8 April 2019

Targeting of CTCF to the nucleolus inhibits nucleolar transcription through a poly(ADP-ribosyl)ation-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

chromosome, centromeric region

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

8 April 2019

CTCF Recruits Centromeric Protein CENP-E to the Pericentromeric/Centromeric Regions of Chromosomes through Unusual CTCF-Binding Sites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

8 April 2019

CTCF physically links cohesin to chromatin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

1 reference

8 April 2019

CTCF binding and higher order chromatin structure of the H19 locus are maintained in mitotic chromatin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

8 April 2019

CTCF genetic alterations in endometrial carcinoma are pro-tumorigenic.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

8 April 2019

The zinc finger protein CTCF binds to the APBbeta domain of the amyloid beta-protein precursor promoter. Evidence for a role in transcriptional activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

8 April 2019

CTCF binding and higher order chromatin structure of the H19 locus are maintained in mitotic chromatin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

8 April 2019

Targeting of CTCF to the nucleolus inhibits nucleolar transcription through a poly(ADP-ribosyl)ation-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

regulation of transcription, DNA-templated

IBA

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

regulation of gene expression, epigenetic

1 reference

8 April 2019

CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

regulation of centromeric sister chromatid cohesion

1 reference

8 April 2019

CTCF physically links cohesin to chromatin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

NAS

chromosome segregation

1 reference

8 April 2019

transcription, DNA-templated

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49711&geneProductId=UniProtKB:P49711

positive regulation of transcription, DNA-templated

negative regulation of transcription, DNA-templated

2 references

8 April 2019

DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

8 April 2019

An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

protein localization to chromosome, centromeric region

1 reference

8 April 2019

CTCF Recruits Centromeric Protein CENP-E to the Pericentromeric/Centromeric Regions of Chromosomes through Unusual CTCF-Binding Sites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

negative regulation of cell population proliferation

1 reference

8 April 2019

CTCF genetic alterations in endometrial carcinoma are pro-tumorigenic.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

chromatin organization

1 reference

8 April 2019

negative regulation of transcription by RNA polymerase II

1 reference

27 March 2018

An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49711&geneProductId=UniProtKB:P49711

positive regulation of gene expression

1 reference

27 March 2018

The insulator factor CTCF controls MHC class II gene expression and is required for the formation of long-distance chromatin interactions

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49711&geneProductId=UniProtKB:P49711

negative regulation of transcription by RNA polymerase II

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

8 April 2019

An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

regulation of gene expression by genetic imprinting

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

maintenance of DNA methylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

negative regulation of gene expression

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

regulation of histone methylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

regulation of histone acetylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

positive regulation of transcription by RNA polymerase II

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49711

http://purl.uniprot.org/uniprot/P49711

IBA

Gene Atlas image

PBB GE CTCF 202521 at fs.png
732 × 530; 11 KB

0 references

exact match

1 reference

Identifiers.org

has part(s)

Zinc finger C2H2-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P49711

Identifiers

MeSH descriptor ID

D000076246

subject named as

CCCTC-Binding Factor

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1 reference

30 May 2020

1 reference

30 May 2020

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30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

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1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

4 August 2016

language of work or name

1 reference

4 August 2016

language of work or name

1 reference

inferred by common MeSH mappings on source and on Wikidata