(Q47718405)

5 February 2018

title

LRRK2 gene variation and its contribution to Parkinson disease. (English)

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5 February 2018

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1

Coro Paisán-Ruiz

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publication date

1 August 2009

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5 February 2018

published in

Human Mutation

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5 February 2018

volume

30

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5 February 2018

issue

8

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5 February 2018

page(s)

1153-1160

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5 February 2018

A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease

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7 January 2021

LRRK2 Gly2385Arg variant is a risk factor of Parkinson's disease among Han-Chinese from mainland China

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7 January 2021

Type and frequency of mutations in the LRRK2 gene in familial and sporadic Parkinson's disease*.

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7 January 2021

Common variants of LRRK2 are not associated with sporadic Parkinson's disease

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7 January 2021

Localization of LRRK2 to membranous and vesicular structures in mammalian brain

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7 January 2021

G2019S dardarin substitution is a common cause of Parkinson's disease in a Portuguese cohort

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7 January 2021

Leucine-rich repeat kinase 2 (LRRK2) mutations in a Swedish Parkinson cohort and a healthy nonagenarian

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7 January 2021

Tremor dominant parkinsonism: Clinical description and LRRK2 mutation screening.

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7 January 2021

Clinical and pathological characteristics of patients with leucine-rich repeat kinase-2 mutations

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7 January 2021

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

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https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Comprehensive analysis of the LRRK2 gene in sixty families with Parkinson's disease

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https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

A common missense variant in the LRRK2 gene, Gly2385Arg, associated with Parkinson's disease risk in Taiwan

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7 January 2021

Clinical characteristics of Parkinson's disease among Jewish Ethnic groups in Israel

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7 January 2021

Lrrk2 G2385R is an ancestral risk factor for Parkinson's disease in Asia

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https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

High prevalence of LRRK2 mutations in familial and sporadic Parkinson's disease in Portugal

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7 January 2021

Genetic analysis for five LRRK2 mutations in a Sardinian parkinsonian population: importance of G2019S and R1441C mutations in sporadic Parkinson's disease patients.

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7 January 2021

An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family.

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https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

A common genetic factor for Parkinson disease in ethnic Chinese population in Taiwan

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https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

LRRK2 mutations in Spanish patients with Parkinson disease: frequency, clinical features, and incomplete penetrance

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https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

G2019S LRRK2 mutation causing Parkinson's disease without Lewy bodies

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https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

LRRK2 expression linked to dopamine-innervated areas

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https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Biochemical and pathological characterization of Lrrk2.

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7 January 2021

The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

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7 January 2021

The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson's disease and originates from a common ancestor

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https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Lrrk2-associated parkinsonism is a major cause of disease in Northern Spain

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7 January 2021

LRRK2 G2019S and R1441G mutations associated with Parkinson's disease are common in the Basque Country, but relative prevalence is determined by ethnicity.

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https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

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https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Reporting and interpretation of genetic variants in cases and controls

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Leucine-rich repeat kinase 2 associates with lipid rafts

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

A novelLRRK2 mutation in an Austrian cohort of patients with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson disease.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

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https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Clinical and positron emission tomography of Parkinson's disease caused by LRRK2.

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https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Prevalence and clinical features of common LRRK2 mutations in Australians with Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Clinical features of Parkinson disease patients with homozygous leucine-rich repeat kinase 2 G2019S mutations.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Comprehensive screening of a North American Parkinson's disease cohort for LRRK2 mutation.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Escaping Parkinson's disease: a neurologically healthy octogenarian with the LRRK2 G2019S mutation

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

G2019S LRRK2 mutation in French and North African families with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

LRRK2G2019S as a Cause of Parkinson's Disease in North African Arabs

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https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

LRRK2 exon 41 mutations in sporadic Parkinson disease in Europeans

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https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Is the common LRRK2 G2019S mutation related to dyskinesias in North African Parkinson disease?

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

The R1441C mutation of LRRK2 disrupts GTP hydrolysis

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

The LRRK2 Arg1628Pro variant is a risk factor for Parkinson's disease in the Chinese population

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

The Roco protein family: a functional perspective

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Frequency and phenotypes of LRRK2 G2019S mutation in Italian patients with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

LRRK2 R1441G in Spanish patients with Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

LRRK2 mutation analysis in Parkinson disease families with evidence of linkage to PARK8.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Founder mutation p.R1441C in the leucine-rich repeat kinase 2 gene in Belgian Parkinson's disease patients

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

LRRK2 gene in Parkinson disease: Mutation analysis and case control association study

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Familial Parkinson's disease: clinical and genetic analysis of four Basque families.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Testing association between LRRK2 and Parkinson's disease and investigating linkage disequilibrium

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Comprehensive analysis of LRRK2 in publicly available Parkinson's disease cases and neurologically normal controls

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Clinical Heterogeneity of the LRRK2 G2019S Mutation

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Screening for LRRK2 mutations in patients with Parkinson's disease in Russia: identification of a novel LRRK2 variant

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Mapping of a gene for Parkinson's disease to chromosome 4q21-q23

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Lrrk2 and Lewy body disease

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

LRRK2 and neurodegeneration

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

The LRRK2 gene in Parkinson's disease: mutation screening in patients from Germany

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Parkinson's disease due to the R1441G mutation in Dardarin: a founder effect in the Basques

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

alpha-Synuclein locus triplication causes Parkinson's disease

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Comprehensive evaluation of common genetic variation within LRRK2 reveals evidence for association with sporadic Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Analysis of LRRK2 functional domains in nondominant Parkinson disease.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Kinase activity of mutant LRRK2 mediates neuronal toxicity

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

The LRRK2 Gly2385Arg variant is associated with Parkinson's disease: genetic and functional evidence.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Essential tremor and the common LRRK2 G2385R variant

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Pathogenicity of LRRK2 P755L variant in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

LRRK2 R1628P increases risk of Parkinson's disease: replication evidence

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Lrrk2 R1628P in non-Chinese Asian races

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Clinicogenetic study of mutations inLRRK2 exon 41 in Parkinson's disease patients from 18 countries

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

LRRK2 P755L variant in sporadic Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

A founding LRRK2 haplotype shared by Tunisian, US, European and Middle Eastern families with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Prevalence of the LRRK2 G2019S mutation in a UK community based idiopathic Parkinson's disease cohort.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Screening for SNCA and LRRK2 mutations in Greek sporadic and autosomal dominant Parkinson's disease: identification of two novel LRRK2 variants

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

A clinic-based study of the LRRK2 gene in Parkinson disease yields new mutations

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

LRRK2 G2019S in families with Parkinson disease who originated from Europe and the Middle East: evidence of two distinct founding events beginning two millennia ago.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Identification and haplotype analysis of LRRK2 G2019S in Japanese patients with Parkinson disease

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21038

7 January 2021

Identifiers

DOI

10.1002/HUMU.21038

1 reference

5 February 2018

PubMed ID

19472409

1 reference

5 February 2018