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Targeting ATM-deficient CLL through interference with DNA repair pathways
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title
Targeting ATM-deficient CLL through interference with DNA repair pathways
(English)
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author name string
Gero Knittel
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1
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Paul Liedgens
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2
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Hans C. Reinhardt
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3
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language of work or name
English
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publication date
2015
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Frontiers in Genetics
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volume
6
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page(s)
207
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PubMed
cites work
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DNA Damage, Aging, and Cancer
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A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage
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7 April 2017
ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2
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7 April 2017
The combined status of ATM and p53 link tumor development with therapeutic response
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7 April 2017
A tale of tails: insights into the coordination of 3' end processing during homologous recombination
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Somatic mutations affect key pathways in lung adenocarcinoma
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7 April 2017
Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage
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7 April 2017
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
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7 April 2017
Rapid activation of ATR by ionizing radiation requires ATM and Mre11
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7 April 2017
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks
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7 April 2017
Megabase chromatin domains involved in DNA double-strand breaks in vivo
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Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines
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Therapeutic targeting of a robust non-oncogene addiction to PRKDC in ATM-defective tumors
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7 April 2017
The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo.
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7 April 2017
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
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7 April 2017
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.
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7 April 2017
Factors determining DNA double-strand break repair pathway choice in G2 phase
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7 April 2017
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
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7 April 2017
The DNA damage response: putting checkpoints in perspective
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7 April 2017
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
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7 April 2017
Genome maintenance mechanisms for preventing cancer
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7 April 2017
A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome
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7 April 2017
Genomic aberrations and survival in chronic lymphocytic leukemia
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7 April 2017
Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl
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7 April 2017
Molecular pathways: exploiting tumor-specific molecular defects in DNA repair pathways for precision cancer therapy
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7 April 2017
Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response
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7 April 2017
Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia
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Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene
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7 April 2017
Mechanism of homologous recombination: mediators and helicases take on regulatory functions
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7 April 2017
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals
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7 April 2017
Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma
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7 April 2017
A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia
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ATR: an essential regulator of genome integrity
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Mechanism of eukaryotic homologous recombination
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ATM and related protein kinases: safeguarding genome integrity
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7 April 2017
Playing the end game: DNA double-strand break repair pathway choice
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Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
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7 April 2017
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
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Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
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7 April 2017
Cell cycle checkpoint signaling through the ATM and ATR kinases
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ATM-depletion in breast cancer cells confers sensitivity to PARP inhibition
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28 September 2017
Loss of p53 and altered miR15-a/16-1MCL-1 pathway in CLL: insights from TCL1-Tg:p53(-/-) mouse model and primary human leukemia cells
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28 September 2017
The ATM protein kinase: regulating the cellular response to genotoxic stress, and more
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Evolution and impact of subclonal mutations in chronic lymphocytic leukemia
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28 September 2017
Enhanced cytotoxicity of PARP inhibition in mantle cell lymphoma harbouring mutations in both ATM and p53
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28 September 2017
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28 September 2017
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28 September 2017
The role of homologous recombination in radiation-induced double-strand break repair
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28 September 2017
Sister chromatid exchanges occur in G2-irradiated cells
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28 September 2017
The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax
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28 September 2017
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28 September 2017
ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors
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28 September 2017
Aggressive chronic lymphocytic leukemia with elevated genomic complexity is associated with multiple gene defects in the response to DNA double-strand breaks.
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28 September 2017
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28 September 2017
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28 September 2017
ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin
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28 September 2017
Complementary functions of ATM and H2AX in development and suppression of genomic instability
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28 September 2017
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28 September 2017
Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin
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28 September 2017
Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin
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28 September 2017
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28 September 2017
DNA damage checkpoints: from initiation to recovery or adaptation
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28 September 2017
ATM stabilizes DNA double-strand-break complexes during V(D)J recombination.
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28 September 2017
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28 September 2017
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28 September 2017
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28 September 2017
A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461826
retrieved
28 September 2017
Repair of DNA double strand breaks by non-homologous end joining
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461826
retrieved
28 September 2017
DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461826
retrieved
28 September 2017
Ionizing radiation-induced Rad51 nuclear focus formation is cell cycle-regulated and defective in both ATM(-/-) and c-Abl(-/-) cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461826
retrieved
28 September 2017
Multiple mutations and cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461826
retrieved
28 September 2017
Synthetic lethality between mutation in Atm and DNA-PK(cs) during murine embryogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461826
retrieved
28 September 2017
The controlling role of ATM in homologous recombinational repair of DNA damage
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461826
retrieved
28 September 2017
Identification of defective illegitimate recombinational repair of oxidatively-induced DNA double-strand breaks in ataxia-telangiectasia cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461826
retrieved
28 September 2017
High frequency and error-prone DNA recombination in ataxia telangiectasia cell lines
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461826
retrieved
28 September 2017
Cancer risks from germline p53 mutations
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461826
retrieved
28 September 2017
DNA-PKcs and ATM co-regulate DNA double-strand break repair
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461826
retrieved
31 May 2018
Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461826
retrieved
31 May 2018
Control of sister chromatid recombination by histone H2AX.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461826
retrieved
31 May 2018
The genetic defect in ataxia-telangiectasia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461826
retrieved
31 May 2018
Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.3389%2FFGENE.2015.00207
retrieved
21 January 2018
Structure of the BRCT repeat domain of MDC1 and its specificity for the free COOH-terminal end of the gamma-H2AX histone tail
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.3389%2FFGENE.2015.00207
retrieved
21 January 2018
Genetic abnormalities and clinical outcome in chronic lymphocytic leukemia.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.3389%2FFGENE.2015.00207
retrieved
21 January 2018
Mouse models in the study of chronic lymphocytic leukemia pathogenesis and therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.3389%2FFGENE.2015.00207
retrieved
21 January 2018
Biallelic ATM inactivation significantly reduces survival in patients treated on the United Kingdom Leukemia Research Fund Chronic Lymphocytic Leukemia 4 trial.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.3389%2FFGENE.2015.00207
retrieved
21 January 2018
ATM gene deletion in patients with adult acute lymphoblastic leukemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461826
retrieved
28 November 2018
Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26113859
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
DNA damage checkpoints update: getting molecular
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26113859
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Chronic lymphocytic leukemia
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26113859
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26113859
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.3389%2FFGENE.2015.00207
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.3389/FGENE.2015.00207
0 references
PMCID
4461826
1 reference
stated in
PubMed
PubMed ID
26113859
1 reference
stated in
PubMed
ResearchGate publication ID
279278912
0 references
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