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Structural insights on the role of antibodies in HIV-1 vaccine and therapy
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PubMed
title
Structural insights on the role of antibodies in HIV-1 vaccine and therapy
(English)
1 reference
stated in
PubMed
main subject
antibody
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based on heuristic
inferred from title
vaccine
1 reference
based on heuristic
inferred from title
author
Johannes F Scheid
series ordinal
3
object named as
Johannes F. Scheid
1 reference
stated in
Crossref
Michel C. Nussenzweig
series ordinal
6
object named as
Michel C. Nussenzweig
1 reference
stated in
Crossref
author name string
Anthony P. West
series ordinal
1
1 reference
stated in
Crossref
Louise Scharf
series ordinal
2
1 reference
stated in
Crossref
Florian Klein
series ordinal
4
1 reference
stated in
Crossref
Pamela J. Bjorkman
series ordinal
5
1 reference
stated in
Crossref
language of work or name
English
1 reference
stated in
PubMed
publication date
13 February 2014
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stated in
PubMed
published in
Cell
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stated in
PubMed
volume
156
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stated in
PubMed
issue
4
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stated in
PubMed
page(s)
633-48
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stated in
PubMed
cites work
A Blueprint for HIV Vaccine Discovery
1 reference
stated in
PubMed Central
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HIV-1 superinfection in women broadens and strengthens the neutralizing antibody response
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Increasing the potency and breadth of an HIV antibody by using structure-based rational design
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7 April 2017
Few and far between: how HIV may be evading antibody avidity
1 reference
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7 April 2017
HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors
1 reference
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PubMed Central
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7 April 2017
Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome
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7 April 2017
Antibodies in HIV-1 vaccine development and therapy
1 reference
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PubMed Central
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7 April 2017
Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies
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Structural Basis for Enhanced HIV-1 Neutralization by a Dimeric Immunoglobulin G Form of the Glycan-Recognizing Antibody 2G12
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7 April 2017
Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer
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7 April 2017
Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer
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7 April 2017
Prefusion structure of trimeric HIV-1 envelope glycoprotein determined by cryo-electron microscopy
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7 April 2017
Autoreactivity and Exceptional CDR Plasticity (but Not Unusual Polyspecificity) Hinder Elicitation of the Anti-HIV Antibody 4E10
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7 April 2017
Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies
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7 April 2017
Restricting HIV-1 pathways for escape using rationally designed anti–HIV-1 antibodies
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7 April 2017
Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16
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7 April 2017
Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120
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7 April 2017
Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization
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7 April 2017
Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans
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7 April 2017
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
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7 April 2017
Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization
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Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors
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Broad and potent neutralization of HIV-1 by a gp41-specific human antibody
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7 April 2017
Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies
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Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9
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7 April 2017
A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield
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7 April 2017
Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing
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A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins
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Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding
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An anti-HIV-1 V3 loop antibody fully protects cross-clade and elicits T-cell immunity in macaques mucosally challenged with an R5 clade C SHIV
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Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01
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Molecular architecture of native HIV-1 gp120 trimers
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A fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies
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HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane
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Antibody domain exchange is an immunological solution to carbohydrate cluster recognition
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Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody
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A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies
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Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target
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HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites
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Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1
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Broadly neutralizing antibodies that inhibit HIV-1 cell to cell transmission
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Viral escape from HIV-1 neutralizing antibodies drives increased plasma neutralization breadth through sequential recognition of multiple epitopes and immunotypes
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Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys
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Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia
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Recognition of synthetic glycopeptides by HIV-1 broadly neutralizing antibodies and their unmutated ancestors.
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HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice
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Immune tolerance negatively regulates B cells in knock-in mice expressing broadly neutralizing HIV antibody 4E10
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Common tolerance mechanisms, but distinct cross-reactivities associated with gp41 and lipids, limit production of HIV-1 broad neutralizing antibodies 2F5 and 4E10
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Computational analysis of anti-HIV-1 antibody neutralization panel data to identify potential functional epitope residues
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Antibody and antiretroviral preexposure prophylaxis prevent cervicovaginal HIV-1 infection in a transgenic mouse model
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Genome-wide association study on the development of cross-reactive neutralizing antibodies in HIV-1 infected individuals
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Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies
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Recombinant HIV envelope proteins fail to engage germline versions of anti-CD4bs bNAbs
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Most rhesus macaques infected with the CCR5-tropic SHIV(AD8) generate cross-reactive antibodies that neutralize multiple HIV-1 strains
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HIV therapy by a combination of broadly neutralizing antibodies in humanized mice.
