(Q24318310)

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Association of the insulin receptor with phospholipase C-gamma (PLCgamma) in 3T3-L1 adipocytes suggests a role for PLCgamma in metabolic signaling by insulin

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Association of the insulin receptor with phospholipase C-gamma (PLCgamma) in 3T3-L1 adipocytes suggests a role for PLCgamma in metabolic signaling by insulin (English)

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Peter Vollenweider

6

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Jerrold M. Olefsky

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J M Olefsky

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author name string

A G Kayali

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J Eichhorn

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T Haruta

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A J Morris

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J G Nelson

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N J Webster

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publication date

29 May 1998

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Journal of Biological Chemistry

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273

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13808-18

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22

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Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

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21 January 2018

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

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21 January 2018

Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin

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21 January 2018

Insulin-stimulated GLUT4 translocation is mediated by a divergent intracellular signaling pathway

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21 January 2018

The role of protein kinase C in insulin action

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21 January 2018

Insulin-stimulated glucose transport in muscle. Evidence for a protein-kinase-C-dependent component which is unaltered in insulin-resistant mice

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21 January 2018

Identification of a major defect in insulin-resistant tissues of genetically obese (fa/fa) rats. Impaired protein kinase C.

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21 January 2018

Decreased insulin responsiveness in fat cells rendered protein kinase C-deficient by a treatment with a phorbol ester

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21 January 2018

Insulin-sensitive phospholipid signaling systems and glucose transport: an update

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21 January 2018

Crosstalk among multiple signal-activated phospholipases

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21 January 2018

Regulation of phosphoinositide-specific phospholipase C isozymes

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Selectivity of phospholipase C phosphorylation by the epidermal growth factor receptor, the insulin receptor, and their cytoplasmic domains

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Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development

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Extending the C2 domain family: C2s in PKCs delta, epsilon, eta, theta, phospholipases, GAPs, and perforin

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21 January 2018

Biosynthetic labeling of insulin receptor: studies of subunits in cultured human IM-9 lymphocytes

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Enhancement of epidermal growth factor (EGF) and insulin-stimulated tyrosine phosphorylation of endogenous substrates by sodium selenate

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21 January 2018

Neuraminidase treatment of isolated rat adipocytes and differential regulation of basal and insulin-stimulated glucose transport

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21 January 2018

The function of GRB2 in linking the insulin receptor to Ras signaling pathways

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21 January 2018

Immunocytochemical localization of phospholipase C-gamma in rat embryo fibroblasts

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21 January 2018

Dissociation of tyrosine phosphorylation and activation of phosphoinositide phospholipase C induced by the protein kinase C inhibitor Ro-31-8220 in Swiss 3T3 cells treated with platelet-derived growth factor

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21 January 2018

Activation of phospholipase C-gamma by the concerted action of tau proteins and arachidonic acid

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21 January 2018

A phospholipase C inhibitor, U-73122, blocks TSH-induced inositol trisphosphate production, Ca2+ increase and arachidonic acid release in FRTL-5 thyroid cells

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21 January 2018

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

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21 January 2018

A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

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21 January 2018

Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP.

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21 January 2018

Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation

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21 January 2018

Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

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21 January 2018

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

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21 January 2018

Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin

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21 January 2018

Roles of 1-phosphatidylinositol 3-kinase and ras in regulating translocation of GLUT4 in transfected rat adipose cells

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21 January 2018

Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression

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21 January 2018

Protein kinase C alpha activates RAF-1 by direct phosphorylation

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21 January 2018

Implications of the SNARE hypothesis for intracellular membrane topology and dynamics

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The molecular machinery for secretion is conserved from yeast to neurons

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The synaptic vesicle cycle: a cascade of protein-protein interactions

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Effects of the phospholipase-C inhibitor, U73122, on signaling and secretion in pituitary gonadotrophs

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Essential role for diacylglycerol in protein transport from the yeast Golgi complex.

