(Q36085610)

12 August 2017

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title

TEC-family kinases: regulators of T-helper-cell differentiation (English)

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12 August 2017

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Pamela L Schwartzberg

series ordinal

1

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12 August 2017

Lisa D Finkelstein

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2

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12 August 2017

Julie A Readinger

series ordinal

3

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12 August 2017

publication date

1 April 2005

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Nature Reviews Immunology

12 August 2017

published in

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12 August 2017

volume

5

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12 August 2017

issue

4

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12 August 2017

page(s)

284-295

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Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia

12 August 2017

cites work

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The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases

21 January 2018

1 reference

Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice

21 January 2018

1 reference

Mutation analysis of the Bruton's tyrosine kinase gene in X-linked agammaglobulinemia: identification of a mutation which affects the same codon as is altered in immunodeficient xid mice

21 January 2018

1 reference

The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species

21 January 2018

1 reference

Tec family kinases in T lymphocyte development and function

21 January 2018

1 reference

Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk.

21 January 2018

1 reference

T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells

21 January 2018

1 reference

Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity

21 January 2018

1 reference

Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells

21 January 2018

1 reference

Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP.

21 January 2018

1 reference

Inducible T cell tyrosine kinase regulates actin-dependent cytoskeletal events induced by the T cell antigen receptor

21 January 2018

1 reference

A novel function for the Tec family tyrosine kinase Itk in activation of beta 1 integrins by the T-cell receptor

21 January 2018

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Defective Fas ligand expression and activation-induced cell death in the absence of IL-2-inducible T cell kinase

21 January 2018

1 reference

Attenuation of Immunological Symptoms of Allergic Asthma in Mice Lacking the Tyrosine Kinase ITK

21 January 2018

1 reference

Identification of Highly Expressed Genes in Peripheral Blood T Cells from Patients with Atopic Dermatitis

21 January 2018

1 reference

Selective Itk inhibitors block T-cell activation and murine lung inflammation

21 January 2018

1 reference

PtdIns-3,4,5-P3: a regulatory nexus between tyrosine kinases and sustained calcium signals

21 January 2018

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SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase

21 January 2018

1 reference

Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation

21 January 2018

1 reference

Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinase

21 January 2018

1 reference

rlk/TXK encodes two forms of a novel cysteine string tyrosine kinase activated by Src family kinases

21 January 2018

1 reference

Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk

21 January 2018

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Regulatory intramolecular association in a tyrosine kinase of the Tec family

21 January 2018

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Regulation of the tyrosine kinase Itk by the peptidyl-prolyl isomerase cyclophilin A

21 January 2018

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The role of Tec family kinases in T cell development and function

21 January 2018

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Cyclophilin A regulates TCR signal strength in CD4+ T cells via a proline-directed conformational switch in Itk.

21 January 2018

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Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet

21 January 2018

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Expression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for Tec

21 January 2018

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Signal transduction by the TCR for antigen

21 January 2018

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Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins

21 January 2018

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Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade

21 January 2018

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Interaction of SLP adaptors with the SH2 domain of Tec family kinases

21 January 2018

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TCR/CD3-Induced activation and binding of Emt/Itk to linker of activated T cell complexes: requirement for the Src homology 2 domain.

21 January 2018

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Itk/Emt/Tsk activation in response to CD3 cross-linking in Jurkat T cells requires ZAP-70 and Lat and is independent of membrane recruitment

21 January 2018

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A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2.

21 January 2018

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Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation

21 January 2018

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Severe B cell deficiency in mice lacking the tec kinase family members Tec and Btk.

21 January 2018

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Tec family kinases in lymphocyte signaling and function

21 January 2018

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Imaging immune cell interactions and functions: SMACs and the Immunological Synapse

21 January 2018

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The regulation of actin remodeling during T-cell-APC conjugate formation

21 January 2018

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Vav proteins, adaptors and cell signaling.

21 January 2018

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Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction

21 January 2018

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The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte-antigen-presenting cell interface

21 January 2018

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Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

21 January 2018

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Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton.

21 January 2018

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Differential roles of Lck and Itk in T cell response to antigen recognition revealed by calcium imaging and electron microscopy.

21 January 2018

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Tec family kinases modulate thresholds for thymocyte development and selection

21 January 2018

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Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways.

21 January 2018

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Tec kinases: shaping T-cell activation through actin

21 January 2018

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The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways

21 January 2018

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SLP-76 coordinates Nck-dependent Wiskott-Aldrich syndrome protein recruitment with Vav-1/Cdc42-dependent Wiskott-Aldrich syndrome protein activation at the T cell-APC contact site

21 January 2018

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Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells

21 January 2018

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A novel functional interaction between Vav and PKCtheta is required for TCR-induced T cell activation.

21 January 2018

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Regulation of CXC chemokine receptor 4-mediated migration by the Tec family tyrosine kinase ITK.

