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Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling
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scholarly article
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title
Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling
(English)
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main subject
TNF
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author
Jun Ninomiya-Tsuji
series ordinal
3
object named as
Jun Ninomiya-Tsuji
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Richard Gaynor
series ordinal
5
object named as
Richard B Gaynor
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author name string
Tohru Ishitani
series ordinal
1
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Giichi Takaesu
series ordinal
2
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Hiroshi Shibuya
series ordinal
4
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Richard B Gaynor
series ordinal
5
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Kunihiro Matsumoto
series ordinal
6
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language of work or name
English
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publication date
1 December 2003
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published in
The EMBO Journal
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volume
22
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issue
23
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page(s)
6277-88
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cites work
Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291846
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7 April 2017
TAK1 is a ubiquitin-dependent kinase of MKK and IKK
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291846
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7 April 2017
Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291846
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7 April 2017
The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291846
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7 April 2017
TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291846
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7 April 2017
TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction
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PubMed Central
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7 April 2017
Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity
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PubMed Central
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7 April 2017
NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses
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PubMed Central
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PubMed Central
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7 April 2017
A ubiquitin-binding motif required for intramolecular monoubiquitylation, the CUE domain
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291846
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7 April 2017
TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291846
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7 April 2017
TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291846
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7 April 2017
NF-kappaB regulation in the immune system
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PubMed Central
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7 April 2017
Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kappaB-dependent innate immune responses
1 reference
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PubMed Central
reference URL
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7 April 2017
Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291846
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7 April 2017
TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291846
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7 April 2017
Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291846
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7 April 2017
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291846
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7 April 2017
TRAF6 is a signal transducer for interleukin-1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291846
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7 April 2017
Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291846
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7 April 2017
Missing pieces in the NF-kappaB puzzle
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291846
retrieved
7 April 2017
Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291846
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7 April 2017
Biologic basis for interleukin-1 in disease
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291846
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7 April 2017
Tumor necrosis factor (TNF)-induced germinal center kinase-related (GCKR) and stress-activated protein kinase (SAPK) activation depends upon the E2/E3 complex Ubc13-Uev1A/TNF receptor-associated factor 2 (TRAF2).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291846
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27 September 2017
TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291846
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27 September 2017
NF-kappaB signaling pathways in mammalian and insect innate immunity
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PubMed Central
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27 September 2017
Signal transduction by tumor necrosis factor and its relatives
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291846
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27 September 2017
Gene profiling during neural induction in Xenopus laevis: regulation of BMP signaling by post-transcriptional mechanisms and TAB3, a novel TAK1-binding protein.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291846
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28 November 2018
Smad5 induces ventral fates in Xenopus embryo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TGF beta signals through a heteromeric protein kinase receptor complex
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
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7 January 2021
based on heuristic
inferred from DOI database lookup
TGF-beta-receptor-mediated signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamily
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MADR1, a MAD-related protein that functions in BMP2 signaling pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The C-terminal domain of Mad-like signal transducers is sufficient for biological activity in the Xenopus embryo and transcriptional activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
SMADs: mediators and regulators of TGF-beta signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human Smad3 and Smad4 are sequence-specific transcription activators
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cell-free activation of a DNA-binding protein by epidermal growth factor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanism of activation of the TGF-beta receptor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TGF-beta signalling from cell membrane to nucleus through SMAD proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Smad4 and FAST-1 in the assembly of activin-responsive factor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A human Mad protein acting as a BMP-regulated transcriptional activator
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Receptor-associated Mad homologues synergize as effectors of the TGF-beta response
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A transcriptional partner for MAD proteins in TGF-beta signalling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Smad6 inhibits signalling by the TGF-beta superfamily
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A structural basis for mutational inactivation of the tumour suppressor Smad4
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DPC4 (SMAD4) mediates transforming growth factor-beta1 (TGF-beta1) induced growth inhibition and transcriptional response in breast tumour cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of transforming growth factor beta- and activin-induced transcription by mammalian Mad proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Smad8 mediates the signaling of the ALK-2 [corrected] receptor serine kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transforming Growth Factor β Activates the Promoter of Cyclin-dependent Kinase Inhibitor p15 through an Sp1 Consensus Site
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of functional domains within Smad4/DPC4
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transforming growth factor beta 1-responsive element: closely associated binding sites for USF and CCAAT-binding transcription factor-nuclear factor I in the type 1 plasminogen activator inhibitor gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The viral oncoprotein E1A blocks transforming growth factor beta-mediated induction of p21/WAF1/Cip1 and p15/INK4B.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Physiological actions and clinical applications of transforming growth factor-beta (TGF-beta).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG605
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1093/EMBOJ/CDG605
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PMC publication ID
291846
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PubMed publication ID
14633987
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ResearchGate publication ID
6738648
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