(Q35013972)

5 August 2017

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title

Blocking NO synthesis: how, where and why? (English)

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5 August 2017

1

Patrick Vallance

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5 August 2017

James Leiper

2

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5 August 2017

publication date

1 December 2002

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Nature Reviews Drug Discovery

5 August 2017

published in

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5 August 2017

volume

1

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5 August 2017

issue

12

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5 August 2017

page(s)

939-950

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Nitric oxide donors and cardiovascular agents modulating the bioactivity of nitric oxide: an overview

5 August 2017

cites work

1 reference

Nitric oxide synthases: structure, function and inhibition

31 March 2020

1 reference

Enhanced electron flux and reduced calmodulin dissociation may explain "calcium-independent" eNOS activation by phosphorylation

31 March 2020

1 reference

Purification and assessment of proteins associated with nitric oxide synthase

31 March 2020

1 reference

Nitric oxide as a signaling molecule in the vascular system: an overview.

31 March 2020

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Novel effects of nitric oxide

31 March 2020

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Nitric oxide chemistry and cellular signaling

31 March 2020

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[47] Nitration of unsaturated fatty acids by nitric oxide-derived reactive species

31 March 2020

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Nitrosylation. the prototypic redox-based signaling mechanism.

31 March 2020

1 reference

Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase

31 March 2020

1 reference

Nitric oxide and atherosclerosis

31 March 2020

1 reference

Chronic inhibition of nitric oxide production accelerates neointima formation and impairs endothelial function in hypercholesterolemic rabbits

31 March 2020

1 reference

Accelerated atherosclerosis, aortic aneurysm formation, and ischemic heart disease in apolipoprotein E/endothelial nitric oxide synthase double-knockout mice

31 March 2020

1 reference

Nitrergic transmission: nitric oxide as a mediator of non-adrenergic, non-cholinergic neuro-effector transmission

31 March 2020

1 reference

Neural roles for heme oxygenase: contrasts to nitric oxide synthase

31 March 2020

1 reference

Urinary bladder-urethral sphincter dysfunction in mice with targeted disruption of neuronal nitric oxide synthase models idiopathic voiding disorders in humans

31 March 2020

1 reference

Nitric oxide in skeletal muscle

31 March 2020

1 reference

Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy

31 March 2020

1 reference

Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms

31 March 2020

1 reference

Contribution of nitric oxide synthases 1, 2, and 3 to airway hyperresponsiveness and inflammation in a murine model of asthma

31 March 2020

1 reference

Interaction of genetic deficiency of endothelial nitric oxide, gender, and pregnancy in vascular response to injury in mice

31 March 2020

1 reference

Nitric oxide: a cytotoxic activated macrophage effector molecule

31 March 2020

1 reference

Nitric oxide synthase: Aspects concerning structure and catalysis

31 March 2020

1 reference

Nitric oxide and the immune response

31 March 2020

1 reference

Effects of nitric oxide on the induction and differentiation of Th1 cells

31 March 2020

1 reference

Requirement of the inducible nitric oxide synthase pathway for IL-1-induced osteoclastic bone resorption

31 March 2020

1 reference

The protective role of nitric oxide in a neurotoxicant-induced demyelinating model

31 March 2020

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Inducible nitric oxide synthase (iNOS) activity promotes ischaemic skin flap survival

31 March 2020

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The role of nitric oxide in nociception

31 March 2020

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Gene expression profiling of mouse bladder inflammatory responses to LPS, substance P, and antigen-stimulation

31 March 2020

1 reference

31 March 2020

Nitric oxide and bone

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Nitric oxide and intestinal inflammation

31 March 2020

1 reference

Nitric oxide in asthma. Pathogenic, therapeutic, or diagnostic?