21 January 2018

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Requirement for Tec kinases in chemokine-induced migration and activation of Cdc42 and Rac.

21 January 2018

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Chemotactic factor-induced recruitment and activation of Tec family kinases in human neutrophils. Implication of phosphatidynositol 3-kinases

21 January 2018

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The absence of Itk inhibits positive selection without changing lineage commitment

21 January 2018

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The Tec family of tyrosine kinases in T cells, amplifiers of T cell receptor signals

21 January 2018

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Signaling pathways in Th2 development

21 January 2018

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Identification of Rlk, a novel protein tyrosine kinase with predominant expression in the T cell lineage

21 January 2018

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Txk, a nonreceptor tyrosine kinase of the Tec family, is expressed in T helper type 1 cells and regulates interferon gamma production in human T lymphocytes

21 January 2018

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Nuclear localization of the tyrosine kinase Itk and interaction of its SH3 domain with karyopherin alpha (Rch1alpha)

21 January 2018

1 reference

Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription

21 January 2018

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Th1-dominant shift of T cell cytokine production, and subsequent reduction of serum immunoglobulin E response by administration in vivo of plasmid expressing Txk/Rlk, a member of Tec family tyrosine kinases, in a mouse model

21 January 2018

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The regulation of immunity to Leishmania major

21 January 2018

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Asthma: mechanisms of disease persistence and progression

21 January 2018

1 reference

Protein kinase C theta is critical for the development of in vivo T helper (Th)2 cell but not Th1 cell responses

21 January 2018

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Impaired Th2 subset development in the absence of CD4.

21 January 2018

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A role for CD4 in peripheral T cell differentiation

21 January 2018

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CD4 raft association and signaling regulate molecular clustering at the immunological synapse site

21 January 2018

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The immunological synapse: a molecular machine controlling T cell activation

21 January 2018

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Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells

21 January 2018

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Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.

21 January 2018

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Interleukin 2 plays a central role in Th2 differentiation.

21 January 2018

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The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production

21 January 2018

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A role for the Tec family tyrosine kinase Txk in T cell activation and thymocyte selection

21 January 2018

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Regulation of naive T cell differentiation by varying the potency of TCR signal transduction

21 January 2018

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The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model

21 January 2018

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Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells

21 January 2018

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Role of TCR-induced extracellular signal-regulated kinase activation in the regulation of early IL-4 expression in naive CD4+ T cells

21 January 2018

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Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development.

21 January 2018

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An enhanced immune response in mice lacking the transcription factor NFAT1.

21 January 2018

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Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice

21 January 2018

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The potency of TCR signaling differentially regulates NFATc/p activity and early IL-4 transcription in naive CD4+ T cells

21 January 2018

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Induction of T helper type 2 immunity by a point mutation in the LAT adaptor

21 January 2018

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A LAT mutation that inhibits T cell development yet induces lymphoproliferation

21 January 2018

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T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.

21 January 2018

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NK T cell precursors exhibit differential cytokine regulation and require Itk for efficient maturation

21 January 2018

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Cutting edge: the ontogeny and function of Va14Ja18 natural T lymphocytes require signal processing by protein kinase C theta and NF-kappa B.

21 January 2018

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Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells.

21 January 2018

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CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line

21 January 2018

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Tec kinase is involved in transcriptional regulation of IL-2 and IL-4 in the CD28 pathway

21 January 2018

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Itk negatively regulates induction of T cell proliferation by CD28 costimulation

21 January 2018

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CD28 as a molecular amplifier extending TCR ligation and signaling capabilities.

21 January 2018

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Positive feedback regulation of PLCgamma1/Ca(2+) signaling by PKCtheta in restimulated T cells via a Tec kinase-dependent pathway.

21 January 2018

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Tec kinase migrates to the T cell-APC interface independently of its pleckstrin homology domain

21 January 2018

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Molecular and biological actions of cyclosporin A and FK506 on T cell development and function

21 January 2018

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PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

21 January 2018

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Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes

21 January 2018

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Mutation of Tec family kinases alters T helper cell differentiation

31 March 2020

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Vav1: a key signal transducer downstream of the TCR

31 March 2020

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The transcription factor Bright associates with Bruton's tyrosine kinase, the defective protein in immunodeficiency disease

31 March 2020

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Differential regulation of Th2 and Th1 lung inflammatory responses by protein kinase C theta

31 March 2020

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Defective immunoglobulin class switching in Vav-deficient mice is attributable to compromised T cell help

31 March 2020

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Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc

31 March 2020

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A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation

31 March 2020

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SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1

31 March 2020

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NFATc1 and NFATc2 together control both T and B cell activation and differentiation

31 March 2020

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Vav-1 regulates NK T cell development and NK cell cytotoxicity

31 March 2020

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A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

31 March 2020

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Antiviral immune responses in Itk-deficient mice.

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI1591

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Dimensions Publication ID

12 August 2017

1008998872

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