(Q37692161)

22 August 2017

Turning enzymes ON with small molecules (English)

1 reference

22 August 2017

Julie A Zorn

1

1 reference

PubMed ID

20154666

22 August 2017

James A Wells

series ordinal

2

1 reference

22 August 2017

1 March 2010

1 reference

22 August 2017

Nature Chemical Biology

1 reference

22 August 2017

6

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22 August 2017

3

1 reference

22 August 2017

179-188

1 reference

https://scigraph.springernature.com/pub.10.1038/nchembio.318

22 August 2017

0 references

cites work

A physical map of the human genome

1 reference

12 December 2020

Mechanistic and structural insights into the proteolytic activation of Vibrio cholerae MARTX toxin

1 reference

12 December 2020

Small Molecule-Induced Allosteric Activation of the Vibrio cholerae RTX Cysteine Protease Domain

1 reference

12 December 2020

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

1 reference

12 December 2020

The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy

1 reference

12 December 2020

3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds.

1 reference

12 December 2020

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

1 reference

12 December 2020

Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1

1 reference

12 December 2020

A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation

1 reference

12 December 2020

Characteristics necessary for an interconvertible enzyme cascade to generate a highly sensitive response to an effector

1 reference

12 December 2020

Phosphoinositide-dependent protein kinase 1, a sensor of protein conformation

1 reference

12 December 2020

Discovery and SAR development of thienopyridones: a class of small molecule AMPK activators.

1 reference

12 December 2020

Small molecule glucokinase activators as glucose lowering agents: a new paradigm for diabetes therapy

1 reference

12 December 2020

Mechanisms and molecular probes of sirtuins.

1 reference

12 December 2020

Rationally designed peptide regulators of protein kinase C.

1 reference

12 December 2020

The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.

1 reference

12 December 2020

Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status.

1 reference

12 December 2020

Competitive inhibitors and allosteric activators of protein kinase C isoenzymes: a personal account and progress report on transferring academic discoveries to the clinic

1 reference

12 December 2020

Sirtuins in aging and age-related disease.

1 reference

12 December 2020

Small molecules not direct activators of caspases

1 reference

12 December 2020

Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae

1 reference

12 December 2020

Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding

1 reference

12 December 2020

Signaling through cAMP and cAMP-dependent protein kinase: diverse strategies for drug design.

1 reference

12 December 2020

Biophysical characterization of the interaction between hepatic glucokinase and its regulatory protein: impact of physiological and pharmacological effectors

1 reference

12 December 2020

SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1

1 reference

12 December 2020

Substrate-specific activation of sirtuins by resveratrol

1 reference

12 December 2020

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

1 reference

12 December 2020

Molecular basis for recognition of 2',5'-linked oligoadenylates by the N-terminal ankyrin repeat domain of human ribonuclease L.

1 reference

12 December 2020

AMPK: an emerging drug target for diabetes and the metabolic syndrome

1 reference

12 December 2020

Autocatalytic cleavage of Clostridium difficile toxin B.

1 reference

12 December 2020

Structural insight into the autoinhibition mechanism of AMP-activated protein kinase

1 reference

12 December 2020

Chemical strategies for the global analysis of protein function

1 reference

12 December 2020

Assessing the potential of glucokinase activators in diabetes therapy

1 reference

12 December 2020

The Jekyll and Hyde functions of caspases

1 reference

12 December 2020

Auto-catalytic cleavage of Clostridium difficile toxins A and B depends on cysteine protease activity.

1 reference

12 December 2020

Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart

1 reference

12 December 2020

Caspase-activation pathways in apoptosis and immunity

2 references

12 December 2020

Crossref

https://api.crossref.org/works/10.1038%2FNCHEMBIO.318

7 January 2021

inferred from DOI database lookup

Inhibitor hijacking of Akt activation

1 reference

12 December 2020

Allosteric activators of glucokinase: potential role in diabetes therapy

1 reference

12 December 2020

2-5A induces a conformational change in the ankyrin-repeat domain of RNase L.

1 reference

12 December 2020

1 reference

12 December 2020

Allosteric activation of the protein kinase PDK1 with low molecular weight compounds

1 reference

12 December 2020

Assay principle for modulators of protein-protein interactions and its application to non-ATP-competitive ligands targeting protein kinase A.

1 reference

12 December 2020

Maintenance of caspase-3 proenzyme dormancy by an intrinsic "safety catch" regulatory tripeptide

1 reference

12 December 2020

Crystal structures of the adenylate sensor from fission yeast AMP-activated protein kinase

1 reference

12 December 2020

Structural basis for recognition of 2',5'-linked oligoadenylates by human ribonuclease L.