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Evolution of an HIV glycan-dependent broadly neutralizing antibody epitope through immune escape
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28 September 2017
Broadly neutralizing antibodies developed by an HIV-positive elite neutralizer exact a replication fitness cost on the contemporaneous virus
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28 September 2017
Plasma HIV viral rebound following protocol-indicated cessation of ART commenced in primary and chronic HIV infection
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28 September 2017
Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein
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28 September 2017
Structural basis for germ-line gene usage of a potent class of antibodies targeting the CD4-binding site of HIV-1 gp120.
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28 September 2017
Early low-titer neutralizing antibodies impede HIV-1 replication and select for virus escape
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28 September 2017
Pathogenicity and mucosal transmissibility of the R5-tropic simian/human immunodeficiency virus SHIV(AD8) in rhesus macaques: implications for use in vaccine studies
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28 September 2017
B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study
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28 September 2017
Outwitting evolution: fighting drug-resistant TB, malaria, and HIV.
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28 September 2017
Germinal centers
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28 September 2017
Enhanced HIV-1 neutralization by antibody heteroligation
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28 September 2017
Antibody-based protection against HIV infection by vectored immunoprophylaxis
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28 September 2017
Rapid development of glycan-specific, broad, and potent anti-HIV-1 gp120 neutralizing antibodies in an R5 SIV/HIV chimeric virus infected macaque
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28 September 2017
Potent intratype neutralizing activity distinguishes human immunodeficiency virus type 2 (HIV-2) from HIV-1
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28 September 2017
Potent autologous and heterologous neutralizing antibody responses occur in HIV-2 infection across a broad range of infection outcomes
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28 September 2017
Polyreactive antibodies in adaptive immune responses to viruses
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28 September 2017
Differential reactivity of germ line allelic variants of a broadly neutralizing HIV-1 antibody to a gp41 fusion intermediate conformation
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28 September 2017
Cross-reactive HIV-1-neutralizing human monoclonal antibodies identified from a patient with 2F5-like antibodies
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28 September 2017
Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestors
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28 September 2017
Longer V1V2 region with increased number of potential N-linked glycosylation sites in the HIV-1 envelope glycoprotein protects against HIV-specific neutralizing antibodies
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28 September 2017
Acute HIV-1 Infection
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28 September 2017
The neutralization breadth of HIV-1 develops incrementally over four years and is associated with CD4+ T cell decline and high viral load during acute infection
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28 September 2017
Characteristics of the earliest cross-neutralizing antibody response to HIV-1.
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28 September 2017
New templates for HIV-1 antibody-based vaccine design
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28 September 2017
B-cell depletion reveals a role for antibodies in the control of chronic HIV-1 infection
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28 September 2017
Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation
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28 September 2017
Optimal antiretroviral therapy: HIV-1 treatment strategies to avoid and overcome drug resistance
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28 September 2017
Human anti-HIV-neutralizing antibodies frequently target a conserved epitope essential for viral fitness
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28 September 2017
Infection by discordant strains of HIV-1 markedly enhances the neutralizing antibody response against heterologous virus
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28 September 2017
The role of antibodies in HIV vaccines
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28 September 2017
Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals
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28 September 2017
Relationship between antibody 2F5 neutralization of HIV-1 and hydrophobicity of its heavy chain third complementarity-determining region
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28 September 2017
Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance
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28 September 2017
The immune response during acute HIV-1 infection: clues for vaccine development
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28 September 2017
Breadth of human immunodeficiency virus-specific neutralizing activity in sera: clustering analysis and association with clinical variables
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28 September 2017
Role of HIV membrane in neutralization by two broadly neutralizing antibodies
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28 September 2017
Germline-like predecessors of broadly neutralizing antibodies lack measurable binding to HIV-1 envelope glycoproteins: implications for evasion of immune responses and design of vaccine immunogens
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28 September 2017
The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection
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28 September 2017
Human immunodeficiency virus type 1 elite neutralizers: individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithm
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28 September 2017
Meta-analytical studies on the epidemiology, prevention, and treatment of human immunodeficiency virus infection
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28 September 2017
Examination of the contributions of size and avidity to the neutralization mechanisms of the anti-HIV antibodies b12 and 4E10.
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28 September 2017
Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals
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28 September 2017
Factors associated with the development of cross-reactive neutralizing antibodies during human immunodeficiency virus type 1 infection
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28 September 2017
Frequency and phenotype of human immunodeficiency virus envelope-specific B cells from patients with broadly cross-neutralizing antibodies
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28 September 2017
Initial B-cell responses to transmitted human immunodeficiency virus type 1: virion-binding immunoglobulin M (IgM) and IgG antibodies followed by plasma anti-gp41 antibodies with ineffective control of initial viremia
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28 September 2017
Profiling the specificity of neutralizing antibodies in a large panel of plasmas from patients chronically infected with human immunodeficiency virus type 1 subtypes B and C.
