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Antiviral therapies on the horizon for influenza
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
27570127
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27570127%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
review article
1 reference
stated in
Europe PubMed Central
title
Antiviral therapies on the horizon for influenza
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
27570127
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27570127%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
author
Lieve Naesens
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
27570127
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27570127%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
Annelies Stevaert
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
27570127
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27570127%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
Evelien Vanderlinden
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed ID
27570127
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27570127%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
author name string
Annelies Stevaert
series ordinal
2
0 references
Evelien Vanderlinden
series ordinal
3
0 references
publication date
26 August 2016
1 reference
stated in
Europe PubMed Central
PubMed ID
27570127
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27570127%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
published in
Current Opinion in Pharmacology
2 references
stated in
PubMed
stated in
Europe PubMed Central
PubMed ID
27570127
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27570127%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
volume
30
1 reference
stated in
Europe PubMed Central
PubMed ID
27570127
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27570127%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
page(s)
106-115
1 reference
stated in
Europe PubMed Central
PubMed ID
27570127
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27570127%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
cites work
Recent progress in designing inhibitors that target the drug-resistant M2 proton channels from the influenza A viruses.
1 reference
stated in
Crossref
reference URL
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Emerging antiviral strategies to interfere with influenza virus entry
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stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
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7 January 2021
based on heuristic
inferred from DOI database lookup
The Influenza Virus Polymerase Complex: An Update on Its Structure, Functions, and Significance for Antiviral Drug Design
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
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7 January 2021
based on heuristic
inferred from DOI database lookup
PA subunit of RNA polymerase as a promising target for anti-influenza virus agents
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
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7 January 2021
based on heuristic
inferred from DOI database lookup
Favipiravir (T-705), a novel viral RNA polymerase inhibitor
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
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7 January 2021
based on heuristic
inferred from DOI database lookup
Nitazoxanide: a first-in-class broad-spectrum antiviral agent
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
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inferred from DOI database lookup
Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2013-2014.
1 reference
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inferred from DOI database lookup
Identification of a small-molecule inhibitor of influenza virus via disrupting the subunits interaction of the viral polymerase
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Meeting report: 4th ISIRV antiviral group conference: Novel antiviral therapies for influenza and other respiratory viruses.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
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7 January 2021
based on heuristic
inferred from DOI database lookup
Peptide entry inhibitors of enveloped viruses: the importance of interfacial hydrophobicity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
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7 January 2021
based on heuristic
inferred from DOI database lookup
Broadly neutralizing influenza hemagglutinin stem-specific antibody CR8020 targets residues that are prone to escape due to host selection pressure
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
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7 January 2021
based on heuristic
inferred from DOI database lookup
Neuraminidase inhibitors: who, when, where?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
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7 January 2021
based on heuristic
inferred from DOI database lookup
Influenza virus-host interactomes as a basis for antiviral drug development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
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7 January 2021
based on heuristic
inferred from DOI database lookup
Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
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7 January 2021
based on heuristic
inferred from DOI database lookup
Emerging antiviral targets for influenza A virus.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
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7 January 2021
based on heuristic
inferred from DOI database lookup
Oseltamivir treatment for influenza in adults: a meta-analysis of randomised controlled trials
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
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7 January 2021
based on heuristic
inferred from DOI database lookup
Estimated global mortality associated with the first 12 months of 2009 pandemic influenza A H1N1 virus circulation: a modelling study
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
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7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of nitazoxanide in adults and adolescents with acute uncomplicated influenza: a double-blind, randomised, placebo-controlled, phase 2b/3 trial
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
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7 January 2021
based on heuristic
inferred from DOI database lookup
Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
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7 January 2021
based on heuristic
inferred from DOI database lookup
A Broad Anti-influenza Hybrid Small Molecule That Potently Disrupts the Interaction of Polymerase Acidic Protein-Basic Protein 1 (PA-PB1) Subunits
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
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7 January 2021
based on heuristic
inferred from DOI database lookup
Crystallographic Fragment Screening and Structure-Based Optimization Yields a New Class of Influenza Endonuclease Inhibitors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