1 reference

12 December 2020

Structural basis for AMP binding to mammalian AMP-activated protein kinase

1 reference

12 December 2020

Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase

1 reference

12 December 2020

Negative regulation of the deacetylase SIRT1 by DBC1

1 reference

12 December 2020

Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA

1 reference

12 December 2020

The Sirtuin family: therapeutic targets to treat diseases of aging

1 reference

12 December 2020

Contribution of Non-catalytic Core Residues to Activity and Regulation in Protein Kinase A

1 reference

12 December 2020

The conformational plasticity of protein kinases

1 reference

12 December 2020

Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

1 reference

12 December 2020

Recent progress in the biology and physiology of sirtuins

1 reference

12 December 2020

Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy

1 reference

12 December 2020

AMP-activated protein kinase as a drug target.

1 reference

12 December 2020

Interferon action--sequence specificity of the ppp(A2'p)nA-dependent ribonuclease.

1 reference

12 December 2020

A common allosteric site and mechanism in caspases

1 reference

12 December 2020

The Enzymatic Synthesis of 5-Amino-4-Imidazolecarboxamide Riboside Triphosphate (ZTP)

1 reference

12 December 2020

Implications for RNase L in prostate cancer biology

1 reference

12 December 2020

Sensitivity amplification in biochemical systems

1 reference

12 December 2020

Mammalian caspases: structure, activation, substrates, and functions during apoptosis

1 reference

12 December 2020

Components of the cell death machine and drug sensitivity of the National Cancer Institute Cell Line Panel.

1 reference

12 December 2020

Chemical genetics: ligand-based discovery of gene function

1 reference

12 December 2020

Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1

1 reference

12 December 2020

Structure-function analysis of inositol hexakisphosphate-induced autoprocessing of the Vibrio cholerae multifunctional autoprocessing RTX toxin

1 reference

12 December 2020

Bypassing a Kinase Activity with an ATP-Competitive Drug

1 reference

12 December 2020

Glucokinase regulatory protein is essential for the proper subcellular localisation of liver glucokinase

1 reference

12 December 2020

DBC1 is a negative regulator of SIRT1

1 reference

12 December 2020

Small-molecule activators of a proenzyme

1 reference

12 December 2020

Caspases - controlling intracellular signals by protease zymogen activation

1 reference

12 December 2020

Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae

1 reference

12 December 2020

High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site

1 reference

12 December 2020

Functional domains of the alpha1 catalytic subunit of the AMP-activated protein kinase

1 reference

12 December 2020

Sirtuins--novel therapeutic targets to treat age-associated diseases

1 reference

12 December 2020

Structural and Molecular Mechanism for Autoprocessing of MARTX Toxin of Vibrio cholerae at Multiple Sites

1 reference

12 December 2020

Glucose modulation of glucokinase activation by small molecules

1 reference

12 December 2020

The Sequence of the Human Genome

1 reference

12 December 2020

Pharmacologic modulation of protein kinase C isozymes: the role of RACKs and subcellular localisation

1 reference

12 December 2020

Human caspases: activation, specificity, and regulation

1 reference

12 December 2020

Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3

1 reference

12 December 2020

Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family.

1 reference

12 December 2020

Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.

1 reference

12 December 2020

Chemical genetic approaches for the elucidation of signaling pathways

1 reference

12 December 2020

Activation of protein phosphatase 1 by a small molecule designed to bind to the enzyme's regulatory site

1 reference

12 December 2020

Response coefficients of interconvertible enzyme cascades towards effectors that act on one or both modifier enzymes.

1 reference

12 December 2020

Recent advances in glucokinase activators for the treatment of type 2 diabetes

1 reference

12 December 2020

PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition

1 reference

12 December 2020

Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes.

1 reference

12 December 2020

5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?

1 reference

12 December 2020

Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells

1 reference

12 December 2020

Discovery of an allosteric site in the caspases

1 reference

12 December 2020

Small molecule modulators of histone acetyltransferase p300.

1 reference

12 December 2020

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

1 reference

12 December 2020

Evolution and regulatory role of the hexokinases

1 reference

12 December 2020

Protein-protein interactions in the allosteric regulation of protein kinases

1 reference

12 December 2020

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

1 reference

12 December 2020

Sir2-independent life span extension by calorie restriction in yeast

1 reference

12 December 2020

Structural basis for the activation of human procaspase-7

1 reference

12 December 2020

Brought to life: targeted activation of enzyme function with small molecules

1 reference

12 December 2020

Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships

1 reference

12 December 2020

PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation

1 reference

12 December 2020

Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity

1 reference

12 December 2020

Identification of fructose 6-phosphate- and fructose 1-phosphate-binding residues in the regulatory protein of glucokinase

1 reference

12 December 2020

Functional characterization of 2',5'-linked oligoadenylate binding determinant of human RNase L.

1 reference

12 December 2020

Small-molecule activators of RNase L with broad-spectrum antiviral activity

1 reference

12 December 2020

Two-state selection of conformation-specific antibodies

1 reference

12 December 2020

Autocatalytic processing of Clostridium difficile toxin B. Binding of inositol hexakisphosphate

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO.318

1 reference

22 August 2017

1 reference

PubMed ID

20154666