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Alpha Klotho and phosphate homeostasis
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PubMed
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Europe PubMed Central
title
Alpha Klotho and phosphate homeostasis
(English)
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stated in
PubMed
author name string
A. Bian
series ordinal
1
1 reference
stated in
Crossref
C. Xing
series ordinal
2
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Crossref
M. C. Hu
series ordinal
3
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stated in
Crossref
language of work or name
English
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stated in
PubMed
publication date
November 2014
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PubMed
published in
Journal of Endocrinological Investigation
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PubMed
volume
37
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PubMed
issue
11
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PubMed
page(s)
1121-6
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PubMed
cites work
Regulation of serum phosphate
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
7 April 2017
Skeletal secretion of FGF-23 regulates phosphate and vitamin D metabolism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
7 April 2017
The FGF23-Klotho axis: endocrine regulation of phosphate homeostasis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
7 April 2017
Suppression of aging in mice by the hormone Klotho
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
7 April 2017
Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
7 April 2017
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
7 April 2017
Role of FGF23 in vitamin D and phosphate metabolism: implications in chronic kidney disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
7 April 2017
Genetic disorders of phosphate regulation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
7 April 2017
A potential link between phosphate and aging--lessons from Klotho-deficient mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
7 April 2017
Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
7 April 2017
Klotho converts canonical FGF receptor into a specific receptor for FGF23
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
7 April 2017
Regulation of serum 1,25(OH)2 vitamin D3 levels by fibroblast growth factor 23 is mediated by FGF receptors 3 and 4
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
7 April 2017
Regulation of renal phosphate transport by FGF23 is mediated by FGFR1 and FGFR4
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
7 April 2017
Fibroblast growth factor 23 enhances renal klotho abundance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
7 April 2017
Downregulation of NaPi-IIa and NaPi-IIb Na-coupled phosphate transporters by coexpression of Klotho
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
7 April 2017
The parathyroid is a target organ for FGF23 in rats
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
7 April 2017
Type II Na+-Pi cotransporters in osteoblast mineral formation: regulation by inorganic phosphate
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
7 April 2017
Regulation of fibroblast growth factor-23 signaling by klotho
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
7 April 2017
Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
7 April 2017
αKlotho and vascular calcification: an evolving paradigm
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
Laboratory abnormalities in CKD-MBD: markers, predictors, or mediators of disease?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
The importance of klotho in phosphate metabolism and kidney disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
Associations of FGF-23 and sKlotho with cardiovascular outcomes among patients with CKD stages 2-4
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
FGF23 and Klotho in chronic kidney disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
Klotho and chronic kidney disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
Phosphate transporters of the SLC20 and SLC34 families
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
Renal and extrarenal actions of Klotho
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
A decreased level of serum soluble Klotho is an independent biomarker associated with arterial stiffness in patients with chronic kidney disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
Osteocyte regulation of phosphate homeostasis and bone mineralization underlies the pathophysiology of the heritable disorders of rickets and osteomalacia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
Phosphate transporters and their function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
Circulating αKlotho influences phosphate handling by controlling FGF23 production
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
FGF23 production by osteocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
Secreted klotho and chronic kidney disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
Klotho: a novel regulator of calcium and phosphorus homeostasis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
Intestinal phosphate transport.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
The regulation of parathyroid hormone secretion and synthesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
Klotho deficiency causes vascular calcification in chronic kidney disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
Phosphate homeostasis and the renal-gastrointestinal axis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
Regulation of rat intestinal Na-dependent phosphate transporters by dietary phosphate.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
Inactivation of klotho function induces hyperphosphatemia even in presence of high serum fibroblast growth factor 23 levels in a genetically engineered hypophosphatemic (Hyp) mouse model
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
Do osteocytes contribute to phosphate homeostasis?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
The Na+-Pi cotransporter PiT-2 (SLC20A2) is expressed in the apical membrane of rat renal proximal tubules and regulated by dietary Pi
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
The mechanism of phosphorus as a cardiovascular risk factor in CKD
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
A translocation causing increased alpha-klotho level results in hypophosphatemic rickets and hyperparathyroidism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
Proximal tubular handling of phosphate: A molecular perspective
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
Klotho as a regulator of fibroblast growth factor signaling and phosphate/calcium metabolism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
Physiological regulation of renal sodium-dependent phosphate cotransporters
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
Regulation of phosphate (Pi) transport and NaPi-III transporter (Pit-1) mRNA in rat osteoblasts.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
Expression of type III sodium-dependent phosphate transporters/retroviral receptors mRNAs during osteoblast differentiation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
Independent impairment of osteoblast and osteoclast differentiation in klotho mouse exhibiting low-turnover osteopenia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
Parathyroid hormone gene expression in hypophosphatemic rats
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
Consequences of phosphate imbalance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 September 2017
Vitamin D receptor-independent FGF23 actions in regulating phosphate and vitamin D metabolism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1007%2FS40618-014-0158-6
retrieved
21 January 2018
Parathyroid cell proliferation in normal and chronic renal failure rats. The effects of calcium, phosphate, and vitamin D.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1007%2FS40618-014-0158-6
retrieved
21 January 2018
Compensatory regulation of the sodium/phosphate cotransporters NaPi-IIc (SCL34A3) and Pit-2 (SLC20A2) during Pi deprivation and acidosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1007%2FS40618-014-0158-6
retrieved
21 January 2018
PiT-2 coming out of the pits.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1007%2FS40618-014-0158-6
retrieved
21 January 2018
Altered distribution of bone matrix proteins and defective bone mineralization in klotho-deficient mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1007%2FS40618-014-0158-6
retrieved
21 January 2018
Phosphate overload directly induces systemic inflammation and malnutrition as well as vascular calcification in uremia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1007%2FS40618-014-0158-6
retrieved
21 January 2018
Vitamin K, bone fractures, and vascular calcifications in chronic kidney disease: an important but poorly studied relationship
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1007%2FS40618-014-0158-6
retrieved
21 January 2018
Hypervitaminosis D and premature aging: lessons learned from Fgf23 and Klotho mutant mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1007%2FS40618-014-0158-6
retrieved
21 January 2018
Cloning and characterization of a type III Na-dependent phosphate cotransporter from mouse intestine.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 November 2018
Na+-dependent phosphate cotransporters: the NaPi protein families.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485939
retrieved
28 November 2018
Correlation between hyperphosphatemia and type II Na-Pi cotransporter activity in klotho mice
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25194425
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Elongation of the epiphyseal trabecular bone in transgenic mice carrying a klotho gene locus mutation that leads to a syndrome resembling aging
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25194425
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Characterization of vitamin D-deficient klotho(-/-) mice: do increased levels of serum 1,25(OH)2D3 cause disturbed calcium and phosphate homeostasis in klotho(-/-) mice?
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25194425
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Circulating Klotho levels: clinical relevance and relationship with tissue Klotho expression
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25194425
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Circulating α-klotho levels in CKD and relationship to progression
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25194425
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1007/S40618-014-0158-6
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Dimensions Publication ID
1047790109
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PMC publication ID
4485939
1 reference
stated in
PubMed
PubMed publication ID
25194425
1 reference
stated in
PubMed
ResearchGate publication ID
265391819
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