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The R1441C mutation alters the folding properties of the ROC domain of LRRK2.
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1 reference
stated in
Europe PubMed Central
PMC publication ID
2846748
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19781641%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
title
The R1441C mutation alters the folding properties of the ROC domain of LRRK2
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
2846748
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19781641%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
author
Graham S Jackson
series ordinal
5
1 reference
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Europe PubMed Central
PMC publication ID
2846748
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19781641%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
Patrick A. Lewis
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7
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Europe PubMed Central
PMC publication ID
2846748
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19781641%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
author name string
Yongchao Li
series ordinal
1
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Europe PubMed Central
PMC publication ID
2846748
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19781641%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
Laura Dunn
series ordinal
2
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Europe PubMed Central
PMC publication ID
2846748
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19781641%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
Elisa Greggio
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
2846748
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19781641%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
Brian Krumm
series ordinal
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
2846748
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19781641%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
Junpeng Deng
series ordinal
8
1 reference
stated in
Europe PubMed Central
PMC publication ID
2846748
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19781641%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
Mark R Cookson
series ordinal
6
1 reference
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Europe PubMed Central
PMC publication ID
2846748
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19781641%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
language of work or name
English
0 references
publication date
23 September 2009
1 reference
stated in
Europe PubMed Central
PMC publication ID
2846748
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19781641%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
published in
Biochimica et Biophysica Acta
1 reference
stated in
Europe PubMed Central
PMC publication ID
2846748
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19781641%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
volume
1792
1 reference
stated in
Europe PubMed Central
PMC publication ID
2846748
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19781641%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
issue
12
1 reference
stated in
Europe PubMed Central
PMC publication ID
2846748
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19781641%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
page(s)
1194-1197
1 reference
stated in
Europe PubMed Central
PMC publication ID
2846748
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19781641%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
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PubMed Central
reference URL
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Structure of the Roc–COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase
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14 July 2018
The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation
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PubMed Central
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14 July 2018
Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase
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14 July 2018
The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity
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reference URL
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14 July 2018
Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants
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LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity
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14 July 2018
The R1441C mutation of LRRK2 disrupts GTP hydrolysis
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PubMed Central
reference URL
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14 July 2018
GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease
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PubMed Central
reference URL
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14 July 2018
Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity
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PubMed Central
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14 July 2018
Kinase activity of mutant LRRK2 mediates neuronal toxicity
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14 July 2018
Kinase activity is required for the toxic effects of mutant LRRK2/dardarin
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14 July 2018
The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity
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14 July 2018
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
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14 July 2018
LRRK1 protein kinase activity is stimulated upon binding of GTP to its Roc domain
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846748
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14 July 2018
Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology
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Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
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Roc, a Ras/GTPase domain in complex proteins
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14 July 2018
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ROCO kinase activity is controlled by internal GTPase function
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Ligand binding is the principal determinant of stability for the p21(H)-ras protein.
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The Parkinson disease gene LRRK2: evolutionary and structural insights
1 reference
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PubMed
reference URL
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retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.BBADIS.2009.09.010
1 reference
stated in
Europe PubMed Central
PMC publication ID
2846748
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19781641%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
PMC publication ID
2846748
1 reference
stated in
Europe PubMed Central
PMC publication ID
2846748
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19781641%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
PubMed publication ID
19781641
1 reference
stated in
Europe PubMed Central
PMC publication ID
2846748
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19781641%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
ResearchGate publication ID
26838489
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