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Distinct roles of PTCH2 splice variants in Hedgehog signalling
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scholarly article
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stated in
Europe PubMed Central
PMC publication ID
1223965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14613484%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 December 2019
title
Distinct roles of PTCH2 splice variants in Hedgehog signalling
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
1223965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14613484%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 December 2019
main subject
cell biology
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author
Peter G Zaphiropoulos
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
1223965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14613484%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 December 2019
author name string
Fahimeh Rahnama
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
1223965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14613484%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 December 2019
Rune Toftgård
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
1223965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14613484%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 December 2019
language of work or name
English
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publication date
1 March 2004
1 reference
stated in
Europe PubMed Central
PMC publication ID
1223965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14613484%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 December 2019
published in
Biochemical Journal
1 reference
stated in
Europe PubMed Central
PMC publication ID
1223965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14613484%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 December 2019
volume
378
1 reference
stated in
Europe PubMed Central
PMC publication ID
1223965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14613484%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 December 2019
issue
Pt 2
1 reference
stated in
Europe PubMed Central
PMC publication ID
1223965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14613484%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 December 2019
page(s)
325-334
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Europe PubMed Central
PMC publication ID
1223965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14613484%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 December 2019
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The sonic hedgehog receptor patched associates with caveolin-1 in cholesterol-rich microdomains of the plasma membrane
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Patched acts catalytically to suppress the activity of Smoothened
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Sonic hedgehog induces the segregation of patched and smoothened in endosomes
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Gli1 can rescue the in vivo function of Gli2
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GLI1 localization in the germinal epithelial cells alternates between cytoplasm and nucleus: upregulation in transgenic mice blocks spermatogenesis in pachytene
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Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation
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Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
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Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation
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Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein
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24 March 2017
PTCH2, a novel human patched gene, undergoing alternative splicing and up-regulated in basal cell carcinomas
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PubMed Central
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24 March 2017
Identification of a palmitic acid-modified form of human Sonic hedgehog
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24 March 2017
Cholesterol modification of hedgehog signaling proteins in animal development
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Human homolog of patched, a candidate gene for the basal cell nevus syndrome
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Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened
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24 March 2017
Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells
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24 March 2017
Sonic hedgehog signaling is essential for hair development
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24 March 2017
Altered neural cell fates and medulloblastoma in mouse patched mutants
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Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1
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Alternative splicing: increasing diversity in the proteomic world
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Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog
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7 April 2017
Alternative first exons of PTCH1 are differentially regulated in vivo and may confer different functions to the PTCH1 protein
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Several PATCHED1 missense mutations display activity in patched1-deficient fibroblasts
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27 September 2017
In vivo functions of the patched protein: requirement of the C terminus for target gene inactivation but not Hedgehog sequestration
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27 September 2017
Isolation and characterization of human patched 2 (PTCH2), a putative tumour suppressor gene inbasal cell carcinoma and medulloblastoma on chromosome 1p32.
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27 September 2017
Sertoli cell signaling by Desert hedgehog regulates the male germline
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223965
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27 September 2017
Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion
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30 May 2018
Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome
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30 May 2018
Related membrane domains in proteins of sterol sensing and cell signaling provide a glimpse of treasures still buried within the dynamic realm of intracellular metabolic regulation
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30 May 2018
Molecular cytogenetic analysis of adult testicular germ cell tumours and identification of regions of consensus copy number change
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30 May 2018
Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223965
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30 May 2018
Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb
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PubMed Central
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30 May 2018
Distinct consequences of sterol sensor mutations in Drosophila and mouse patched homologs
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29 November 2018
Ptc1 and Ptc2 transcripts provide distinct readouts of Hedgehog signaling activity during chick embryogenesis.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223965
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29 November 2018
The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223965
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29 November 2018
Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223965
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29 November 2018
The Shh signalling pathway in early tooth development.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223965
retrieved
29 November 2018
Gli family members are differentially expressed during the mitotic phase of spermatogenesis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223965
retrieved
29 November 2018
Suppression of hair follicle development inhibits induction of sonic hedgehog, patched, and patched-2 in hair germs in mice
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/14613484
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/14613484
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1042/BJ20031200
1 reference
stated in
Europe PubMed Central
PMC publication ID
1223965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14613484%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 December 2019
Fatcat ID
release_ampohsmpzzdq3l4gmmc63vvhza
0 references
PMC publication ID
1223965
1 reference
stated in
Europe PubMed Central
PMC publication ID
1223965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14613484%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 December 2019
PubMed publication ID
14613484
1 reference
stated in
Europe PubMed Central
PMC publication ID
1223965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14613484%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 December 2019
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