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Metazoan Hsp70-based protein disaggregases: emergence and mechanisms
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Europe PubMed Central
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4598581
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28 February 2020
title
Metazoan Hsp70-based protein disaggregases: emergence and mechanisms
(English)
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4598581
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28 February 2020
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Nadinath B Nillegoda
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1
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Europe PubMed Central
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4598581
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28 February 2020
Bernd Bukau
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2
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4598581
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28 February 2020
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Nadinath B Nillegoda
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English
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publication date
9 October 2015
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4598581
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28 February 2020
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Frontiers in molecular biosciences
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4598581
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28 February 2020
volume
2
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4598581
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28 February 2020
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57
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4598581
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28 February 2020
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28 September 2017
Cellular strategies for controlling protein aggregation
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Multiple molecules of Hsc70 and a dimer of DjA1 independently bind to an unfolded protein
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Molecular chaperones antagonize proteotoxicity by differentially modulating protein aggregation pathways
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28 September 2017
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28 September 2017
Insights into the structural dynamics of the Hsp110-Hsp70 interaction reveal the mechanism for nucleotide exchange activity
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 September 2017
Collaboration between the ClpB AAA+ remodeling protein and the DnaK chaperone system
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 September 2017
Heat-shock protein 105 interacts with and suppresses aggregation of mutant Cu/Zn superoxide dismutase: clues to a possible strategy for treating ALS.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 September 2017
Keep the traffic moving: mechanism of the Hsp70 motor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 September 2017
Hsp70 chaperones accelerate protein translocation and the unfolding of stable protein aggregates by entropic pulling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 September 2017
Thermotolerance requires refolding of aggregated proteins by substrate translocation through the central pore of ClpB.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 September 2017
Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 September 2017
Hsp105alpha suppresses the aggregation of truncated androgen receptor with expanded CAG repeats and cell toxicity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 September 2017
Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 September 2017
The djlA gene acts synergistically with dnaJ in promoting Escherichia coli growth.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 September 2017
The hsp110 and Grp1 70 stress proteins: newly recognized relatives of the Hsp70s
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 September 2017
Mutants of Arabidopsis thaliana defective in the acquisition of tolerance to high temperature stress
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 September 2017
Sequential mechanism of solubilization and refolding of stable protein aggregates by a bichaperone network
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 September 2017
Heat-inactivated proteins are rescued by the DnaK.J-GrpE set and ClpB chaperones
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 September 2017
Mechanism of regulation of hsp70 chaperones by DnaJ cochaperones
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 September 2017
Structure, function and evolution of DnaJ: conservation and adaptation of chaperone function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 September 2017
Leishmania major Hsp100 is required chiefly in the mammalian stage of the parasite
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 September 2017
A novel hsp110-related gene, apg-1, that is abundantly expressed in the testis responds to a low temperature heat shock rather than the traditional elevated temperatures
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 September 2017
A conserved HPD sequence of the J-domain is necessary for YDJ1 stimulation of Hsp70 ATPase activity at a site distinct from substrate binding
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 September 2017
Cloning and expression of murine high molecular mass heat shock proteins, HSP105.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 September 2017
Glutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 September 2017
ClpB is the Escherichia coli heat shock protein F84.1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 September 2017
Surface adsorption considerations when working with amyloid fibrils in multiwell plates and Eppendorf tubes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
31 May 2018
Hsp70 targets Hsp100 chaperones to substrates for protein disaggregation and prion fragmentation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
31 May 2018
Unique peptide substrate binding properties of 110-kDa heat-shock protein (Hsp110) determine its distinct chaperone activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
31 May 2018
Identification of thermolabile Escherichia coli proteins: prevention and reversion of aggregation by DnaK and ClpB.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
31 May 2018
Structural features required for the interaction of the Hsp70 molecular chaperone DnaK with its cochaperone DnaJ.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
31 May 2018
Hsp110 protects heat-denatured proteins and confers cellular thermoresistance.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
31 May 2018
Thermotolerance in mammalian cells. Protein denaturation and aggregation, and stress proteins.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
31 May 2018
Physical interaction between heat shock proteins DnaK, DnaJ, and GrpE and the bacterial heat shock transcription factor sigma 32
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
31 May 2018
Unraveling the mechanism of protein disaggregation through a ClpB-DnaK interaction.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 November 2018
Disruption of ionic interactions between the nucleotide binding domain 1 (NBD1) and middle (M) domain in Hsp100 disaggregase unleashes toxic hyperactivity and partial independence from Hsp70.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 November 2018
Hsp70 proteins bind Hsp100 regulatory M domains to activate AAA+ disaggregase at aggregate surfaces.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 November 2018
Probing the different chaperone activities of the bacterial HSP70-HSP40 system using a thermolabile luciferase substrate
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 November 2018
Protein disaggregation by the AAA+ chaperone ClpB involves partial threading of looped polypeptide segments.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 November 2018
Substrate threading through the central pore of the Hsp104 chaperone as a common mechanism for protein disaggregation and prion propagation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 November 2018
Hsp70 chaperone machine remodels protein aggregates at the initial step of Hsp70-Hsp100-dependent disaggregation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 November 2018
Human and yeast Hsp110 chaperones exhibit functional differences
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 November 2018
Loops in the central channel of ClpA chaperone mediate protein binding, unfolding, and translocation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 November 2018
Successive and synergistic action of the Hsp70 and Hsp100 chaperones in protein disaggregation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 November 2018
Substrate recognition by the AAA+ chaperone ClpB.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 November 2018
Active solubilization and refolding of stable protein aggregates by cooperative unfolding action of individual hsp70 chaperones
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 November 2018
Evidence for an unfolding/threading mechanism for protein disaggregation by Saccharomyces cerevisiae Hsp104.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 November 2018
Identification of essential residues in the type II Hsp40 Sis1 that function in polypeptide binding
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 November 2018
Hsp101 is necessary for heat tolerance but dispensable for development and germination in the absence of stress.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 November 2018
Size-dependent disaggregation of stable protein aggregates by the DnaK chaperone machinery.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 November 2018
Heat shock protein 101 plays a crucial role in thermotolerance in Arabidopsis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 November 2018
Expression of APG-2 protein, a member of the heat shock protein 110 family, in developing rat brain.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 November 2018
Identification of a major subfamily of large hsp70-like proteins through the cloning of the mammalian 110-kDa heat shock protein.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4598581
retrieved
28 November 2018
The chaperoning activity of hsp110. Identification of functional domains by use of targeted deletions
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26501065
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The Arabidopsis ClpB/Hsp100 family of proteins: chaperones for stress and chloroplast development
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26501065
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Modulation of the chaperone activities of Hsc70/Hsp40 by Hsp105alpha and Hsp105beta
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26501065
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Interaction of the Hsp110 molecular chaperones from S. cerevisiae with substrate protein
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26501065
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.3389/FMOLB.2015.00057
1 reference
stated in
Europe PubMed Central
PMCID
4598581
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26501065%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 February 2020
PMCID
4598581
1 reference
stated in
Europe PubMed Central
PMCID
4598581
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26501065%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 February 2020
PubMed ID
26501065
1 reference
stated in
Europe PubMed Central
PMCID
4598581
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26501065%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 February 2020
ResearchGate publication ID
283328662
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