(Q24338132)

English

Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro

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scholarly article

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Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro (English)

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negative regulation of glucuronosyltransferase activity

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Gene Ontology release 2020-05-02

Gene Ontology ID

regulation of glucuronosyltransferase activity

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Gene Ontology release 2020-05-02

Gene Ontology ID

positive regulation of glucuronosyltransferase activity

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Gene Ontology release 2020-05-02

Gene Ontology ID

author name string

Judith Bellemare

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Mélanie Rouleau

2

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Hugo Girard

3

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Mario Harvey

4

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Chantal Guillemette

5

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language of work or name

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publication date

October 2010

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Drug Metabolism and Disposition

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38

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10

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1785-9

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Regulation of the UGT1A1 bilirubin-conjugating pathway: role of a new splicing event at the UGT1A locus

1 reference

https://api.crossref.org/works/10.1124%2FDMD.110.034835

7 January 2021

based on heuristic

inferred from DOI database lookup

Interactions between human UDP-glucuronosyltransferase (UGT) 2B7 and UGT1A enzymes.

1 reference

https://api.crossref.org/works/10.1124%2FDMD.110.034835

7 January 2021

based on heuristic

inferred from DOI database lookup

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://api.crossref.org/works/10.1124%2FDMD.110.034835

7 January 2021

based on heuristic

inferred from DOI database lookup

The interactions between the N-terminal and C-terminal domains of the human UDP-glucuronosyltransferases are partly isoform-specific, and may involve both monomers.

1 reference

https://api.crossref.org/works/10.1124%2FDMD.110.034835

7 January 2021

based on heuristic

inferred from DOI database lookup

Topological aspects of oligomeric UDP-glucuronosyltransferases in endoplasmic reticulum membranes: advances and open questions

1 reference

https://api.crossref.org/works/10.1124%2FDMD.110.034835

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein-protein interactions between UDP-glucuronosyltransferase isozymes in rat hepatic microsomes

1 reference

https://api.crossref.org/works/10.1124%2FDMD.110.034835

7 January 2021

based on heuristic

inferred from DOI database lookup

Alternative-splicing forms of the major phase II conjugating UGT1A gene negatively regulate glucuronidation in human carcinoma cell lines.

1 reference

https://api.crossref.org/works/10.1124%2FDMD.110.034835

7 January 2021

based on heuristic

inferred from DOI database lookup

UDP-glucuronosyltransferase, the role of the amino terminus in dimerization

1 reference

https://api.crossref.org/works/10.1124%2FDMD.110.034835

7 January 2021

based on heuristic

inferred from DOI database lookup

The Drosophila nitric-oxide synthase gene (dNOS) encodes a family of proteins that can modulate NOS activity by acting as dominant negative regulators.

1 reference

https://api.crossref.org/works/10.1124%2FDMD.110.034835

7 January 2021

based on heuristic

inferred from DOI database lookup

Homodimerization of human bilirubin-uridine-diphosphoglucuronate glucuronosyltransferase-1 (UGT1A1) and its functional implications

1 reference

https://api.crossref.org/works/10.1124%2FDMD.110.034835

7 January 2021

based on heuristic

inferred from DOI database lookup

Modulation of the human glucuronosyltransferase UGT1A pathway by splice isoform polypeptides is mediated through protein-protein interactions

1 reference

https://api.crossref.org/works/10.1124%2FDMD.110.034835

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression and characterization of recombinant human UDP-glucuronosyltransferases (UGTs). UGT1A9 is more resistant to detergent inhibition than other UGTs and was purified as an active dimeric enzyme.

1 reference

https://api.crossref.org/works/10.1124%2FDMD.110.034835

7 January 2021

based on heuristic

inferred from DOI database lookup

Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation

1 reference

https://api.crossref.org/works/10.1124%2FDMD.110.034835

7 January 2021

based on heuristic

inferred from DOI database lookup

Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus

1 reference

https://api.crossref.org/works/10.1124%2FDMD.110.034835

7 January 2021

based on heuristic

inferred from DOI database lookup

Interactions with other human UDP-glucuronosyltransferases attenuate the consequences of the Y485D mutation on the activity and substrate affinity of UGT1A6.

1 reference

https://api.crossref.org/works/10.1124%2FDMD.110.034835

7 January 2021

based on heuristic

inferred from DOI database lookup

Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity

1 reference

https://api.crossref.org/works/10.1124%2FDMD.110.034835

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of coexpression of UGT1A9 on enzymatic activities of human UGT1A isoforms.

1 reference

https://api.crossref.org/works/10.1124%2FDMD.110.034835

7 January 2021

based on heuristic

inferred from DOI database lookup

Stereoselective glucuronidation of 5-(4'-hydroxyphenyl)-5-phenylhydantoin by human UDP-glucuronosyltransferase (UGT) 1A1, UGT1A9, and UGT2B15: effects of UGT-UGT interactions.

1 reference

https://api.crossref.org/works/10.1124%2FDMD.110.034835

7 January 2021

based on heuristic

inferred from DOI database lookup

Interactions between human UGT1A1, UGT1A4, and UGT1A6 affect their enzymatic activities.

1 reference

https://api.crossref.org/works/10.1124%2FDMD.110.034835

7 January 2021

based on heuristic

inferred from DOI database lookup

The main role of UGT1A9 in the hepatic metabolism of mycophenolic acid and the effects of naturally occurring variants

1 reference

https://api.crossref.org/works/10.1124%2FDMD.110.034835

7 January 2021

based on heuristic

inferred from DOI database lookup

Simultaneous expression of guinea pig UDP-glucuronosyltransferase 2B21 and 2B22 in COS-7 cells enhances UDP-glucuronosyltransferase 2B21-catalyzed morphine-6-glucuronide formation.

1 reference

https://api.crossref.org/works/10.1124%2FDMD.110.034835

7 January 2021

based on heuristic

inferred from DOI database lookup

Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38).

1 reference

https://api.crossref.org/works/10.1124%2FDMD.110.034835

7 January 2021

based on heuristic

inferred from DOI database lookup

Human drug metabolism and the cytochromes P450: application and relevance of in vitro models

1 reference

https://api.crossref.org/works/10.1124%2FDMD.110.034835

7 January 2021

based on heuristic

inferred from DOI database lookup

Cloning, expression, and functional characterization of relaxin receptor (leucine-rich repeat-containing g protein-coupled receptor 7) splice variants from human fetal membranes

1 reference

https://api.crossref.org/works/10.1124%2FDMD.110.034835

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein-protein interactions between rat hepatic cytochromes P450 (P450s) and UDP-glucuronosyltransferases (UGTs): evidence for the functionally active UGT in P450-UGT complex

1 reference

https://api.crossref.org/works/10.1124%2FDMD.110.034835

7 January 2021

based on heuristic

inferred from DOI database lookup

The UDP-glucuronosyltransferases as oligomeric enzymes

1 reference

https://api.crossref.org/works/10.1124%2FDMD.110.034835

7 January 2021

based on heuristic

inferred from DOI database lookup

Modulation of UDP-glucuronosyltransferase activity by protein-protein association

1 reference

https://api.crossref.org/works/10.1124%2FDMD.110.034835

7 January 2021

based on heuristic

inferred from DOI database lookup

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10.1124/DMD.110.034835

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