(Q26824468)

title

Advances and challenges in the differentiation of pluripotent stem cells into pancreatic β cells (English)

1 reference

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25621117%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

author name string

Mohamed M Emara

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25621117%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

language of work or name

1 reference

26 January 2015

1 reference

World Journal of Stem Cells

published in

2 references

Crossref

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25621117%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

volume

7

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25621117%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

issue

1

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25621117%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

page(s)

174-181

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25621117%20AND%20SRC:MED&resulttype=core&format=json

PAX4 enhances beta-cell differentiation of human embryonic stem cells

1 June 2020

cites work

1 reference

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7 April 2017

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A scalable system for production of functional pancreatic progenitors from human embryonic stem cells

7 April 2017

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Induction of pluripotent stem cells from adult human fibroblasts by defined factors

7 April 2017

1 reference

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7 April 2017

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Embryonic stem cell lines derived from human blastocysts

7 April 2017

1 reference

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Urocortin 3 regulates glucose-stimulated insulin secretion and energy homeostasis

7 April 2017

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Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

7 April 2017

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Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells

7 April 2017

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Efficient differentiation of human embryonic stem cells to definitive endoderm

7 April 2017

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Generation of insulin-producing β-like cells from human iPS cells in a defined and completely xeno-free culture system.

7 April 2017

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Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells

28 September 2017

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Endodermal differentiation of human pluripotent stem cells to insulin-producing cells in 3D culture

28 September 2017

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Pluripotent stem cells as a potential tool for disease modelling and cell therapy in diabetes.

28 September 2017

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Differentiated human stem cells resemble fetal, not adult, β cells

28 September 2017

1 reference

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Initial cell seeding density influences pancreatic endocrine development during in vitro differentiation of human embryonic stem cells

28 September 2017

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iPSC-derived β cells model diabetes due to glucokinase deficiency

28 September 2017

1 reference

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Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice

28 September 2017

1 reference

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Human embryonic stem cells derived by somatic cell nuclear transfer.

28 September 2017

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Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity

28 September 2017

1 reference

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Dynamic chromatin remodeling mediated by polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells

28 September 2017

1 reference

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Derivation of human induced pluripotent stem cells from patients with maturity onset diabetes of the young

28 September 2017

1 reference

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Cryopreservation of human insulin expressing cells macro-encapsulated in a durable therapeutic immunoisolating device theracyte.

28 September 2017

1 reference

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Transgene-free disease-specific induced pluripotent stem cells from patients with type 1 and type 2 diabetes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Intrapatient variations in type 1 diabetes-specific iPS cell differentiation into insulin-producing cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Maturation of human embryonic stem cell-derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Differentiation and transplantation of functional pancreatic beta cells generated from induced pluripotent stem cells derived from a type 1 diabetes mouse model.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Reprogrammed keratinocytes from elderly type 2 diabetes patients suppress senescence genes to acquire induced pluripotency

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

INS(GFP/w) human embryonic stem cells facilitate isolation of in vitro derived insulin-producing cells

28 September 2017

1 reference

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Small molecules induce efficient differentiation into insulin-producing cells from human induced pluripotent stem cells

28 September 2017

1 reference

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Discovering pluripotency: 30 years of mouse embryonic stem cells

28 September 2017

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Activin, BMP and FGF pathways cooperate to promote endoderm and pancreatic lineage cell differentiation from human embryonic stem cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Defining the nature of human pluripotent stem cell progeny

28 September 2017

1 reference

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Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells.

28 September 2017

1 reference

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Indolactam V/GLP-1-mediated differentiation of human iPS cells into glucose-responsive insulin-secreting progeny

28 September 2017

1 reference

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Production of functional glucagon-secreting α-cells from human embryonic stem cells

28 September 2017

1 reference

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Reversal of hyperglycemia in diabetic mouse models using induced-pluripotent stem (iPS)-derived pancreatic beta-like cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Pathogenesis, risk assessment and prevention of type 2 diabetes mellitus.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Generation of pluripotent stem cells from patients with type 1 diabetes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

A small molecule that directs differentiation of human ESCs into the pancreatic lineage.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

FGF4 and retinoic acid direct differentiation of hESCs into PDX1-expressing foregut endoderm in a time- and concentration-dependent manner

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Biphasic induction of Pdx1 in mouse and human embryonic stem cells can mimic development of pancreatic beta-cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Generation of insulin-secreting islet-like clusters from human skin fibroblasts

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Marked differences in differentiation propensity among human embryonic stem cell lines

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Type 1 diabetes: pathogenesis and prevention

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

The effect of overexpression of Pdx1 and Foxa2 on the differentiation of human embryonic stem cells into pancreatic cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Nodal signals pattern vertebrate embryos

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Cellular manipulation of human embryonic stem cells by TAT-PDX1 protein transduction

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Retinoic acid induces Pdx1-positive endoderm in differentiating mouse embryonic stem cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Development of definitive endoderm from embryonic stem cells in culture

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

beta-Cell death during progression to diabetes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Overexpression of PAX4 reduces glucagon expression in differentiating hESCs

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Dynamic signaling network for the specification of embryonic pancreas and liver progenitors

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Human embryonic stem cell derived islet progenitors mature inside an encapsulation device without evidence of increased biomass or cell escape.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

VMAT2 identified as a regulator of late-stage β-cell differentiation.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

The functional and molecular characterisation of human embryonic stem cell-derived insulin-positive cells compared with adult pancreatic beta cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Noggin, retinoids, and fibroblast growth factor regulate hepatic or pancreatic fate of human embryonic stem cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Generation of homogeneous PDX1(+) pancreatic progenitors from human ES cell-derived endoderm cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Generation of insulin-producing islet-like clusters from human embryonic stem cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Directed differentiation of human embryonic stem cells towards a pancreatic cell fate.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

In vitro derivation of functional insulin-producing cells from human embryonic stem cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4300928

Generation of pancreatic insulin-producing cells from rhesus monkey induced pluripotent stem cells

28 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/25621117

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.4252/WJSC.V7.I1.174

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25621117%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25621117%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

PubMed publication ID

25621117

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25621117%20AND%20SRC:MED&resulttype=core&format=json