(Q34430456)

2 August 2017

1 reference

title

Human drug metabolism and the cytochromes P450: application and relevance of in vitro models (English)

1 reference

2 August 2017

3

Greenblatt DJ

1 reference

2 August 2017

2

Von Moltke LL

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2 August 2017

Venkatakrishnan K

1

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2 August 2017

1 November 2001

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The Journal of Clinical Pharmacology

2 August 2017

1 reference

2 August 2017

41

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2 August 2017

1149-1179

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2 August 2017

11

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Forty years of cytochrome P450.

2 August 2017

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Nicotine metabolism defect reduces smoking.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Alternative splicing in the human cytochrome P450IIB6 gene generates a high level of aberrant messages

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Cytochrome P-450 2B6 is responsible for interindividual variability of propofol hydroxylation by human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Cytochrome P4502C9: an enzyme of major importance in human drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

In vitro inhibition studies of tolbutamide hydroxylase activity of human liver microsomes by azoles, sulphonamides and quinolines

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Effects of the antifungal agents on oxidative drug metabolism: clinical relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Site-directed mutation studies of human liver cytochrome P-450 isoenzymes in the CYP2C subfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Comparative studies on the catalytic roles of cytochrome P450 2C9 and its Cys- and Leu-variants in the oxidation of warfarin, flurbiprofen, and diclofenac by human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Catalytic activity of three variants (Ile, Leu, and Thr) at amino acid residue 359 in human CYP2C9 gene and simultaneous detection using single-strand conformation polymorphism analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Genetic polymorphism of the CYP2C subfamily and its effect on the pharmacokinetics of phenytoin in Japanese patients with epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Targeted antipeptide antibodies to cytochrome P450 2C18 based on epitope mapping of an inhibitory monoclonal antibody to P450 2C51

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Cloning and tissue distribution of a novel human cytochrome p450 of the CYP3A subfamily, CYP3A43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Cytochrome P-450 3A4: regulation and role in drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

In vitro and in vivo drug interactions involving human CYP3A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

In vitro assessment of human cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

In vitro approaches to predicting drug interactions in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Flavin-containing monooxygenase mediated metabolism of psychoactive drugs by human brain microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Flunitrazepam oxidative metabolism in human liver microsomes: involvement of CYP2C19 and CYP3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Regioselective and stereoselective metabolism of ibuprofen by human cytochrome P450 2C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Midazolam hydroxylation by human liver microsomes in vitro: inhibition by fluoxetine, norfluoxetine, and by azole antifungal agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

O- and N-demethylation of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: effect of metabolic inhibitors and SSRI antidepressants

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Cooperativity in oxidations catalyzed by cytochrome P450 3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Activation of CYP3A4: evidence for the simultaneous binding of two substrates in a cytochrome P450 active site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Analysis of human cytochrome P450 3A4 cooperativity: construction and characterization of a site-directed mutant that displays hyperbolic steroid hydroxylation kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Comparison of the Akaike Information Criterion, the Schwarz criterion and the F test as guides to model selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Enzyme kinetic modelling as a tool to analyse the behaviour of cytochrome P450 catalysed reactions: application to amitriptyline N-demethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Citalopram and desmethylcitalopram in vitro: human cytochromes mediating transformation, and cytochrome inhibitory effects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Zolpidem metabolism in vitro: responsible cytochromes, chemical inhibitors, and in vivo correlations

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Microsomal prediction of in vivo clearance of CYP2C9 substrates in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Nonspecific binding of drugs to human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Commentary: a physiological approach to hepatic drug clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Prediction of in vivo drug disposition from in vitro data based on physiological pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Activation of phenacetin O-deethylase activity by alpha-naphthoflavone in human liver microsomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Evaluation of triacetyloleandomycin, alpha-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Specificity of substrate and inhibitor probes for cytochrome P450s: evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Inhibition of CYP2C9 by selective serotonin reuptake inhibitors in vitro: studies of phenytoin p-hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Inhibition of CYP2C9 by selective serotonin reuptake inhibitors: in vitro studies with tolbutamide and (S)-warfarin using human liver microsomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Relative contributions of CYP2C9 and 2C19 to phenytoin 4-hydroxylation in vitro: inhibition by sulfaphenazole, omeprazole, and ticlopidine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Comparison of (S)-mephenytoin and proguanil oxidation in vitro: contribution of several CYP isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

The use of heterologously expressed drug metabolizing enzymes--state of the art and prospects for the future

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Drug metabolism by Escherichia coli expressing human cytochromes P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Reconstitution premixes for assays using purified recombinant human cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Human liver microsomal diazepam metabolism using cDNA-expressed cytochrome P450s: role of CYP2B6, 2C19 and the 3A subfamily.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Relative quantities of catalytically active CYP 2C9 and 2C19 in human liver microsomes: application of the relative activity factor approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Studies of flurbiprofen 4'-hydroxylation. Additional evidence suggesting the sole involvement of cytochrome P450 2C9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

The effect of the antimycotic itraconazole on the pharmacokinetics and pharmacodynamics of diazepam.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Extrapolating in vitro data on drug metabolism to in vivo pharmacokinetics: evaluation of the pharmacokinetic interaction between amitriptyline and fluoxetine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Inhibitors of alprazolam metabolism in vitro: effect of serotonin-reuptake-inhibitor antidepressants, ketoconazole and quinidine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

In vitro prediction of the terfenadine-ketoconazole pharmacokinetic interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

CYP3A4 drug interactions: correlation of 10 in vitro probe substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Inhibition of human cytochrome P450-3A isoforms by fluoxetine and norfluoxetine: in vitro and in vivo studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Cytochrome P450 enzymes: interpretation of their interactions with selective serotonin reuptake inhibitors. Part II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Effect of erythromycin and itraconazole on the pharmacokinetics of intravenous lignocaine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

The CYP 3A4 inhibitor itraconazole has no effect on the pharmacokinetics of i.v. fentanyl.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Differentiation of intestinal and hepatic cytochrome P450 3A activity with use of midazolam as an in vivo probe: effect of ketoconazole.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Extensive impairment of triazolam and alprazolam clearance by short-term low-dose ritonavir: the clinical dilemma of concurrent inhibition and induction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

In vitro metabolism of trazodone by CYP3A: inhibition by ketoconazole and human immunodeficiency viral protease inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Potential interaction between ritonavir and carbamazepine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

The effect of ritonavir on the pharmacokinetics of meperidine and normeperidine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Induction of P-glycoprotein expression by HIV protease inhibitors in cell culture.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Drug-mediated inactivation of cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Inhibition of human cytochrome P450 isoforms by nonnucleoside reverse transcriptase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

Relationship between CYP2C9 and 2C19 genotypes and tolbutamide methyl hydroxylation and S-mephenytoin 4'-hydroxylation activities in livers of Japanese and Caucasian populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F00912700122012724

10.1177/00912700122012724

21 January 2018

Identifiers

DOI

1 reference

2 August 2017

1 reference

PubMed ID

11697750