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Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities
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Europe PubMed Central
PMC publication ID
3158845
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21806997%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
title
Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
3158845
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21806997%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
author
Matthew B. Renfrow
series ordinal
4
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Europe PubMed Central
PMC publication ID
3158845
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21806997%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
Andrew B. West
series ordinal
6
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Europe PubMed Central
PMC publication ID
3158845
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21806997%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
author name string
Philip J Webber
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1
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PMC publication ID
3158845
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21806997%20AND%20SRC:MED&resulttype=core&format=json
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9 February 2020
Archer D Smith
series ordinal
2
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PMC publication ID
3158845
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21806997%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
Saurabh Sen
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
3158845
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21806997%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
James A Mobley
series ordinal
5
1 reference
stated in
Europe PubMed Central
PMC publication ID
3158845
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21806997%20AND%20SRC:MED&resulttype=core&format=json
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9 February 2020
language of work or name
English
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publication date
22 July 2011
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stated in
Europe PubMed Central
PMC publication ID
3158845
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21806997%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
published in
Journal of Molecular Biology
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stated in
Europe PubMed Central
PMC publication ID
3158845
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21806997%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
volume
412
1 reference
stated in
Europe PubMed Central
PMC publication ID
3158845
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21806997%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
issue
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
3158845
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21806997%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
page(s)
94-110
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stated in
Europe PubMed Central
PMC publication ID
3158845
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21806997%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
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Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis
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The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites
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Leucine-rich repeat kinase 2 expression leads to aggresome formation that is not associated with alpha-synuclein inclusions
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The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro
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Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway
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LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity
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GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease
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Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity
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Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
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The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mechanism
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Protein kinase FA/glycogen synthase kinase-3 predominantly phosphorylates the in vivo site Thr97-Pro in brain myelin basic protein: evidence for Thr-Pro and Ser-Arg-X-X-Ser as consensus sequence motifs
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Phosphopeptide analysis reveals two discrete clusters of phosphorylation in the N-terminus and the Roc domain of the Parkinson-disease associated protein kinase LRRK2.
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MAPK-pathway activity, Lrrk2 G2019S, and Parkinson's disease
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Protected-site phosphorylation of protein kinase C in hippocampal long-term potentiation
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Mechanistic insight into the dominant mode of the Parkinson's disease-associated G2019S LRRK2 mutation
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Identification of multiple in vivo phosphorylation sites in rabbit myelin basic protein
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retrieved
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based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.JMB.2011.07.033
1 reference
stated in
Europe PubMed Central
PMC publication ID
3158845
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21806997%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
PMC publication ID
3158845
1 reference
stated in
Europe PubMed Central
PMC publication ID
3158845
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21806997%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
PubMed publication ID
21806997
1 reference
stated in
Europe PubMed Central
PMC publication ID
3158845
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21806997%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 February 2020
ResearchGate publication ID
51538217
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