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Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy
scientific article
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instance of
scholarly article
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review article
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stated in
Europe PubMed Central
title
Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy
(English)
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author name string
C A Sparks
series ordinal
1
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D A Guertin
series ordinal
2
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language of work or name
English
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publication date
1 July 2010
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published in
Oncogene
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volume
29
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page(s)
3733-44
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issue
26
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cites work
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mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s
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27 September 2017
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27 September 2017
Rapamycin regulates the phosphorylation of rictor
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27 September 2017
Classical PKC isoforms in cancer
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27 September 2017
PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR
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27 September 2017
Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML.
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27 September 2017
Inhibition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway in hematologic malignancies.
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27 September 2017
The phosphatidylinositol 4,5-biphosphate and TORC2 binding proteins Slm1 and Slm2 function in sphingolipid regulation
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27 September 2017
TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity
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27 September 2017
Serum and glucocorticoid-regulated protein kinases: variations on a theme
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27 September 2017
Drosophila target of rapamycin kinase functions as a multimer.
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27 September 2017
mTOR, a new therapeutic target in acute myeloid leukemia
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27 September 2017
TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium
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27 September 2017
Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma
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27 September 2017
The human stress-activated protein kinase-interacting 1 gene encodes JNK-binding proteins
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27 September 2017
The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation
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27 September 2017
Identification of a conserved motif required for mTOR signaling
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27 September 2017
A novel Ras-interacting protein required for chemotaxis and cyclic adenosine monophosphate signal relay in Dictyostelium
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27 September 2017
AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity
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30 May 2018
Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth
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30 May 2018
Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin.
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30 May 2018
The pharmacology of mTOR inhibition
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28 November 2018
RAG GTPases in nutrient-mediated TOR signaling pathway
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28 November 2018
TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2.
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28 November 2018
Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits
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28 November 2018
PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.
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28 November 2018
mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes
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28 November 2018
Identifiers
DOI
10.1038/ONC.2010.139
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
840856
Dimensions Publication ID
1051644324
0 references
OpenCitations bibliographic resource ID
840856
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
840856
PMCID
3031870
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
840856
PubMed ID
20418915
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
840856
ResearchGate publication ID
43343256
0 references
Springer Nature article ID
10.1038/onc.2010.139
0 references
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