31 March 2020

1 reference

Endogenous nitric oxide in allergic airway disease

31 March 2020

1 reference

Involvement of inducible nitric oxide synthase in inflammation-induced dopaminergic neurodegeneration

31 March 2020

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Expression and function of inducible nitric oxide synthase in neurons

31 March 2020

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Nitric oxide inhibitors attenuate N-methyl-D-aspartate excitotoxicity in rat hippocampal slices

31 March 2020

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Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase

31 March 2020

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Nitric oxide is proangiogenic in the retina and choroid.

31 March 2020

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Cytokine-induced venodilatation in humans in vivo: eNOS masquerading as iNOS.

31 March 2020

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Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69.

31 March 2020

1 reference

Does nitric oxide modulate mitochondrial energy generation and apoptosis?

31 March 2020

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Role of nitric oxide in carcinogenesis and tumour progression

31 March 2020

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Role of nitric oxide in myocardial preconditioning

31 March 2020

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Regulation of caspases by nitric oxide

31 March 2020

1 reference

Inducible nitric oxide synthase: a little bit of good in all of us

31 March 2020

1 reference

The Use of Aminoguanidine, a Selective iNOS Inhibitor, to Evaluate the Role of Nitric Oxide in the Development of Autoimmune Diabetes

31 March 2020

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Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans

31 March 2020

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Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock

31 March 2020

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Effects of a nitric oxide synthase inhibitor in humans with septic shock

31 March 2020

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Effect of inhibition of nitric oxide synthase on chronic tension-type headache: a randomised crossover trial

31 March 2020

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Nitric oxide and human skin blood flow responses to acetylcholine and ultraviolet light.

31 March 2020

1 reference

Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo

31 March 2020

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Implications for isoform-selective inhibitor design derived from the binding mode of bulky isothioureas to the heme domain of endothelial nitric-oxide synthase

31 March 2020

1 reference

Crystal structures of zinc-free and -bound heme domain of human inducible nitric-oxide synthase. Implications for dimer stability and comparison with endothelial nitric-oxide synthase

31 March 2020

1 reference

1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo

31 March 2020

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Interactive roles of superoxide and inducible nitric oxide synthase in rat intestinal injury provoked by non-steroidal anti-inflammatory drugs

31 March 2020

1 reference

3,4-Dihydro-1-isoquinolinamines: a novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency

31 March 2020

1 reference

L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase.

31 March 2020

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Synthesis and biological characterization of L-N(6)-(1-iminoethyl)lysine 5-tetrazole-amide, a prodrug of a selective iNOS inhibitor

31 March 2020

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Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry

31 March 2020

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Mechanistic studies with potent and selective inducible nitric-oxide synthase dimerization inhibitors

31 March 2020

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Functional effects of econazole on inducible nitric oxide synthase: production of a calmodulin-dependent enzyme

31 March 2020

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Structural requirements for inhibition of the neuronal nitric oxide synthase (NOS-I): 3D-QSAR analysis of 4-oxo- and 4-amino-pteridine-based inhibitors

31 March 2020

1 reference

PIN: an associated protein inhibitor of neuronal nitric oxide synthase

31 March 2020

1 reference

ARL 17477, a selective nitric oxide synthase inhibitor, with neuroprotective effects in animal models of global and focal cerebral ischaemia

31 March 2020

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N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase

31 March 2020

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Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells

31 March 2020

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Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure

31 March 2020

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Biological significance of endogenous methylarginines that inhibit nitric oxide synthases

31 March 2020

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Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases

31 March 2020

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Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolase

31 March 2020

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Dimethylarginine dimethylaminohydrolase (DDAH) as a nerve-injury-associated molecule: mRNA localization in the rat brain and its coincident up-regulation with neuronal NO synthase (nNOS) in axotomized motoneurons

31 March 2020

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Reduction in asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in the cerebrospinal fluid during aging and in patients with Alzheimer's disease

31 March 2020

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Structural insights into the hydrolysis of cellular nitric oxide synthase inhibitors by dimethylarginine dimethylaminohydrolase

