(Q24336146)

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Targeting of the small GTPase Rap2b, but not Rap1b, to lipid rafts is promoted by palmitoylation at Cys176 and Cys177 and is required for efficient protein activation in human platelets

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Targeting of the small GTPase Rap2b, but not Rap1b, to lipid rafts is promoted by palmitoylation at Cys176 and Cys177 and is required for efficient protein activation in human platelets (English)

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RAP1B, member of RAS oncogene family

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GOA release 2020-03-11

RAP2B, member of RAS oncogene family

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GOA release 2020-03-11

platelet aggregation

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GOA release 2020-03-11

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based on heuristic

inferred from title

author name string

Ilaria Canobbio

1

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Piera Trionfini

2

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Gianni F Guidetti

3

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Cesare Balduini

4

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Mauro Torti

5

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language of work or name

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publication date

September 2008

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Cellular Signalling

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20

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9

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1662-70

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Effects of the ras-related rap2 protein on cellular proliferation

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https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2008.05.016

7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence for a physiological role for membrane rafts in human platelets.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2008.05.016

7 January 2021

based on heuristic

inferred from DOI database lookup

The cAMP-dependent protein kinase phosphorylates the rap1 protein in vitro as well as in intact fibroblasts, but not the closely related rap2 protein

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2008.05.016

7 January 2021

based on heuristic

inferred from DOI database lookup

All ras proteins are polyisoprenylated but only some are palmitoylated

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2008.05.016

7 January 2021

based on heuristic

inferred from DOI database lookup

A ras-related gene with transformation suppressor activity

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https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2008.05.016

7 January 2021

based on heuristic

inferred from DOI database lookup

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2008.05.016

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification and biochemical characterization of Rap2C, a new member of the Rap family of small GTP-binding proteins

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2008.05.016

7 January 2021

based on heuristic

inferred from DOI database lookup

A new role for FcgammaRIIA in the potentiation of human platelet activation induced by weak stimulation

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2008.05.016

7 January 2021

based on heuristic

inferred from DOI database lookup

Lipid rafts are critical membrane domains in blood platelet activation processes

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2008.05.016

7 January 2021

based on heuristic

inferred from DOI database lookup

Ras and relatives--job sharing and networking keep an old family together

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2008.05.016

7 January 2021

based on heuristic

inferred from DOI database lookup

LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2008.05.016

7 January 2021

based on heuristic

inferred from DOI database lookup

Signaling through sphingolipid microdomains of the plasma membrane: the concept of signaling platform

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2008.05.016

7 January 2021

based on heuristic

inferred from DOI database lookup

The p21 ras C-terminus is required for transformation and membrane association

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2008.05.016

7 January 2021

based on heuristic

inferred from DOI database lookup

Ras proteins: different signals from different locations

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2008.05.016

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cgamma2 regulation in platelets

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2008.05.016

7 January 2021

based on heuristic

inferred from DOI database lookup

Lipid rafts: heterogeneity on the high seas

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2008.05.016

7 January 2021

based on heuristic

inferred from DOI database lookup

Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2008.05.016

7 January 2021

based on heuristic

inferred from DOI database lookup

Active Lyn protein tyrosine kinase is selectively enriched within membrane microdomains of resting platelets

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2008.05.016

7 January 2021

based on heuristic

inferred from DOI database lookup

The role of Rap1 in integrin-mediated cell adhesion

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2008.05.016

7 January 2021

based on heuristic

inferred from DOI database lookup

Posttranslationally processed structure of the human platelet protein smg p21B: evidence for geranylgeranylation and carboxyl methylation of the C-terminal cysteine

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2008.05.016

7 January 2021

based on heuristic

inferred from DOI database lookup

Cellular cholesterol efflux mediated by cyclodextrins

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2008.05.016

7 January 2021

based on heuristic

inferred from DOI database lookup

Lipid rafts orchestrate signaling by the platelet receptor glycoprotein VI.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2008.05.016

7 January 2021

based on heuristic

inferred from DOI database lookup

Relationships between Rap1b, affinity modulation of integrin alpha IIbbeta 3, and the actin cytoskeleton

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2008.05.016

7 January 2021

based on heuristic

inferred from DOI database lookup

The Rap GTPases regulate integrin-mediated adhesion, cell spreading, actin polymerization, and Pyk2 tyrosine phosphorylation in B lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2008.05.016

7 January 2021

based on heuristic

inferred from DOI database lookup

Localization of the adhesion receptor glycoprotein Ib-IX-V complex to lipid rafts is required for platelet adhesion and activation

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2008.05.016

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of the small GTPase Rap2B in agonist-stimulated human platelets

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2008.05.016

7 January 2021

based on heuristic

inferred from DOI database lookup

Rap2B-dependent stimulation of phospholipase C-epsilon by epidermal growth factor receptor mediated by c-Src phosphorylation of RasGRP3.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2008.05.016

7 January 2021

based on heuristic

inferred from DOI database lookup

Palmitoylation at Cys595 is essential for PECAM-1 localisation into membrane microdomains and for efficient PECAM-1-mediated cytoprotection.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2008.05.016

7 January 2021

based on heuristic

inferred from DOI database lookup

Rap1b is required for normal platelet function and hemostasis in mice

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2008.05.016

7 January 2021

based on heuristic

inferred from DOI database lookup

The small GTPase Rap1b regulates the cross talk between platelet integrin alpha2beta1 and integrin alphaIIbbeta3

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2008.05.016

7 January 2021

based on heuristic

inferred from DOI database lookup

Constitutive and functional association of the platelet collagen receptor glycoprotein VI-Fc receptor gamma-chain complex with membrane rafts

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2008.05.016

7 January 2021

based on heuristic

inferred from DOI database lookup

Model organisms lead the way to protein palmitoyltransferases

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2008.05.016

7 January 2021

based on heuristic

inferred from DOI database lookup

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10.1016/J.CELLSIG.2008.05.016

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