(Q24319910)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0061578

CYLD lysine 63 deubiquitinase

1 reference

negative regulation of NIK/NF-kappaB signaling

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

David Komander

1

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Alan Ashworth

6

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Christopher J Lord

object named as

Christopher J Lord

2

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author name string

Hartmut Scheel

3

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Sally Swift

4

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Kay Hofmann

5

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David Barford

TRIM/RBCC, a novel class of 'single protein RING finger' E3 ubiquitin ligases

7

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language of work or name

English

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publication date

29 February 2008

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published in

Molecular Cell

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volume

29

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issue

4

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page(s)

451-64

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cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

Protein structure comparison by alignment of distance matrices

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

Mechanism and function of deubiquitinating enzymes

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

The novel functions of ubiquitination in signaling

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

A genomic and functional inventory of deubiquitinating enzymes

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

CYLD in Ubiquitin Signaling and Tumor Pathogenesis

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

TRPA1 is a substrate for de-ubiquitination by the tumor suppressor CYLD

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

ZZ domain of CBP: an unusual zinc finger fold in a protein interaction module

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

Solution structure of the RBCC/TRIM B-box1 domain of human MID1: B-box with a RING.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

If the prophet does not come to the mountain: dynamics of signaling complexes in NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

Elemental analysis of proteins by microPIXE.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

The CAP-Gly domain of CYLD associates with the proline-rich sequence in NEMO/IKKgamma

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

Structural basis of ubiquitin recognition by the deubiquitinating protease USP2

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

A flexible motif search technique based on generalized profiles.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

Identification of the familial cylindromatosis tumour-suppressor gene

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

Temporal analysis of phosphotyrosine-dependent signaling networks by quantitative proteomics

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

Ubiquitin signalling in the NF-kappaB pathway

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

Familial cylindromatosis (turban tumour syndrome) gene localised to chromosome 16q12-q13: evidence for its role as a tumour suppressor gene

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

Regulation of T cell development by the deubiquitinating enzyme CYLD

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

Ubiquitin-mediated activation of TAK1 and IKK.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

The tumor suppressor CYLD regulates entry into mitosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

Solution structure of the Kaposi's sarcoma-associated herpesvirus K3 N-terminal domain reveals a Novel E2-binding C4HC3-type RING domain.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8)

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

Deubiquitinating enzyme CYLD regulates the peripheral development and naive phenotype maintenance of B cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

TopDraw: a sketchpad for protein structure topology cartoons

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

Reduced expression of CYLD in human colon and hepatocellular carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

ZZ domain is essentially required for the physiological binding of dystrophin and utrophin to beta-dystroglycan

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

ALSCRIPT: a tool to format multiple sequence alignments

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

PHENIX: building new software for automated crystallographic structure determination

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

Generation, representation and flow of phase information in structure determination: recent developments in and around SHARP 2.0

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

Coot: model-building tools for molecular graphics

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

Dermal eccrine cylindromatosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021

Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.12.018

7 January 2021