(Q24793070)

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Does protein kinase R mediate TNF-alpha- and ceramide-induced increases in expression and activation of matrix metalloproteinases in articular cartilage by a novel mechanism?

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Does protein kinase R mediate TNF-alpha- and ceramide-induced increases in expression and activation of matrix metalloproteinases in articular cartilage by a novel mechanism? (English)

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1 reference

based on heuristic

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1 reference

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author name string

Sophie J Gilbert

1

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Victor C Duance

2

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Deborah J Mason

3

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publication date

2004

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Arthritis Research and Therapy

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6

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1

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R46-R55

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PACT, a protein activator of the interferon-induced protein kinase, PKR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400415

7 April 2017

Interleukin 3 stimulates protein synthesis by regulating double-stranded RNA-dependent protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400415

7 April 2017

Intracellular signal transduction pathways activated by ceramide and its metabolites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400415

28 September 2017

Tumour necrosis factor alpha up-regulates protein kinase R (PKR)-activating protein (PACT) and increases phosphorylation of PKR and eukaryotic initiation factor 2-alpha in articular chondrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400415

28 September 2017

Apoptosis and cellular vitality: issues in osteoarthritic cartilage degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400415

28 September 2017

Signal integration via PKR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400415

28 September 2017

Up-regulation of matrix metalloproteinase expression and activation following cyclical compressive loading of articular cartilage in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400415

28 September 2017

Osteoarthritis and cartilage: the role of cytokines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400415

28 September 2017

Inhibition of caspase-3-like activity prevents apoptosis while retaining functionality of human chondrocytes in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400415

28 September 2017

Anabolic and destructive mediators in osteoarthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400415

28 September 2017

Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400415

28 September 2017

NF-kappaB activation by double-stranded-RNA-activated protein kinase (PKR) is mediated through NF-kappaB-inducing kinase and IkappaB kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400415

28 September 2017

The role of cytokines in the pathogenesis of rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400415

28 September 2017

JNK2 and IKKbeta are required for activating the innate response to viral infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400415

28 September 2017

n-3 fatty acids specifically modulate catabolic factors involved in articular cartilage degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400415

28 September 2017

A cis-acting element in the 3'-untranslated region of human TNF-alpha mRNA renders splicing dependent on the activation of protein kinase PKR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400415

28 September 2017

Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400415

28 September 2017

A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400415

28 September 2017

An essential role for the interferon-inducible, double-stranded RNA-activated protein kinase PKR in the tumor necrosis factor-induced apoptosis in U937 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400415

28 September 2017

Lipid mediator networks in cell signaling: update and impact of cytokines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400415

28 September 2017

Evidence for metalloproteinase and metalloproteinase inhibitor imbalance in human osteoarthritic cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400415

28 September 2017

Synovial fluid concentration of five different cytokines in rheumatic diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400415

28 September 2017

Transcriptional control of matrix metalloproteinases and the tissue inhibitors of matrix metalloproteinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400415

28 September 2017

Platelet-derived growth factor signal transduction through the interferon-inducible kinase PKR. Immediate early gene induction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400415

28 September 2017

PACT, a stress-modulated cellular activator of interferon-induced double-stranded RNA-activated protein kinase, PKR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400415

30 May 2018

Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoarthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400415

30 May 2018

Phosphorylation of eukaryotic translation initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNA-dependent protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400415

30 May 2018

The double-stranded RNA-dependent protein kinase PKR: structure and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400415

30 May 2018

Inhibition of furin-like enzymes blocks interleukin-1alpha/oncostatin M-stimulated cartilage degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400415

28 November 2018

Apoptosis of human hepatic myofibroblasts promotes activation of matrix metalloproteinase-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400415

28 November 2018

Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400415

28 November 2018

Effects of ceramide on aggrecanase activity in rabbit articular cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400415

28 November 2018

Ceramide regulates protein synthesis by a novel mechanism involving the cellular PKR activator RAX.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400415

28 November 2018

Characterization of the solution complex between the interferon-induced, double-stranded RNA-activated protein kinase and HIV-I trans-activating region RNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=400415

28 November 2018

Induction of apoptosis in chondrocytes by tumor necrosis factor-alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/14979937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preconditioning decreases ischemia/reperfusion-induced release and activation of matrix metalloproteinase-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/14979937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancement of fibroblast collagenase (matrix metalloproteinase-1) gene expression by ceramide is mediated by extracellular signal-regulated and stress-activated protein kinase pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/14979937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of Double-stranded RNA-activated Protein Kinase in the Synergistic Activation of Nuclear Factor-κB by Tumor Necrosis Factor-α and γ-Interferon in Preneuronal Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/14979937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor alpha can contribute to focal loss of cartilage in osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/14979937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of ceramide on apoptosis, proteoglycan degradation, and matrix metalloproteinase expression in rabbit articular cartilage

1 reference

https://pubmed.ncbi.nlm.nih.gov/14979937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of the 92-kDa gelatinase (matrix metalloproteinase-9) in the ceramide-mediated inhibition of human keratinocyte growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/14979937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anabolic and catabolic gene expression pattern analysis in normal versus osteoarthritic cartilage using complementary DNA-array technology

1 reference

https://pubmed.ncbi.nlm.nih.gov/14979937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated levels of proteolytic enzymes in the aging human vitreous

1 reference

https://pubmed.ncbi.nlm.nih.gov/14979937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3

1 reference

https://pubmed.ncbi.nlm.nih.gov/14979937

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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