Wikidata

(Q2458503)

English

integrin subunit beta 2

mammalian protein found in Homo sapiens

  • leukocyte cell adhesion molecule CD18
  • leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C
  • ITGB2
  • integrin beta chain, beta 2
  • Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta
  • integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
  • complement component 3 receptor 3 and 4 subunit
  • cell surface adhesion glycoprotein (LFA-1/CR3/P150,959 beta subunit precursor)
  • Complement receptor C3 subunit beta
  • complement receptor C3 beta-subunit
  • integrin beta-2
  • CD18 Antigens
In more languages

Statements

molecular function
protein binding
determination method
IPI
13 references
retrieved
23 May 2017
stated in
Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P05107
determination method
IPI
retrieved
8 April 2019
stated in
Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes
GOA
curator
UniProt
UniProt protein ID
P05107
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107
determination method
IPI
retrieved
8 April 2019
stated in
CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation
GOA
curator
UniProt
UniProt protein ID
P05107
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107
determination method
IPI
retrieved
8 April 2019
stated in
Identification and characterization of multiple similar ligand-binding repeats in filamin: implication on filamin-mediated receptor clustering and cross-talk
GOA
curator
UniProt
UniProt protein ID
P05107
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107
determination method
IPI
retrieved
8 April 2019
stated in
Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated PR3-ANCA neutrophil activation
GOA
curator
UniProt
UniProt protein ID
P05107
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107
determination method
IPI
retrieved
8 April 2019
stated in
c-Abl kinase is required for beta 2 integrin-mediated neutrophil adhesion
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107
determination method
IPI
retrieved
8 April 2019
stated in
Cytoskeletal protein radixin activates integrin alpha(M)beta(2) by binding to its cytoplasmic tail
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107
determination method
IPI
retrieved
8 April 2019
stated in
Widespread macromolecular interaction perturbations in human genetic disorders
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107
determination method
IPI
retrieved
8 April 2019
stated in
Structure of an integrin with an αI domain, complement receptor type 4
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107
determination method
IPI
retrieved
8 April 2019
stated in
Requirement of open headpiece conformation for activation of leukocyte integrin alphaXbeta2.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107
determination method
IPI
retrieved
8 April 2019
stated in
Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107
determination method
IPI
retrieved
8 April 2019
stated in
Characterization of L-plastin interaction with beta integrin and its regulation by micro-calpain
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107
determination method
IPI
cell component
cell surface
determination method
IDA
IEA
6 references
retrieved
23 May 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P05107
determination method
IEA
retrieved
23 May 2017
stated in
Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels
GOA
curator
UniProt
UniProt protein ID
P05107
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P05107
determination method
IDA
retrieved
23 May 2017
stated in
A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans
GOA
curator
UniProt
UniProt protein ID
P05107
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P05107
determination method
IDA
retrieved
23 May 2017
stated in
Mycobacterium tuberculosis infection of human dendritic cells decreases integrin expression, adhesion and migration to chemokines
GOA
curator
UniProt
UniProt protein ID
P05107
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P05107
determination method
IDA
retrieved
23 May 2017
stated in
Disruption of the integrin alphaLbeta2 transmembrane domain interface by beta2 Thr-686 mutation activates alphaLbeta2 and promotes micro-clustering of the alphaL subunits
GOA
curator
UniProt
UniProt protein ID
P05107
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P05107
determination method
IDA
retrieved
23 May 2017
stated in
CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P05107
determination method
IDA
cell surface
determination method
HDA
IBA
IDA
IEA
7 references
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107
determination method
IEA
retrieved
8 April 2019
stated in
Disruption of the integrin alphaLbeta2 transmembrane domain interface by beta2 Thr-686 mutation activates alphaLbeta2 and promotes micro-clustering of the alphaL subunits
GOA
curator
UniProt
UniProt protein ID
P05107
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107
determination method
IDA
retrieved
8 April 2019
stated in
Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels
GOA
curator
UniProt
UniProt protein ID
P05107
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107
determination method
IDA
retrieved
8 April 2019
stated in
A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans
GOA
curator
UniProt
UniProt protein ID
P05107
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107
determination method
IDA
retrieved
8 April 2019
stated in
CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107
determination method
IBA
retrieved
8 April 2019
stated in
Mycobacterium tuberculosis infection of human dendritic cells decreases integrin expression, adhesion and migration to chemokines
GOA
curator
UniProt
UniProt protein ID
P05107
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107
determination method
HDA
biological process
integrin-mediated signaling pathway
determination method
IBA
IEA
IMP
NAS
TAS
6 references
retrieved
8 April 2019
stated in
Zymosan-induced IL-8 release from human neutrophils involves activation via the CD11b/CD18 receptor and endogenous platelet-activating factor as an autocrine modulator
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107
determination method
TAS
retrieved
8 April 2019
stated in
A role for Syk-kinase in the control of the binding cycle of the beta2 integrins (CD11/CD18) in human polymorphonuclear neutrophils
GOA
curator
UniProt
UniProt protein ID
P05107
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107
determination method
NAS
retrieved
8 April 2019
stated in
CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation
GOA
curator
UniProt
UniProt protein ID
P05107
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P05107
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107
determination method
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107
determination method
IBA
Gene Atlas image
PBB GE ITGB2 202803 s at fs.png
732 × 530; 10 KB
0 references

Identifiers

MeSH descriptor ID
D018821
subject named as
CD18 Antigens
0 references
Ensembl protein ID
PDB structure ID
 
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