(Q24625355)

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Design and synthesis of an orally active metabotropic glutamate receptor subtype-2 (mGluR2) positive allosteric modulator (PAM) that decreases cocaine self-administration in rats

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Europe PubMed Central

PubMed publication ID

21 June 2017

Design and synthesis of an orally active metabotropic glutamate receptor subtype-2 (mGluR2) positive allosteric modulator (PAM) that decreases cocaine self-administration in rats (English)

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Europe PubMed Central

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21 June 2017

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P. Jeffrey Conn

11

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P Jeffrey Conn

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21 June 2017

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Raveendra-Panickar Dhanya

1

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21 June 2017

Shyama Sidique

2

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21 June 2017

Douglas J Sheffler

3

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21 June 2017

Hilary Highfield Nickols

4

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21 June 2017

Ananda Herath

5

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21 June 2017

Li Yang

6

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21 June 2017

Russell Dahl

7

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21 June 2017

Robert Ardecky

8

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21 June 2017

Svetlana Semenova

9

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21 June 2017

Athina Markou

10

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21 June 2017

Nicholas D P Cosford

12

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21 June 2017

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publication date

14 December 2010

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21 June 2017

Journal of Medicinal Chemistry

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21 June 2017

54

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21 June 2017

1

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21 June 2017

342-353

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21 June 2017

The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in rats

1 reference

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Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs)

1 reference

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Glutamatergic substrates of drug addiction and alcoholism

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Regulation of neurotransmitter release by metabotropic glutamate receptors

1 reference

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Pharmacology and functions of metabotropic glutamate receptors

1 reference

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The identification of structurally novel, selective, orally bioavailable positive modulators of mGluR2.

1 reference

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Scaffold hopping from pyridones to imidazo[1,2-a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor.

1 reference

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The glutamate homeostasis hypothesis of addiction

1 reference

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Glutamate and reinstatement

1 reference

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Receptor activation involving positive allosteric modulation, unlike full agonism, does not result in GABAB receptor desensitization

1 reference

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The neurocircuitry of addiction: an overview

1 reference

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A novel assay of Gi/o-linked G protein-coupled receptor coupling to potassium channels provides new insights into the pharmacology of the group III metabotropic glutamate receptors

1 reference

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A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors

1 reference

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Metabotropic glutamate receptor antagonists: novel therapeutics for nicotine dependence and depression?

1 reference

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Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice

1 reference

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Biphenyl-indanones: allosteric potentiators of the metabotropic glutamate subtype 2 receptor

1 reference

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Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking

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Neurobiology of craving, conditioned reward and relapse

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The metabotropic glutamate receptor 5 antagonist MPEP decreased break points for nicotine, cocaine and food in rats

1 reference

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27 September 2017

Phenyl-tetrazolyl acetophenones: discovery of positive allosteric potentiatiors for the metabotropic glutamate 2 receptor

1 reference

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The ups and downs of addiction: role of metabotropic glutamate receptors

1 reference

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27 September 2017

Glutamate systems in cocaine addiction

1 reference

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Neuroadaptive mechanisms of addiction: studies on the extended amygdala

1 reference

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Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2.

1 reference

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27 September 2017

Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2- trifluoroethylsulfonyl)pyrid-3-ylmethylamine

1 reference

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27 September 2017

Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens

1 reference

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Cocaine dependence: a disease of the brain's reward centers

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Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons

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Addiction is a brain disease, and it matters

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Distribution of a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat and mouse: an immunohistochemical study with a monoclonal antibody

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Effects of [(N-alkyl-1,3-dioxo-1H,3H-isoindolin-5-yl)oxy]alkanoic acids, [(N-alkyl-1-oxo-1H,3H-isoindolin-5-yl)oxy]butanoic acids, and related derivatives on chloride influx in primary astroglial cultures

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3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts

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3-Benzyl-1,3-oxazolidin-2-ones as mGluR2 positive allosteric modulators: Hit-to lead and lead optimization.

1 reference

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Rats with extended access to cocaine exhibit increased stress reactivity and sensitivity to the anxiolytic-like effects of the mGluR 2/3 agonist LY379268 during abstinence

1 reference

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The mGluR2/3 agonist LY379268 attenuates context- and discrete cue-induced reinstatement of sucrose seeking but not sucrose self-administration in rats

1 reference

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1 reference

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Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 3: Identification and biological activity of indanone containing mGlu2 receptor potentiators

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28 November 2018

Attenuation of behavioral effects of cocaine by the Metabotropic Glutamate Receptor 5 Antagonist 2-Methyl-6-(phenylethynyl)-pyridine in squirrel monkeys: comparison with dizocilpine

1 reference

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Pyrimidine methyl anilines: selective potentiators for the metabotropic glutamate 2 receptor

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Preferential effects of the metabotropic glutamate 2/3 receptor agonist LY379268 on conditioned reinstatement versus primary reinforcement: comparison between cocaine and a potent conventional reinforcer.

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Metabotropic glutamate 5 receptor antagonist MPEP decreased nicotine and cocaine self-administration but not nicotine and cocaine-induced facilitation of brain reward function in rats

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Increased motivation for self-administered cocaine after escalated cocaine intake

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High throughput artificial membrane permeability assay for blood-brain barrier

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Cocaine-seeking behavior after extended cocaine-free periods in rats: role of conditioned stimuli

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Modulation of group II metabotropic glutamate receptor signaling by chronic cocaine

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[3H]LY341495 binding to group II metabotropic glutamate receptors in rat brain

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Long-term potentiation of excitatory inputs to brain reward areas by nicotine.

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Repeated cocaine administration alters extracellular glutamate in the ventral tegmental area.

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28 November 2018

Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 1: Identification and synthesis of phenyl-tetrazolyl acetophenones

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12 December 2020

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Novel alternative for the N-S bond formation and its application to the synthesis of benzisothiazol-3-ones

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https://pubmed.ncbi.nlm.nih.gov/21155570

12 December 2020

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10.1021/JM1012165

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Europe PubMed Central

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21 June 2017

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Consolidated OpenCitations Corpus – April 2017

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Consolidated OpenCitations Corpus – April 2017

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21 June 2017

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