(Q24338346)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24576675%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

title

LRRK2, but not pathogenic mutants, protects against H2O2 stress depending on mitochondrial function and endocytosis in a yeast model (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24576675%20AND%20SRC:MED&resulttype=core&format=json

Leucine rich repeat kinase 2

9 March 2020

main subject

endocytosis

0 references

1 reference

negative regulation of hydrogen peroxide-induced cell death

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Clara Pereira

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24576675%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

Lucília Saraiva

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24576675%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

author name string

L Miguel Martins

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24576675%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

language of work or name

English

0 references

publication date

24 February 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24576675%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

number of pages

7

1 reference

Biochimica et Biophysica Acta

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24576675%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

volume

1840

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24576675%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24576675%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

page(s)

2025-2031

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24576675%20AND%20SRC:MED&resulttype=core&format=json

Localization of LRRK2 to membranous and vesicular structures in mammalian brain

9 March 2020

cites work

1 reference

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Prevention of intracellular degradation of I2020T mutant LRRK2 restores its protectivity against apoptosis

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The absence of a mitochondrial genome in rho0 yeast cells extends lifespan independently of retrograde regulation

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Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

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Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway

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The familial Parkinsonism gene LRRK2 regulates neurite process morphology

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LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis

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7 January 2021

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LRRK2 regulates synaptic vesicle endocytosis

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7 January 2021

LRRK2 enhances oxidative stress-induced neurotoxicity via its kinase activity

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7 January 2021

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

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7 January 2021

Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

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7 January 2021

A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling

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7 January 2021

High-efficiency yeast transformation using the LiAc/SS carrier DNA/PEG method

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7 January 2021

Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker's yeast?

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7 January 2021

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

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7 January 2021

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

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7 January 2021

A new vital stain for visualizing vacuolar membrane dynamics and endocytosis in yeast

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7 January 2021

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

1 reference

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7 January 2021

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

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7 January 2021

LRRK2 Parkinson disease mutations enhance its microtubule association.

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7 January 2021

Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning

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7 January 2021

LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1

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7 January 2021

G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization

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7 January 2021

LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6

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7 January 2021

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7 January 2021

MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2

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7 January 2021

Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein

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7 January 2021

Endocytosis inhibition during H2O2-induced apoptosis in yeast

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7 January 2021

Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons

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7 January 2021

Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2.

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7 January 2021

Specific modulation of apoptosis and Bcl-xL phosphorylation in yeast by distinct mammalian protein kinase C isoforms

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7 January 2021

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7 January 2021

Deletion of the WD40 domain of LRRK2 in Zebrafish causes Parkinsonism-like loss of neurons and locomotive defect

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7 January 2021

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7 January 2021

LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans

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7 January 2021

Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.

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7 January 2021

LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool

1 reference

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7 January 2021

New therapeutic strategies for cancer and neurodegeneration emerging from yeast cell-based systems.

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7 January 2021

GST P1, a novel downstream regulator of LRRK2, G2019S-induced neuronal cell death

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7 January 2021

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1 reference

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7 January 2021

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Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24576675%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1 reference