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Moving GLUT4: the biogenesis and trafficking of GLUT4 storage vesicles

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Syntaxin 4 in 3T3-L1 adipocytes: regulation by insulin and participation in insulin-dependent glucose transport

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21 January 2018

Cellubrevin is a resident protein of insulin-sensitive GLUT4 glucose transporter vesicles in 3T3-L1 adipocytes

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21 January 2018

The glucose transporter (GLUT-4) and vesicle-associated membrane protein-2 (VAMP-2) are segregated from recycling endosomes in insulin-sensitive cells

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21 January 2018

Syntaxin 4, VAMP2, and/or VAMP3/cellubrevin are functional target membrane and vesicle SNAP receptors for insulin-stimulated GLUT4 translocation in adipocytes

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21 January 2018

The phosphatidylinositol 3-kinase inhibitor, wortmannin, inhibits insulin-induced activation of phosphatidylcholine hydrolysis and associated protein kinase C translocation in rat adipocytes

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21 January 2018

Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport

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21 January 2018

Compartment-specific regulation of phosphoinositide 3-kinase by platelet-derived growth factor and insulin in 3T3-L1 adipocytes

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21 January 2018

Insulin-mediated targeting of phosphatidylinositol 3-kinase to GLUT4-containing vesicles

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21 January 2018

Different effects of insulin and platelet-derived growth factor on phosphatidylinositol 3-kinase at the subcellular level in 3T3-L1 adipocytes. A possible explanation for their specific effects on glucose transport.

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21 January 2018

The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake

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21 January 2018

Epidermal growth factor (EGF) receptor carboxy-terminal domains are required for EGF-induced glucose transport in transgenic 3T3-L1 adipocytes

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21 January 2018

Platelet-derived growth factor triggers translocation of the insulin-regulatable glucose transporter (type 4) predominantly through phosphatidylinositol 3-kinase binding sites on the receptor

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21 January 2018

Overexpression of catalytic subunit p110alpha of phosphatidylinositol 3-kinase increases glucose transport activity with translocation of glucose transporters in 3T3-L1 adipocytes

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21 January 2018

Differential effects of constitutively active phosphatidylinositol 3-kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes

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21 January 2018

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

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21 January 2018

Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells

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A role for the serine/threonine kinase, Akt, in insulin-stimulated glucose uptake

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21 January 2018

Effects of insulin and phorbol esters on subcellular distribution of protein kinase C isoforms in rat adipocytes

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21 January 2018

Activation of protein kinase C (alpha, beta, and zeta) by insulin in 3T3/L1 cells. Transfection studies suggest a role for PKC-zeta in glucose transport

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21 January 2018

Protein kinase C isoforms epsilon, eta, delta and zeta in murine adipocytes: expression, subcellular localization and tissue-specific regulation in insulin-resistant states

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21 January 2018

A role for phospholipase C activity in GLUT4-mediated glucose transport

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21 January 2018

Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling

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Phospholipase D: a downstream effector of ARF in granulocytes

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Stimulation of phospholipase C activity by insulin is mediated by both isotypes of the human insulin receptor

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Evidence that protein kinase C is involved in regulating glucose transport in the adipocyte

1 reference

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7 January 2021

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Insulin increases mRNA levels of protein kinase C-alpha and -beta in rat adipocytes and protein kinase C-alpha, -beta and -theta in rat skeletal muscle

1 reference

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Evidence for involvement of phosphatidylcholine-phospholipase C and protein kinase C in transforming growth factor-beta signaling

1 reference

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Activation and translocation of Rho (and ADP ribosylation factor) by insulin in rat adipocytes. Apparent involvement of phosphatidylinositol 3-kinase

1 reference

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7 January 2021

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Protein kinase C and lipid signaling for sustained cellular responses

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Polarization-dependent apical membrane CFTR targeting underlies cAMP-stimulated Cl- secretion in epithelial cells

1 reference

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7 January 2021

based on heuristic

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The metabolic regulation and vesicular transport of GLUT4, the major insulin-responsive glucose transporter

1 reference

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7 January 2021

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Downregulation of protein kinase C and insulin-stimulated 2-deoxyglucose uptake in rat adipocytes by phorbol esters, glucose, and insulin

1 reference

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10.1074/JBC.273.22.13808

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