(Q24755824)

English

Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fluoropropyl)-4-methyl-pyridin-2-amine as a potential PET tracer for inducible nitric oxide synthase

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scholarly article

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Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fluoropropyl)-4-methyl-pyridin-2-amine as a potential PET tracer for inducible nitric oxide synthase (English)

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7

object named as

Robert H Mach

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author name string

Dong Zhou

1

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Hsiaoju Lee

2

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Justin M Rothfuss

3

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Delphine L Chen

4

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Datta E Ponde

5

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Michael J Welch

6

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language of work or name

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publication date

23 April 2009

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Journal of Medicinal Chemistry

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52

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8

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2443-53

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Nitric oxide synthases: structure, function and inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782628

7 April 2017

2-Amino-4-methylpyridine as a potent inhibitor of inducible NO synthase activity in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782628

7 April 2017

Nitric oxide as a secretory product of mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782628

7 April 2017

BYK191023 (2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3h-imidazo[4,5-b]pyridine) is an NADPH- and time-dependent irreversible inhibitor of inducible nitric-oxide synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782628

28 September 2017

The novel imidazopyridine 2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine (BYK191023) is a highly selective inhibitor of the inducible nitric-oxide synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782628

28 September 2017

Molecular pathophysiology of Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782628

28 September 2017

Modulation of prostaglandin biosynthesis by nitric oxide and nitric oxide donors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782628

28 September 2017

Inducible nitric oxide synthase (iNOS) in tumor biology: the two sides of the same coin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782628

28 September 2017

GW274150 and GW273629 are potent and highly selective inhibitors of inducible nitric oxide synthase in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782628

28 September 2017

Synthesis and evaluation of a fluorine-18 labeled antisense oligonucleotide as a potential PET tracer for iNOS mRNA expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782628

28 September 2017

Regulatory effects of iNOS on acute lung inflammatory responses in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782628

28 September 2017

The role of nitric oxide in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782628

28 September 2017

Blocking NO synthesis: how, where and why?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782628

28 September 2017

Nitric oxide in the pathogenesis of vascular disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782628

28 September 2017

Pharmacological modulation of nitric oxide synthesis by mechanism-based inactivators and related inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782628

28 September 2017

Inhibition of nitric oxide synthase as a potential therapeutic target

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782628

28 September 2017

Nitric oxide in septic shock

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782628

28 September 2017

Mammalian nitric oxide synthases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782628

28 September 2017

Synthesis and evaluation of two positron-labeled nitric oxide synthase inhibitors, S-[11C]methylisothiourea and S-(2-[18F]fluoroethyl)isothiourea, as potential positron emission tomography tracers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782628

28 September 2017

Nitric oxide synthase structure and mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782628

28 September 2017

Molecular mechanisms and therapeutic strategies related to nitric oxide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782628

28 September 2017

1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782628

30 May 2018

Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782628

30 May 2018

L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782628

30 May 2018

Importance of basal nitric oxide synthesis in regulation of myocardial blood flow.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782628

30 May 2018

Identification of N-iminoethyl-l-ornithine as an irreversible inhibitor of nitric oxide synthase in phagocytic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782628

30 May 2018

Effects of NG-nitro-L-arginine and L-arginine on regional cerebral blood flow in the cat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782628

30 May 2018

2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782628

28 November 2018

3,4-Dihydro-1-isoquinolinamines: a novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782628

28 November 2018

A potent inhibitor of inducible nitric oxide synthase, ONO-1714, a cyclic amidine derivative

1 reference

https://pubmed.ncbi.nlm.nih.gov/19323559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substituted 2-aminopyridines as inhibitors of nitric oxide synthases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19323559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analgesic activity of 2-amino-4-methylpyridine, a novel NO synthase inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19323559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catalysis by nitric oxide synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19323559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine

1 reference

https://pubmed.ncbi.nlm.nih.gov/19323559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lung, spleen, and kidney are the major places for inducible nitric oxide synthase expression in endotoxic shock: role of p38 mitogen-activated protein kinase in signal transduction of inducible nitric oxide synthase expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/19323559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of regional blood flow by endothelium-derived nitric oxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/19323559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potent and selective inhibition of human nitric oxide synthases. Selective inhibition of neuronal nitric oxide synthase by S-methyl-L-thiocitrulline and S-ethyl-L-thiocitrulline

1 reference

https://pubmed.ncbi.nlm.nih.gov/19323559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunochemical localization of inducible nitric oxide synthase in endotoxin-treated rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19323559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

S-alkyl-L-thiocitrullines. Potent stereoselective inhibitors of nitric oxide synthase with strong pressor activity in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/19323559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms

1 reference

https://pubmed.ncbi.nlm.nih.gov/19323559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential regulation of the constitutive and inducible nitric oxide synthase mRNA by lipopolysacchride treatment in vivo in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/19323559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM801556H

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