(Q26824767)

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Beyond genotype to phenotype: why the phenotype of an individual cannot always be predicted from their genome sequence and the environment that they experience

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scholarly article

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Beyond genotype to phenotype: why the phenotype of an individual cannot always be predicted from their genome sequence and the environment that they experience (English)

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Ben Lehner

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author name string

Alejandro Burga

1

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language of work or name

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publication date

October 2012

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279

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20

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3765-75

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Predicting phenotypic variation in yeast from individual genome sequences.

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The genetic landscape of a cell

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Genetic interactions between transcription factors cause natural variation in yeast

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Heritability in the genomics era — concepts and misconceptions

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The Relative Importance of Heredity and Environment in Determining the Piebald Pattern of Guinea-Pigs

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A third component causing random variability beside environment and genotype. A reason for the limited success of a 30 year long effort to standardize laboratory animals?

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The Correlation between Relatives on the Supposition of Mendelian Inheritance

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Predicting mutation outcome from early stochastic variation in genetic interaction partners.

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Phenotypic differences in genetically identical organisms: the epigenetic perspective.

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Puberty and genetic susceptibility to breast cancer in a case-control study in twins

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Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profiles

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DNA methylation profiles in monozygotic and dizygotic twins.

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Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis

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Somatic retrotransposition alters the genetic landscape of the human brain

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Why are children in the same family so different from one another?

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Epidemiology, epigenetics and the 'Gloomy Prospect': embracing randomness in population health research and practice.

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Mir-290-295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defects

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Phenotypic variability and incomplete penetrance of spontaneous fractures in an inbred strain of transgenic mice expressing a mutated collagen gene (COL1A1)

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Non-genetic individuality: chance in the single cell

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Imaging individual mRNA molecules using multiple singly labeled probes

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Stochasticity in gene expression: from theories to phenotypes

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Stochastic gene expression in a single cell

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Control of stochasticity in eukaryotic gene expression

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Noise in protein expression scales with natural protein abundance

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Stochastic spineless expression creates the retinal mosaic for colour vision.

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Transcriptome-wide noise controls lineage choice in mammalian progenitor cells

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Variability in gene expression underlies incomplete penetrance

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Caenorhabditis elegans aristaless/Arx gene alr-1 restricts variable gene expression

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Fitness Trade-Offs and Environmentally Induced Mutation Buffering in Isogenic C. elegans

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Spontaneous epigenetic variation in the Arabidopsis thaliana methylome.

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Visualizing high error levels during gene expression in living bacterial cells.

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Intrinsic protein disorder and interaction promiscuity are widely associated with dosage sensitivity.

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The aggregation kinetics of Alzheimer's beta-amyloid peptide is controlled by stochastic nucleation

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Compartmentalization of gene expression during Bacillus subtilis spore formation

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Structure and evolution of the C. elegans embryonic endomesoderm network

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skn-1, a maternally expressed gene required to specify the fate of ventral blastomeres in the early C. elegans embryo

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21 January 2018

What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment?

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First experimental demonstration of the multipotential carcinogenic effects of aspartame administered in the feed to Sprague-Dawley rats

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A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans

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MicroRNA predictors of longevity in Caenorhabditis elegans

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Variable pathogenicity determines individual lifespan in Caenorhabditis elegans

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A regulatory network of T-box genes and the even-skipped homologue vab-7 controls patterning and morphogenesis in C. elegans

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Caenorhabditis elegans T-box genes tbx-9 and tbx-8 are required for formation of hypodermis and body-wall muscle in embryogenesis

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Transcription control reprogramming in genetic backup circuits

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Need-based up-regulation of protein levels in response to deletion of their duplicate genes

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Hsp90 as a capacitor for morphological evolution

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Chaperonin overexpression promotes genetic variation and enzyme evolution

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Hsp90 as a capacitor of phenotypic variation

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The maternal-zygotic transition: death and birth of RNAs

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Evidence for transgenerational transmission of epigenetic tumor susceptibility in Drosophila

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Widespread genetic incompatibility in C. elegans maintained by balancing selection

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Phenotypic plasticity and evolution by genetic assimilation

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Maternal effects provide phenotypic adaptation to local environmental conditions

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Transgenerational epigenetic effects.

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Transgenerational Epigenetic Inheritance: Prevalence, Mechanisms, and Implications for the Study of Heredity and Evolution

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Transgenerational plasticity is adaptive in the wild

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Genetic requirements for inheritance of RNAi in C. elegans

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Transmission dynamics of heritable silencing induced by double-stranded RNA in Caenorhabditis elegans

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RNAi mechanisms in Caenorhabditis elegans

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Animal virus replication and RNAi-mediated antiviral silencing in Caenorhabditis elegans

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Transgenerational inheritance of an acquired small RNA-based antiviral response in C. elegans

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Stable inheritance of an acquired behavior in Caenorhabditis elegans.

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Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans

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A C. elegans LSD1 demethylase contributes to germline immortality by reprogramming epigenetic memory

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Epigenetic inheritance at the agouti locus in the mouse

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Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission

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Genomic imprinting: parental influence on the genome

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Nongenomic transmission across generations of maternal behavior and stress responses in the rat

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RNA-mediated non-mendelian inheritance of an epigenetic change in the mouse

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Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

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Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals

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Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life

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Non-genomic transgenerational inheritance of disease risk

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Endonuclease-sensitive regions of human spermatozoal chromatin are highly enriched in promoter and CTCF binding sequences

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Sperm-derived histones contribute to zygotic chromatin in humans.

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The challenges of modeling mammalian biocomplexity

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Structure, function and diversity of the healthy human microbiome

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Transgenerational induction of defences in animals and plants

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Copy number variations are not modifiers of phenotypic expression in a pair of identical twins carrying a BRCA1 mutation

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Partial penetrance facilitates developmental evolution in bacteria.

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Distinctive chromatin in human sperm packages genes for embryo development

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The 'evolvability' of promiscuous protein functions

1 reference

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Heritability of liability and concordance in monozygous twins

1 reference

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10.1111/J.1742-4658.2012.08810.X

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