(Q24626329)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20702418%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

title

SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20702418%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

0 references

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20702418%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

author name string

Han Dai

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20702418%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Lauren Kustigian

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20702418%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

David Carney

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20702418%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

April Case

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20702418%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Thomas Considine

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20702418%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Basil P Hubbard

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20702418%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Robert B Perni

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20702418%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Bruce Szczepankiewicz

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20702418%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

George P Vlasuk

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20702418%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Ross L Stein

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20702418%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

language of work or name

English

0 references

publication date

11 August 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20702418%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

9 February 2020

number of pages

9

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20702418%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

volume

285

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20702418%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

issue

43

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20702418%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

page(s)

32695-32703

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20702418%20AND%20SRC:MED&resulttype=core&format=json

SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1

9 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963390

A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963390

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963390

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963390

Resveratrol is not a direct activator of SIRT1 enzyme activity

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963390

Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963390

Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963390

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963390

Mechanism of human SIRT1 activation by resveratrol

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963390

Substrate-specific activation of sirtuins by resveratrol

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963390

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963390

Allosteric Activation of the Hydrolysis of Specific Substrates by Chymotrypsin

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963390

ATP effects on insulin-degrading enzyme are mediated primarily through its triphosphate moiety

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963390

Chemistry of gene silencing: the mechanism of NAD+-dependent deacetylation reactions

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963390

Mammalian sirtuins: biological insights and disease relevance

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963390

Discovery, structure-activity relationships, pharmacokinetics, and efficacy of glucokinase activator (2R)-3-cyclopentyl-2-(4-methanesulfonylphenyl)-N-thiazol-2-yl-propionamide (RO0281675).

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963390

Sirt1 activation protects the mouse renal medulla from oxidative injury

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963390

Resveratrol, sirtuins, and the promise of a DR mimetic

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963390

Turning enzymes ON with small molecules

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963390

SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963390

SRT1720 induces mitochondrial biogenesis and rescues mitochondrial function after oxidant injury in renal proximal tubule cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963390

SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963390

Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963390

A continuous microplate assay for sirtuins and nicotinamide-producing enzymes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963390

Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963390

Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963390

SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963390

Sirtuins in aging and disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963390

The biochemistry of sirtuins.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963390

Allosteric proteins and cellular control systems

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963390

SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963390

Kinetic mechanism of guinea pig neutrophil 5-lipoxygenase.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963390

Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry

30 May 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.133892

Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.133892

Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.133892

Fluorescence assay of SIRT protein deacetylases using an acetylated peptide substrate and a secondary trypsin reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.133892

Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.133892

Allosteric control of the substrate specificity of the anaerobic ribonucleotide reductase from Escherichia coli

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20702418

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M110.133892

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20702418%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20702418%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

2 references