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7 January 2021
based on heuristic
inferred from DOI database lookup
Discovery of novel dual inhibitors of the wild-type and the most prevalent drug-resistant mutant, S31N, of the M2 proton channel from influenza A virus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
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7 January 2021
based on heuristic
inferred from DOI database lookup
Discovery of a novel, first-in-class, orally bioavailable azaindole inhibitor (VX-787) of influenza PB2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
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7 January 2021
based on heuristic
inferred from DOI database lookup
Crystal structure of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
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7 January 2021
based on heuristic
inferred from DOI database lookup
The structural basis for an essential subunit interaction in influenza virus RNA polymerase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
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7 January 2021
based on heuristic
inferred from DOI database lookup
Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
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7 January 2021
based on heuristic
inferred from DOI database lookup
The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
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7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of influenza A polymerase bound to the viral RNA promoter
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
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7 January 2021
based on heuristic
inferred from DOI database lookup
Structural insight into cap-snatching and RNA synthesis by influenza polymerase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Crystal structure of the RNA-dependent RNA polymerase from influenza C virus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of influenza A nucleoprotein as an antiviral target
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
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7 January 2021
based on heuristic
inferred from DOI database lookup
Generation and characterization of influenza A viruses with altered polymerase fidelity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
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7 January 2021
based on heuristic
inferred from DOI database lookup
Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
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7 January 2021
based on heuristic
inferred from DOI database lookup
The structural basis for cap binding by influenza virus polymerase subunit PB2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Using mutagenesis to explore conserved residues in the RNA-binding groove of influenza A virus nucleoprotein for antiviral drug development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of influenza hemagglutinin in complex with an inhibitor of membrane fusion
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
High-throughput identification of compounds targeting influenza RNA-dependent RNA polymerase activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Small molecule inhibitors of influenza A and B viruses that act by disrupting subunit interactions of the viral polymerase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A broadly neutralizing human monoclonal antibody is effective against H7N9.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The crystal structure of the PB2 cap-binding domain of influenza B virus reveals a novel cap recognition mechanism.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular Basis of mRNA Cap Recognition by Influenza B Polymerase PB2 Subunit.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Preclinical pharmacokinetics of MHAA4549A, a human monoclonal antibody to influenza A virus, and the prediction of its efficacious clinical dose for the treatment of patients hospitalized with influenza A.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A phase II study of DAS181, a novel host directed antiviral for the treatment of influenza infection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of human hypoxanthine guanine phosphoribosyltransferase in activation of the antiviral agent T-705 (favipiravir)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Highly Conserved Protective Epitopes on Influenza B Viruses
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanism of action of T-705 ribosyl triphosphate against influenza virus RNA polymerase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure-based discovery of the novel antiviral properties of naproxen against the nucleoprotein of influenza A virus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Preclinical activity of VX-787, a first-in-class, orally bioavailable inhibitor of the influenza virus polymerase PB2 subunit
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of cap (m7GpppXm)-dependent endonuclease of influenza virus by 4-substituted 2,4-dioxobutanoic acid compounds
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanism of action of T-705 against influenza virus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutational analysis of the binding pockets of the diketo acid inhibitor L-742,001 in the influenza virus PA endonuclease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
T-705 (favipiravir) induces lethal mutagenesis in influenza A H1N1 viruses in vitro
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Recognition of cap structure by influenza B virus RNA polymerase is less dependent on the methyl residue than recognition by influenza A virus polymerase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Broadly neutralizing antiviral antibodies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Broadly neutralizing anti-influenza antibodies require Fc receptor engagement for in vivo protection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The ambiguous base-pairing and high substrate efficiency of T-705 (Favipiravir) Ribofuranosyl 5'-triphosphate towards influenza A virus polymerase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A novel small molecule inhibitor of influenza A viruses that targets polymerase function and indirectly induces interferon
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza pH1N1 (2009) Polymerase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A Novel Antiviral Target Structure Involved in the RNA Binding, Dimerization, and Nuclear Export Functions of the Influenza A Virus Nucleoprotein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.COPH.2016.08.003
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/J.COPH.2016.08.003
1 reference
stated in
Europe PubMed Central
PubMed ID
27570127
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27570127%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
PubMed ID
27570127
1 reference
stated in
Europe PubMed Central
PubMed ID
27570127
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27570127%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
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