(Q24606434)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16299240%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

title

Phase II trial of oral aminopterin for adults and children with refractory acute leukemia (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16299240%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

main subject

phase II clinical trial

0 references

1 reference

1 reference

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16299240%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

author name string

Peter D Cole

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16299240%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Richard A Drachtman

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16299240%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Angela K Smith

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16299240%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Sarah Cate

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16299240%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Douglas S Hawkins

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16299240%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

John Holcenberg

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16299240%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Kara Kelly

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16299240%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Barton A Kamen

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16299240%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

language of work or name

English

0 references

publication date

1 November 2005

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16299240%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

published in

Clinical Cancer Research

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16299240%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

volume

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16299240%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

issue

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16299240%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

page(s)

8089-8096

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16299240%20AND%20SRC:MED&resulttype=core&format=json

Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid

9 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906753

A quantitative comparison of the antileukemic effectiveness of two folic acid antagonists in mice

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906753

Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906753

Mechanisms of methotrexate resistance in acute leukemia. Decreased transport and polyglutamylation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906753

Phase I and pharmacokinetic trial of aminopterin in patients with refractory malignancies

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906753

Intermediate-dose intravenous methotrexate with intravenous mercaptopurine is superior to repetitive low-dose oral methotrexate with intravenous mercaptopurine for children with lower-risk B-lineage acute lymphoblastic leukemia: a Pediatric Oncology

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906753

Intrinsic and acquired resistance to methotrexate in acute leukemia.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906753

Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo. A rationale for high-dose methotrexate

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906753

Karnofsky memorial lecture. Ode to methotrexate

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906753

Intracellular pharmacokinetics of methotrexate polyglutamates in human breast cancer cells. Selective retention and less dissociable binding of 4-NH2-10-CH3-pteroylglutamate4 and 4-NH2-10-CH3-pteroylglutamate5 to dihydrofolate reductase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906753

A Phase 1 study of high doses of aminopterin with leucovorin rescue in patients with advanced metastatic tumors

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906753

Unpredictable serum levels after oral methotrexate in children with acute lymphoblastic leukaemia

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906753

Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906753

Decreased polyglutamylation of methotrexate in acute lymphoblastic leukemia blasts in adults compared to children with this disease.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906753

Mammalian folylpoly-gamma-glutamate synthetase. 3. Specificity for folate analogues

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906753

Cytotoxicity, uptake, polyglutamate formation, and antileukemic effects of 8-deaza analogues of methotrexate and aminopterin in mice

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906753

Analysis of methotrexate polyglutamate derivatives in vivo

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906753

Accumulation of methotrexate and methotrexate polyglutamates in lymphoblasts at diagnosis of childhood acute lymphoblastic leukemia: a pilot prognostic factor analysis

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906753

A rapid, radiochemical-ligand binding assay for methotrexate

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906753

Aminopterin in the treatment of acute leukaemia.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906753

Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906753

Differences in folylpolyglutamate synthetase and dihydrofolate reductase expression in human B-lineage versus T-lineage leukemic lymphoblasts: mechanisms for lineage differences in methotrexate polyglutamylation and cytotoxicity

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906753

Pharmacokinetics of oral methotrexate in children.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2906753

Studies on the mechanism of action of chemotherapeutic agents in cancer. VI. Synergistic (additive) action of drugs on a transplantable leukemia in mice

28 November 2018

1 reference

12 December 2020

Studies on the chemotherapy of leukemia; the effect of 4-amino-pteroylglutamic acid and 4-amino-N10-methyl-pteroylglutamic acid on transplanted mouse leukemia

1 reference

12 December 2020

The effect of folic acid fortification on plasma folate and total homocysteine concentrations

1 reference

12 December 2020

Treatment of leukemia with aminopterin

1 reference

12 December 2020

Aminopterin, a folic acid antagonist, in the treatment of leukemia

1 reference

12 December 2020

Folic acid antagonists in the treatment of acute and subacute leukemia

1 reference

12 December 2020

Intensive oral methotrexate protects against lymphoid marrow relapse in childhood B-precursor acute lymphoblastic leukemia

1 reference

12 December 2020

Effects of food supplementation and education on folate stores

1 reference

12 December 2020

Folate analogues as substrates of mammalian folylpolyglutamate synthetase

1 reference

12 December 2020

THE PURIFICATION OF AMINOPTERIN

1 reference

12 December 2020

A case for the use of aminopterin in treatment of patients with leukemia based on metabolic studies of blasts in vitro

1 reference

12 December 2020

Differences in constitutive and post-methotrexate folylpolyglutamate synthetase activity in B-lineage and T-lineage leukemia

1 reference

12 December 2020

Observations on acute leukemia in children treated with 4-aminopteroylglutamic acid

1 reference

12 December 2020

Efflux of methotrexate and its polyglutamate derivatives from hepatic cells in vitro

1 reference

12 December 2020

Disparate affinities of antifolates for folylpolyglutamate synthetase from human leukemia cells

1 reference

12 December 2020

Methotrexate Polyglutamates in Cultured Human Cells

1 reference

12 December 2020

Structural features of 4-amino antifolates required for substrate activity with mammalian folylpolyglutamate synthetase

1 reference

12 December 2020

Amelioration of methotrexate-induced malabsorption by vitamin A

1 reference

12 December 2020

Methotrexate bioavailability after oral and intramuscular administration in children

1 reference

12 December 2020

1 reference

12 December 2020

Observations on the effects of the folic acid antagonists, aminopterin and amethopterin, in patients with advanced neoplasms

1 reference

12 December 2020

The response of acute leukemia to the administration of the folic acid antagonists, aminopterin and a-methopterin; report of 14 cases

1 reference

12 December 2020

Basis for natural resistance to methotrexate in human acute non-lymphocytic leukemia

1 reference

12 December 2020

10.1158/1078-0432.CCR-05-0355

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16299240%20AND%20SRC:MED&resulttype=core&format=json

release_zzcwfxdnz5gxbpohxgwtaug24a

9 January 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/zzcwfxdnz5gxbpohxgwtaug24a

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16299240%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

PubMed publication ID

16299240

1 reference