(Q24600932)

1

0 references

Alberto Bardelli

18

0 references

Mariangela Russo

Mariangela Russo

7

0 references

Sabrina Arena

Sabrina Arena

2

0 references

Stefano Biffo

Stefano Biffo

17

0 references

Josep Tabernero Caturla

Josep Tabernero

3

0 references

Davide Zecchin

9

Davide Zecchin

0 references

author name string

Stefano Grosso

4

0 references

Francesca Molinari

5

0 references

Teresa Macarulla

6

0 references

Carlotta Cancelliere

8

0 references

Luca Mazzucchelli

10

0 references

Takehiko Sasazuki

11

0 references

Senji Shirasawa

12

0 references

Massimo Geuna

13

0 references

Milo Frattini

14

0 references

José Baselga

15

0 references

Margherita Gallicchio

Journal of Clinical Investigation

16

0 references

language of work or name

English

0 references

publication date

August 2010

0 references

published in

0 references

volume

120

0 references

issue

8

0 references

page(s)

2858-66

0 references

cites work

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1 reference

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Replacement of normal with mutant alleles in the genome of normal human cells unveils mutation-specific drug responses

7 April 2017

1 reference

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The RSK family of kinases: emerging roles in cellular signalling

7 April 2017

1 reference

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New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada

7 April 2017

1 reference

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Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation

7 April 2017

1 reference

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Current development of mTOR inhibitors as anticancer agents

7 April 2017

1 reference

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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

7 April 2017

1 reference

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Molecular mechanisms of mTOR-mediated translational control

7 April 2017

1 reference

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Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

7 April 2017

1 reference

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Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial

7 April 2017

1 reference

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Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma

7 April 2017

1 reference

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Exploiting the PI3K/AKT pathway for cancer drug discovery

7 April 2017

1 reference

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Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment

7 April 2017

1 reference

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Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer

27 September 2017

1 reference

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AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

27 September 2017

1 reference

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Phase 2 trial of erlotinib plus sirolimus in adults with recurrent glioblastoma

27 September 2017

1 reference

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Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells

27 September 2017

1 reference

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Novel agents on the horizon for cancer therapy

27 September 2017

1 reference

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AGC kinases regulate phosphorylation and activation of eukaryotic translation initiation factor 4B.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912177

Enhancing mammalian target of rapamycin (mTOR)-targeted cancer therapy by preventing mTOR/raptor inhibition-initiated, mTOR/rictor-independent Akt activation

27 September 2017

1 reference

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Phase I pharmacokinetic and pharmacodynamic study of the oral mammalian target of rapamycin inhibitor everolimus in patients with advanced solid tumors

27 September 2017

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Identifying optimal biologic doses of everolimus (RAD001) in patients with cancer based on the modeling of preclinical and clinical pharmacokinetic and pharmacodynamic data

27 September 2017

1 reference

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PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients

27 September 2017

1 reference

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mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912177

RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912177

Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912177

Mutant PIK3CA promotes cell growth and invasion of human cancer cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912177

A genetically defined mouse ovarian carcinoma model for the molecular characterization of pathway-targeted therapy and tumor resistance

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912177

Isogenic mutant human cells: a new tool for personalized cancer medicine.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912177

Altered growth of human colon cancer cell lines disrupted at activated Ki-ras

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912177

PKCbetaII modulates translation independently from mTOR and through RACK1.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912177

Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912177

Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912177

Colorectal cancer: mutations in a signalling pathway

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912177

Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912177

28 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/20664172

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Phase I/II study of the mammalian target of rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20664172

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Clinical relevance of "late" in the management of late relapse after treatment for a germ cell tumor

1 reference

Crossref

https://api.crossref.org/works/10.1172%2FJCI37539