31 March 2020

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The preferred source of arginine for high-output nitric oxide synthesis in blood vessels

31 March 2020

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S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase

31 March 2020

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Aconitases: a class of metalloproteins highly sensitive to nitric oxide synthesis

31 March 2020

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Cysteine-3635 is responsible for skeletal muscle ryanodine receptor modulation by NO

31 March 2020

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Differential sensitivity of the tyrosyl radical of mouse ribonucleotide reductase to nitric oxide and peroxynitrite

31 March 2020

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Nitric oxide trapping of tyrosyl radicals generated during prostaglandin endoperoxide synthase turnover. Detection of the radical derivative of tyrosine 385

31 March 2020

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Hypertension in mice lacking the gene for endothelial nitric oxide synthase

31 March 2020

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Enlarged infarcts in endothelial nitric oxide synthase knockout mice are attenuated by nitro-L-arginine

31 March 2020

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Temporal correlation mapping analysis of the hemodynamic penumbra in mutant mice deficient in endothelial nitric oxide synthase gene expression.

31 March 2020

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Effects of nitric oxide synthase gene knockout on neurotransmitter release in vivo

31 March 2020

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Attenuated hippocampal damage after global cerebral ischemia in mice mutant in neuronal nitric oxide synthase

31 March 2020

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Cholinergic contraction is altered in nNOS knockouts. Cooperative modulation of neural bronchoconstriction by nNOS and COX.

31 March 2020

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Targeted disruption of the neuronal nitric oxide synthase gene.

31 March 2020

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Neuronal constitutive nitric oxide synthase is involved in murine enteric inhibitory neurotransmission

31 March 2020

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Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase

31 March 2020

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Altered immune responses in mice lacking inducible nitric oxide synthase

31 March 2020

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NO in septic shock: good, bad or ugly? Learning from iNOS knockouts.

31 March 2020

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Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the Apc(Min/+) mouse

31 March 2020

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Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer

31 March 2020

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Neuronal and glial coexpression of argininosuccinate synthetase and inducible nitric oxide synthase in Alzheimer disease

31 March 2020

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Expression of inducible nitric oxide synthase and Fas/Fas ligand correlates with the incidence of apoptotic cell death in atheromatous plaques of human coronary arteries

31 March 2020

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Histochemical evidence for inducible nitric oxide synthase in advanced but non-ruptured human atherosclerotic carotid arteries

31 March 2020

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Increased activity and expression of iNOS in human duodenal enterocytes from patients with celiac disease

31 March 2020

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Increased expression of inducible nitric oxide synthase in circulating monocytes from patients with active inflammatory bowel disease

31 March 2020

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Expression of nitric oxide synthases and effects of L-arginine and L-NMMA on nitric oxide production and fluid transport in collagenous colitis

31 March 2020

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Expression of inducible nitric oxide synthase and nitrotyrosine in multiple sclerosis lesions

31 March 2020

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Regulation of the nitric oxide production resulting from the glucocorticoid-insensitive expression of iNOS in human osteoarthritic cartilage

31 March 2020

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Inflammatory regulators in Parkinson's disease: iNOS, lipocortin-1, and cyclooxygenases-1 and -2.

31 March 2020

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Compartmentalised inducible nitric-oxide synthase activity in septic shock.

31 March 2020

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Inducible nitric oxide synthase expression in human cerebral infarcts

31 March 2020

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Long-term treatment with N(omega)-nitro-L-arginine methyl ester causes arteriosclerotic coronary lesions in endothelial nitric oxide synthase-deficient mice.

31 March 2020

1 reference

Nitric oxide in neurodegeneration

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Synthesis and evaluation of peptidomimetics as selective inhibitors and active site probes of nitric oxide synthases

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD960

1 reference

release_4wc7gabxorgqbeae27dzx2zefy

5 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/4wc7gabxorgqbeae27dzx2zefy

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference