(Q26766713)

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Engineered hapten-binding antibody derivatives for modulation of pharmacokinetic properties of small molecules and targeted payload delivery

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scholarly article

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9 references

25 June 2019

19 September 2019

27 November 2019

13 December 2019

1 June 2020

26 October 2020

13 November 2020

25 January 2021

20 October 2022

Engineered hapten-binding antibody derivatives for modulation of pharmacokinetic properties of small molecules and targeted payload delivery (English)

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biomedical investigative technique

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19 September 2019

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27 November 2019

1 reference

13 December 2019

pharmacokinetics

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based on heuristic

inferred from title

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based on heuristic

inferred from title

drug delivery system

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26 October 2020

targeted therapy

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13 November 2020

bispecific antibodies

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25 January 2021

author name string

Stefan Dengl

1

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Claudio Sustmann

2

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Ulrich Brinkmann

3

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language of work or name

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publication date

March 2016

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1 March 2016

9 references

25 June 2019

19 September 2019

27 November 2019

13 December 2019

1 June 2020

26 October 2020

13 November 2020

25 January 2021

20 October 2022

Immunological Reviews

9 references

25 June 2019

19 September 2019

27 November 2019

13 December 2019

1 June 2020

26 October 2020

13 November 2020

25 January 2021

20 October 2022

270

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165-77

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1

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copyright license

Creative Commons Attribution-NonCommercial-NoDerivatives

9 references

25 June 2019

19 September 2019

27 November 2019

13 December 2019

1 June 2020

26 October 2020

13 November 2020

25 January 2021

20 October 2022

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

7 April 2017

The Protein Data Bank

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

7 April 2017

Assembly of combinatorial antibody libraries on phage surfaces: the gene III site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

7 April 2017

Humanization of an anti-p185HER2 antibody for human cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

7 April 2017

Bispecific antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

7 April 2017

Bispecific digoxigenin-binding antibodies for targeted payload delivery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

7 April 2017

A pretargeting system for tumor PET imaging and radioimmunotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

7 April 2017

HaptenDB: a comprehensive database of haptens, carrier proteins and anti-hapten antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

7 April 2017

Selective Delivery of PEGylated Compounds to Tumor Cells by Anti-PEG Hybrid Antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

Hapten-directed spontaneous disulfide shuffling: a universal technology for site-directed covalent coupling of payloads to antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

Tumor-antigen-binding bispecific antibodies for cancer treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

One-step mixing with humanized anti-mPEG bispecific antibody enhances tumor accumulation and therapeutic efficacy of mPEGylated nanoparticles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

Zirconium-89 labeled antibodies: a new tool for molecular imaging in cancer patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

A novel glycoengineered bispecific antibody format for targeted inhibition of epidermal growth factor receptor (EGFR) and insulin-like growth factor receptor type I (IGF-1R) demonstrating unique molecular properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

Site-specific antibody drug conjugates for cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

Quantification of cell surface proteins with bispecific antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

The intriguing options of multispecific antibody formats for treatment of cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

Bispecific antibody derivatives with restricted binding functionalities that are activated by proteolytic processing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

Progress in overcoming the chain association issue in bispecific heterodimeric IgG antibodies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

Pretargeted molecular imaging and radioimmunotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

Development of tetravalent IgG1 dual targeting IGF-1R-EGFR antibodies with potent tumor inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

Generation of dual-variable-domain immunoglobulin molecules for dual-specific targeting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

State of the art in PEGylation: the great versatility achieved after forty years of research

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

Translational studies on PYY as a novel target in obesity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

Strategies for extended serum half-life of protein therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

Development of tetravalent, bispecific CCR5 antibodies with antiviral activity against CCR5 monoclonal antibody-resistant HIV-1 strains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

Chemical generation of bispecific antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

Fluorescent Citrine-IgG fusion proteins produced in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

Affinity maturation by phage display

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

FcRn: the neonatal Fc receptor comes of age.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

A bivalent disulfide-stabilized Fv with improved antigen binding to erbB2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

An efficient route to human bispecific IgG.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

Disulfide stabilization of antibody Fv: computer predictions and experimental evaluation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

The digoxigenin (DIG) system for non-radioactive labelling and detection of nucleic acids--an overview.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

A recombinant immunotoxin containing a disulfide-stabilized Fv fragment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

Stabilization of the Fv fragments in recombinant immunotoxins by disulfide bonds engineered into conserved framework regions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

Phage display of disulfide-stabilized Fv fragments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

Preparation and characterization of a disulfide-stabilized Fv fragment of the anti-Tac antibody: comparison with its single-chain analog

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

Human antibody libraries in Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

The Three-Dimensional Structure of a Phosphorylcholine-Binding Mouse Immunoglobulin Fab and the Nature of the Antigen Binding Site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

The three dimensional structure of a combining region-ligand complex of immunoglobulin NEW at 3.5-A resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

Three-dimensional structure of the Fab' fragment of a human immunoglobulin at 2,8-A resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

The digoxigenin:anti-digoxigenin (DIG) technology--a survey on the concept and realization of a novel bioanalytical indicator system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

1 Modeling of antibody combining sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

Antibody engineering

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

Structural implications of sequence variability in immunoglobulins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

Proceedings: The structural basis of antibody specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

Plasma half-life extension of small recombinant antibodies by fusion to immunoglobulin-binding domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

Assembly of a functional immunoglobulin Fv fragment in Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 September 2017

Targeted siRNA Delivery and mRNA Knockdown Mediated by Bispecific Digoxigenin-binding Antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

31 May 2018

Improved binding and antitumor activity of a recombinant anti-erbB2 immunotoxin by disulfide stabilization of the Fv fragment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

31 May 2018

The disulfide bonds in antibody variable domains: effects on stability, folding in vitro, and functional expression in Escherichia coli.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

19 June 2018

Design and production of novel tetravalent bispecific antibodies

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12386

21 January 2018

Engineering interchain disulfide bonds into conserved framework regions of Fv fragments: improved biochemical characteristics of recombinant immunotoxins containing disulfide-stabilized Fv.

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12386

21 January 2018

Engineering antibody Fv fragments for cancer detection and therapy: disulfide-stabilized Fv fragments.

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12386

21 January 2018

Molecular construction and optimization of anti-human IL-1alpha/beta dual variable domain immunoglobulin (DVD-Ig) molecules

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12386

21 January 2018

Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin.

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12386

21 January 2018

Hydroxyethyl starch for intravenous volume replacement: more harm than benefit

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12386

21 January 2018

Chemically programmed antibodies: endothelin receptor targeting CovX-Bodies.

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12386

21 January 2018

PK modulation of haptenylated peptides via non-covalent antibody complexation

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12386

21 January 2018

Pretargeted radioimmunoscintigraphy in patients with primary colorectal cancer using a bispecific anticarcinoembryonic antigen CEA X anti-di-diethylenetriaminepentaacetic acid F(ab')2 antibody

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12386

21 January 2018

Development of a humanized disulfide-stabilized anti-p185HER2 Fv-beta-lactamase fusion protein for activation of a cephalosporin doxorubicin prodrug.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755198

28 November 2018

'Knobs-into-holes' engineering of antibody CH3 domains for heavy chain heterodimerization

1 reference

https://pubmed.ncbi.nlm.nih.gov/26864111

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bispecific antibody derivatives based on full-length IgG formats

1 reference

https://pubmed.ncbi.nlm.nih.gov/26864111

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hapten-Binding Bispecific Antibodies for the Targeted Delivery of SiRNA and SiRNA-Containing Nanoparticles

1 reference

https://pubmed.ncbi.nlm.nih.gov/26864111

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Performance of calibration standards for antigen quantitation with flow cytometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/26864111

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formalization of the MESF unit of fluorescence intensity

1 reference

https://pubmed.ncbi.nlm.nih.gov/26864111

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor activity and pharmacokinetics in mice of a recombinant immunotoxin containing a disulfide-stabilized Fv fragment

1 reference

https://pubmed.ncbi.nlm.nih.gov/26864111

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single-chain antigen-binding proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/26864111

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytotoxic and antitumor activity of a recombinant immunotoxin composed of disulfide-stabilized anti-Tac Fv fragment and truncated Pseudomonas exotoxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/26864111

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure at 4.5 Å; Resolution of a Phosphorylcholine-binding Fab

1 reference

https://pubmed.ncbi.nlm.nih.gov/26864111

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/IMR.12386

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