(Q37996364)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22441981%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

title

Mechanisms of LRRK2-mediated neurodegeneration (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22441981%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

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1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22441981%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

2

Darren J Moore

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22441981%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

publication date

1 June 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22441981%20AND%20SRC:MED&resulttype=core&format=json

Current Neurology and Neuroscience Reports

26 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22441981%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

volume

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22441981%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22441981%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

page(s)

251-260

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22441981%20AND%20SRC:MED&resulttype=core&format=json

Mendelian forms of Parkinson's disease

26 January 2020

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Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

21 January 2018

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

21 January 2018

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Genome-wide association study reveals genetic risk underlying Parkinson's disease

21 January 2018

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Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

21 January 2018

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Zeroing in on LRRK2-linked pathogenic mechanisms in Parkinson's disease.

21 January 2018

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Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

21 January 2018

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Biochemical and pathological characterization of Lrrk2.

21 January 2018

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Lrrk2 and Lewy body disease

21 January 2018

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Autosomal dominant parkinsonism associated with variable synuclein and tau pathology

21 January 2018

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LRRK2 in Parkinson's disease: protein domains and functional insights

21 January 2018

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Membrane localization of LRRK2 is associated with increased formation of the highly active LRRK2 dimer and changes in its phosphorylation

21 January 2018

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The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

21 January 2018

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Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

21 January 2018

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Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization

21 January 2018

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The WD40 domain is required for LRRK2 neurotoxicity

21 January 2018

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Dynamic and redundant regulation of LRRK2 and LRRK1 expression

21 January 2018

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Localization of LRRK2 to membranous and vesicular structures in mammalian brain

21 January 2018

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LRRK2 expression linked to dopamine-innervated areas

21 January 2018

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Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain

21 January 2018

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Expression and localization of Parkinson's disease-associated leucine-rich repeat kinase 2 in the mouse brain

21 January 2018

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Developmental regulation of leucine-rich repeat kinase 1 and 2 expression in the brain and other rodent and human organs: Implications for Parkinson's disease.

21 January 2018

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LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Anatomical localization of leucine-rich repeat kinase 2 in mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Leucine-rich repeat kinase 2 associates with lipid rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Leucine-rich repeat kinase 2 induces alpha-synuclein expression via the extracellular signal-regulated kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability--a point of convergence in parkinsonian neurodegeneration?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications

21 January 2018

1 reference

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LRRK2 G2019S mutation induces dendrite degeneration through mislocalization and phosphorylation of tau by recruiting autoactivated GSK3ß.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Phosphopeptide analysis reveals two discrete clusters of phosphorylation in the N-terminus and the Roc domain of the Parkinson-disease associated protein kinase LRRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Identification of the autophosphorylation sites of LRRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

The R1441C mutation of LRRK2 disrupts GTP hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Kinase activity of mutant LRRK2 mediates neuronal toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Sequestration of highly expressed mRNAs in cytoplasmic granules, P-bodies, and stress granules enhances cell viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

GTPase activity plays a key role in the pathobiology of LRRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

A Drosophila model for LRRK2-linked parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

A rat model of progressive nigral neurodegeneration induced by the Parkinson's disease-associated G2019S mutation in LRRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

LRRK2 regulates synaptic vesicle endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Apoptotic mechanisms in mutant LRRK2-mediated cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

The familial Parkinsonism gene LRRK2 regulates neurite process morphology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Microtubule assembly, organization and dynamics in axons and dendrites

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

LRRK2 Parkinson disease mutations enhance its microtubule association.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Parkinsonism, Lrrk2 G2019S, and tau neuropathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

The Parkinson's disease protein LRRK2 impairs proteasome substrate clearance without affecting proteasome catalytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0265-8

Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S

21 January 2018

1 reference

12 December 2020

Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions

1 reference

12 December 2020

GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1

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12 December 2020

Parkinson's disease. Second of two parts

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12 December 2020

Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning

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12 December 2020

The biology and pathobiology of LRRK2: implications for Parkinson's disease

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12 December 2020

LRK-1, a C. elegans PARK8-related kinase, regulates axonal-dendritic polarity of SV proteins

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12 December 2020

Parkinson's disease. First of two parts

1 reference

12 December 2020

Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants

1 reference

12 December 2020

LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1

1 reference

12 December 2020

10.1007/S11910-012-0265-8

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22441981%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

1 reference