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Cucurbitacins - a promising target for cancer therapy
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title
Cucurbitacins - a promising target for cancer therapy
(English)
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author name string
Abdullah A Alghasham
series ordinal
1
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language of work or name
English
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publication date
January 2013
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published in
International journal of health sciences
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stated in
PubMed
volume
7
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issue
1
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page(s)
77-89
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cites work
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Biological activities and potential molecular targets of cucurbitacins: a focus on cancer
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Synthesis and cytotoxic activity evaluation of dihydrocucurbitacin B and cucurbitacin B derivatives.
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Cucurbitacins as inducers of cell death and a rich source of potential anticancer compounds.
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In vitro and in vivo study of cucurbitacins-type triterpene glucoside from Citrullus colocynthis growing in Saudi Arabia against hepatocellular carcinoma
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Isolation, structure elucidation, and biological evaluation of 16,23-epoxycucurbitacin constituents from Eleaocarpus chinensis.
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27 September 2017
Effects of cucurbitacins on cell morphology are associated with sensitization of renal carcinoma cells to TRAIL-induced apoptosis
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27 September 2017
Inhibition of Wnt signaling by cucurbitacin B in breast cancer cells: reduction of Wnt-associated proteins and reduced translocation of galectin-3-mediated β-catenin to the nucleus.
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27 September 2017
Apoptosis induction through proteasome inhibitory activity of cucurbitacin D in human T-cell leukemia
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27 September 2017
Cucurbitacin B has a potent antiproliferative effect on breast cancer cells in vitro and in vivo
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27 September 2017
Activated kRas protects colon cancer cells from cucurbitacin-induced apoptosis: the role of p53 and p21.
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27 September 2017
JSI-124 inhibits glioblastoma multiforme cell proliferation through G(2)/M cell cycle arrest and apoptosis augment
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27 September 2017
Stat3 promotes metastatic progression of prostate cancer.
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27 September 2017
Combined antitumor activity of cucurbitacin B and docetaxel in laryngeal cancer
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Cucurbitacin I inhibits Stat3 and induces apoptosis in Sézary cells
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Cucurbitacin glucosides: antioxidant and free-radical scavenging activities
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Polymeric micelles for the solubilization and delivery of STAT3 inhibitor cucurbitacins in solid tumors.
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27 September 2017
Cucurbitacin R reduces the inflammation and bone damage associated with adjuvant arthritis in lewis rats by suppression of tumor necrosis factor-alpha in T lymphocytes and macrophages.
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27 September 2017
Growth inhibitory activity of cucurbitacin glucosides isolated from Citrullus colocynthis on human breast cancer cells
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27 September 2017
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27 September 2017
Cucurbitacins and cucurbitane glycosides: structures and biological activities
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Immunomodulatory activity of cucurbitacin E isolated from Ecballium elaterium
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Stat3 activity in melanoma cells affects migration of immune effector cells and nitric oxide-mediated antitumor effects
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Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity
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Constitutive activation of STAT3 and STAT5 is present in the majority of nasopharyngeal carcinoma and correlates with better prognosis
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27 September 2017
Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells
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Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice
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Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells
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27 September 2017
Stat proteins and oncogenesis
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27 September 2017
Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis
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27 September 2017
Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling
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27 September 2017
Inhibition of T-lymphocyte proliferation by cucurbitacins from Picrorhiza scrophulariaeflora
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27 September 2017
ErbB-2 kinase is required for constitutive stat 3 activation in malignant human lung epithelial cells
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27 September 2017
Negative regulation of the JAK/STAT pathway
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27 September 2017
Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells
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27 September 2017
Cucurbitacin E targets proliferating endothelia
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27 September 2017
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27 September 2017
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27 September 2017
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27 September 2017
Cucurbitacin B induces differentiation, cell cycle arrest, and actin cytoskeletal alterations in myeloid leukemia cells
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Relationship between cucurbitacins reversed-phase high-performance liquid chromatography hydrophobicity index and basal cytotoxicity on HepG2 cells
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30 May 2018
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30 May 2018
Cucurbitacin E-induced disruption of the actin and vimentin cytoskeleton in prostate carcinoma cells.
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30 May 2018
Dihydrocucurbitacin B inhibits delayed type hypersensitivity reactions by suppressing lymphocyte proliferation.
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28 November 2018
JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells.
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28 November 2018
Inhibition of nitric oxide generation by 23,24-dihydrocucurbitacin D in mouse peritoneal macrophages.
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28 November 2018
Anticancer and antiinflammatory activities of cucurbitacins from Cucurbita andreana
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28 November 2018
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28 November 2018
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28 November 2018
Activation of Stat-3 as one of the early events in tobacco chewing-mediated oral carcinogenesis.
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28 November 2018
EGFR dependent expression of STAT3 (but not STAT1) in breast cancer
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28 November 2018
Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells
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based on heuristic
inferred from PubMed ID database lookup
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Identifiers
DOI
10.12816/0006025
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Fatcat ID
release_nejl5ox6mzf2rcscw2ar6tkcvm
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PMCID
3612419
0 references
PubMed ID
23559908
0 references
ResearchGate publication ID
236115141
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