(Q24548765)

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Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease

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Europe PubMed Central

Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease (English)

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Behçet's disease

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author name string

Noboru Suzuki

1

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Kazuhiko Nara

2

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Tomoko Suzuki

3

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language of work or name

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publication date

June 2006

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Clinical Medicine and Research

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4

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2

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147-51

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Evidence of autophosphorylation in Txk: Y91 is an autophosphorylation site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483892

24 March 2017

Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483892

24 March 2017

Txk, a nonreceptor tyrosine kinase of the Tec family, is expressed in T helper type 1 cells and regulates interferon gamma production in human T lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483892

24 March 2017

TEC-family kinases: regulators of T-helper-cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483892

27 September 2017

Tec family kinases in T lymphocyte development and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483892

27 September 2017

Bruton's tyrosine kinase: cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483892

27 September 2017

Behcet's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483892

27 September 2017

Tc1/Tc2 ratio in the inflammatory process in patients with Behçet's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483892

27 September 2017

A phosphorylation site in Bruton's tyrosine kinase selectively regulates B cell calcium signaling efficiency by altering phospholipase C-gamma activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483892

27 September 2017

The role of heat shock proteins in Behçet's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483892

27 September 2017

Behçet syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483892

27 September 2017

T-bet expression is upregulated in active Behcet's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483892

27 September 2017

Pathogenesis of Adamantiades-Behçet's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483892

27 September 2017

Molecular mechanisms regulating Th1 immune responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483892

27 September 2017

Behçet's disease: infectious aetiology, new autoantigens, and HLA-B51

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483892

27 September 2017

T cell chemokine receptor expression in human Th1- and Th2-associated diseases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483892

27 September 2017

Follicular homing T helper (Th) cells and the Th1/Th2 paradigm

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483892

27 September 2017

Signaling and transcription in T helper development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483892

27 September 2017

T cell responses to 60/65 kDa heat shock protein derived peptides in Turkish patients with Behçet's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483892

27 September 2017

Behçet's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483892

27 September 2017

Macrophages induce cellular immunity by activating Th1 cell responses and suppressing Th2 cell responses.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483892

27 September 2017

Overproduction of monocyte derived tumor necrosis factor alpha, interleukin (IL) 6, IL-8 and increased neutrophil superoxide generation in Behçet's disease. A comparative study with familial Mediterranean fever and healthy subjects.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483892

27 September 2017

Molecular mechanisms in Behcet's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483892

30 May 2018

The role of heat shock protein, microbial and autoimmune agents in the aetiology of Behçet's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483892

30 May 2018

T cell epitope expression of mycobacterial and homologous human 65-kilodalton heat shock protein peptides in short term cell lines from patients with Behçet's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483892

30 May 2018

Immunohistology of skin pathergy reaction in Behçet's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483892

30 May 2018

Involvement of Th1 cells and heat shock protein 60 in the pathogenesis of intestinal Behcet's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483892

28 November 2018

Excessive expression of Txk, a member of the Tec family of tyrosine kinases, contributes to excessive Th1 cytokine production by T lymphocytes in patients with Behcet's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483892

28 November 2018

Clinical and immunological effects of azithromycin in Behçet's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483892

28 November 2018

Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483892

28 November 2018

Th1-dominant shift of T cell cytokine production, and subsequent reduction of serum immunoglobulin E response by administration in vivo of plasmid expressing Txk/Rlk, a member of Tec family tyrosine kinases, in a mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483892

28 November 2018

IL-18 mRNA expression and IFN-gamma induction in bronchoalveolar lavage from Behçet's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483892

28 November 2018

Characterization of T cells specific for an epitope of human 60-kD heat shock protein (hsp) in patients with Behcet's disease (BD) in Japan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483892

28 November 2018

Detection of RNA complementary to herpes-simplex virus in mononuclear cells from patients with Behçet's syndrome and recurrent oral ulcers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1483892

28 November 2018

Increased frequencies of interleukin-2- and interferon-gamma-producing T cells in patients with active Behçet's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16809408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Th1 polarization of the immune response in Behçet's disease: a putative pathogenetic role of interleukin-12

1 reference

https://pubmed.ncbi.nlm.nih.gov/16809408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systemic levels of the T cell regulatory cytokines IL-10 and IL-12 in Bechçet's disease; soluble TNFR-75 as a biological marker of disease activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16809408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Divergent cytokine production profile in Behçet's disease. Altered Th1/Th2 cell cytokine pattern

1 reference

https://pubmed.ncbi.nlm.nih.gov/16809408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo mechanisms for the inhibition of T lymphocyte activation by long-term therapy with tacrolimus (FK-506): experience in patients with Behçet's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16809408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokine profile in Behçet's disease patients. Relationship with disease activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16809408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behçet's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16809408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal killer inhibitory receptor expression on natural killer cells in patients with Behçet's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16809408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant Fas ligand expression in lymphocytes in patients with Behçet's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16809408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behçet's disease: an update on the pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16809408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunopathogenesis of Behçet's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16809408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal expression of chemokine receptors in Behçet's disease: relationship to intracellular Th1/Th2 cytokines and to clinical manifestations

1 reference

https://pubmed.ncbi.nlm.nih.gov/16809408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Natural killer cell activity, interferon-gamma and antibodies to herpes viruses in patients with Behçet's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16809408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokines and chemokines in neuro-Behçet's disease compared to multiple sclerosis and other neurological diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/16809408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.3121/CMR.4.2.147

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