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28 September 2017
Passive immunization as tool to identify protective HIV-1 Env epitopes
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28 September 2017
Broad HIV-1 neutralization mediated by CD4-binding site antibodies
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28 September 2017
Adjunctive passive immunotherapy in human immunodeficiency virus type 1-infected individuals treated with antiviral therapy during acute and early infection
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28 September 2017
Neutralizing antibody responses in acute human immunodeficiency virus type 1 subtype C infection
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28 September 2017
Autoreactivity in human IgG+ memory B cells
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28 September 2017
An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10
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28 September 2017
Human immunodeficiency virus type 1 V1-V2 envelope loop sequences expand and add glycosylation sites over the course of infection, and these modifications affect antibody neutralization sensitivity
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28 September 2017
HIV/AIDS epidemiology, pathogenesis, prevention, and treatment
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28 September 2017
Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus
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28 September 2017
Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies.
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28 September 2017
Anti-human immunodeficiency virus type 1 (HIV-1) antibodies 2F5 and 4E10 require surprisingly few crucial residues in the membrane-proximal external region of glycoprotein gp41 to neutralize HIV-1.
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28 September 2017
Identifying epitopes of HIV-1 that induce protective antibodies
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28 September 2017
Increased mucosal transmission but not enhanced pathogenicity of the CCR5-tropic, simian AIDS-inducing simian/human immunodeficiency virus SHIV(SF162P3) maps to envelope gp120.
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28 September 2017
The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1-->2 mannose residues on the outer face of gp120.
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28 September 2017
Envelope glycoprotein incorporation, not shedding of surface envelope glycoprotein (gp120/SU), Is the primary determinant of SU content of purified human immunodeficiency virus type 1 and simian immunodeficiency virus
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28 September 2017
Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41.
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28 September 2017
Immunoglobulin heavy chain expression shapes the B cell receptor repertoire in human B cell development
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28 September 2017
Neutralizing antibodies have limited effects on the control of established HIV-1 infection in vivo.
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28 September 2017
Human immunodeficiency virus type 1 neutralizing antibodies accelerate clearance of cell-free virions from blood plasma
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28 September 2017
Affinity dependence of the B cell response to antigen: a threshold, a ceiling, and the importance of off-rate
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28 September 2017
Plasma viremia as a sensitive indicator of the antiretroviral activity of L-697,661.
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28 September 2017
A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1
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28 September 2017
Human monoclonal antibody that recognizes the V3 region of human immunodeficiency virus gp120 and neutralizes the human T-lymphotropic virus type IIIMN strain
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28 September 2017
Neutralization of diverse human immunodeficiency virus type 1 variants by an anti-V3 human monoclonal antibody
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28 September 2017
Induction of HIV-1 broad neutralizing antibodies in 2F5 knock-in mice: selection against membrane proximal external region-associated autoreactivity limits T-dependent responses
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31 May 2018
Epitope mapping of broadly neutralizing HIV-2 human monoclonal antibodies
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31 May 2018
Epitope exposure on functional, oligomeric HIV-1 gp41 molecules
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31 May 2018
Antibody response to human immunodeficiency virus after primary infection
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31 May 2018
Kinetic maturation of an immune response
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31 May 2018
Transient High Levels of Viremia in Patients with Primary Human Immunodeficiency Virus Type 1 Infection
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31 May 2018
Prevention of HIV infection by passive immunization with HIV immunoglobulin
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31 May 2018
A human monoclonal antibody against the CD4-binding site of HIV1 gp120 exhibits potent, broadly neutralizing activity
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31 May 2018
Broadly neutralizing antibodies and the search for an HIV-1 vaccine: the end of the beginning
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041625
retrieved
28 November 2018
Design and expression of a dimeric form of human immunodeficiency virus type 1 antibody 2G12 with increased neutralization potency
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041625
retrieved
28 November 2018
Delay of HIV-1 rebound after cessation of antiretroviral therapy through passive transfer of human neutralizing antibodies
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041625
retrieved
28 November 2018
IMGT unique numbering for the variable (V), constant (C), and groove (G) domains of IG, TR, MH, IgSF, and MhSF
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24529371
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Codon bias targets mutation.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24529371
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Advances in antiretroviral therapy
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24529371
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
hu-PBL-SCID mice can be protected from HIV-1 infection by passive transfer of monoclonal antibody to the principal neutralizing determinant of envelope gp120
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24529371
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24529371
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.CELL.2014.01.052
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
244703
OpenCitations bibliographic resource ID
244703
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
244703
PMC publication ID
4041625
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
244703
PubMed publication ID
24529371
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
244703
ResearchGate publication ID
260217648
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