(Q24615907)

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Synthesis of quinoline derivatives: discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's disease

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scholarly article

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Synthesis of quinoline derivatives: discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's disease (English)

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organic chemistry

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Alzheimer's disease

1 reference

based on heuristic

inferred from title

object named as

Jole Fiorito

1

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Ottavio Arancio

object named as

Ottavio Arancio

11

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author name string

Faisal Saeed

2

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Hong Zhang

3

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Agnieszka Staniszewski

4

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Yan Feng

5

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Yitshak I Francis

6

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Sudha Rao

7

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Devarshi M Thakkar

8

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Shi-Xian Deng

9

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Donald W Landry

10

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language of work or name

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publication date

February 2013

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European Journal of Medicinal Chemistry

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60

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285-94

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582828

7 April 2017

Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior

1 reference

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7 April 2017

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

1 reference

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7 April 2017

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

1 reference

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7 April 2017

Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

1 reference

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7 April 2017

Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments

1 reference

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27 September 2017

Phosphodiesterase-5 inhibitors: novel weapons against Alzheimer's disease?

1 reference

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27 September 2017

Cyclic GMP and nitric oxide synthase in aging and Alzheimer's disease.

1 reference

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27 September 2017

Role of phosphodiesterase 5 in synaptic plasticity and memory

1 reference

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27 September 2017

Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory

1 reference

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27 September 2017

beta-Amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or beta-amyloid deposits.

1 reference

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Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment

1 reference

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Phosphodiesterase type 5 inhibition improves early memory consolidation of object information

1 reference

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Tissue expression, distribution, and regulation of PDE5.

1 reference

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1 reference

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Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling

1 reference

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27 September 2017

Pharmacology of phosphodiesterase-5 inhibitors.

1 reference

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IC351 (tadalafil, Cialis): update on clinical experience

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4-(3-Chloro-4-methoxybenzyl)aminophthalazines: synthesis and inhibitory activity toward phosphodiesterase 5.

1 reference

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27 September 2017

Mechanisms of synaptic dysfunction in Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582828

27 September 2017

Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-beta load in an Alzheimer's disease mouse model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582828

28 November 2018

Likelihood of tadalafil-associated adverse events in integrated multiclinical trial database: classification tree analysis in men with erectile dysfunction

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28 November 2018

Two-day radial-arm water maze learning and memory task; robust resolution of amyloid-related memory deficits in transgenic mice.

1 reference

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28 November 2018

Amyloid-beta peptide inhibits activation of the nitric oxide/cGMP/cAMP-responsive element-binding protein pathway during hippocampal synaptic plasticity.

1 reference

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Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice.

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28 November 2018

Species differences in the localization of cGMP-producing and NO-responsive elements in the mouse and rat hippocampus using cGMP immunocytochemistry.

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28 November 2018

Quinolines as extremely potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction

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Novel, potent, and selective phosphodiesterase 5 inhibitors: synthesis and biological activities of a series of 4-aryl-1-isoquinolinone derivatives

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1 reference

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28 November 2018

Generation of aggregated beta-amyloid in the rat hippocampus impairs synaptic transmission and plasticity and causes memory deficits

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substituted pyrazolopyridines as potent and selective PDE5 inhibitors: potential agents for treatment of erectile dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/23313637

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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