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Proteostasis and longevity: when does aging really begin?
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review article
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title
Proteostasis and longevity: when does aging really begin?
(English)
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PubMed
author name string
John Labbadia
series ordinal
1
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Richard I. Morimoto
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2
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English
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publication date
2014
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F1000prime reports
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volume
6
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page(s)
7
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PubMed
cites work
Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging
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PubMed Central
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Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways
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PubMed Central
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7 April 2017
Widespread protein aggregation as an inherent part of aging in C. elegans
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PubMed Central
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7 April 2017
The hallmarks of aging
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PubMed Central
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7 April 2017
Adapting proteostasis for disease intervention
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PubMed Central
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7 April 2017
Proteasome dysfunction in Drosophila signals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging
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PubMed Central
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7 April 2017
Stress-activated cap'n'collar transcription factors in aging and human disease
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7 April 2017
Evolution of ageing
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PubMed Central
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7 April 2017
The unfolded protein response: from stress pathway to homeostatic regulation
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PubMed Central
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7 April 2017
The genetics of ageing
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PubMed Central
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7 April 2017
Recognition and processing of ubiquitin-protein conjugates by the proteasome
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PubMed Central
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7 April 2017
Autophagy and aging
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PubMed Central
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7 April 2017
The cell-non-autonomous nature of electron transport chain-mediated longevity
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PubMed Central
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Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging
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PubMed Central
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7 April 2017
Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914504
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7 April 2017
Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor
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PubMed Central
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7 April 2017
Signals from the reproductive system regulate the lifespan of C. elegans
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914504
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7 April 2017
XBP-1 is a cell-nonautonomous regulator of stress resistance and longevity
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PubMed Central
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28 September 2017
REGγ deficiency promotes premature aging via the casein kinase 1 pathway
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PubMed Central
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28 September 2017
Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan
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PubMed Central
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28 September 2017
DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity
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stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914504
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28 September 2017
The nascent polypeptide-associated complex is a key regulator of proteostasis
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914504
retrieved
28 September 2017
Declining signal dependence of Nrf2-MafS-regulated gene expression correlates with aging phenotypes
1 reference
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PubMed Central
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28 September 2017
Evaluating and responding to mitochondrial dysfunction: the mitochondrial unfolded-protein response and beyond
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PubMed Central
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28 September 2017
Initial quantitative proteomic map of 28 mouse tissues using the SILAC mouse
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PubMed Central
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28 September 2017
Direct and indirect gene regulation by a life-extending FOXO protein in C. elegans: roles for GATA factors and lipid gene regulators
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PubMed Central
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28 September 2017
Genetics of longevity in model organisms: debates and paradigm shifts
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PubMed Central
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28 September 2017
The unfolded protein response in secretory cell function.
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PubMed Central
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28 September 2017
Quantitative in vivo redox sensors uncover oxidative stress as an early event in life
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PubMed Central
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28 September 2017
Ribosome-associated chaperones as key players in proteostasis
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stated in
PubMed Central
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28 September 2017
Proteomic analysis of age-dependent changes in protein solubility identifies genes that modulate lifespan
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PubMed Central
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28 September 2017
Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae
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PubMed Central
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28 September 2017
Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914504
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28 September 2017
Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteins
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914504
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28 September 2017
EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914504
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28 September 2017
Autophagy in the cellular energetic balance
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914504
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28 September 2017
A longer and healthier life with TOR down-regulation: genetics and drugs
1 reference
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PubMed Central
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28 September 2017
A screenable in vivo assay to study proteostasis networks in Caenorhabditis elegans
1 reference
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PubMed Central
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28 September 2017
Can autophagy promote longevity?
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914504
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28 September 2017
Heat shock factors: integrators of cell stress, development and lifespan.
1 reference
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PubMed Central
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28 September 2017
Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914504
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28 September 2017
The Caenorhabditis elegans germ line regulates distinct signaling pathways to control lifespan and innate immunity
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914504
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28 September 2017
A conserved ubiquitination pathway determines longevity in response to diet restriction
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PubMed Central
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28 September 2017
Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1
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PubMed Central
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28 September 2017
Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat.
1 reference
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PubMed Central
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28 September 2017
Genetic and pharmacological factors that influence reproductive aging in nematodes
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914504
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28 September 2017
Microarray analysis of variation in individual aging C. elegans: approaches and challenges
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914504
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28 September 2017
Measurements of age-related changes of physiological processes that predict lifespan of Caenorhabditis elegans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914504
retrieved
28 September 2017
Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914504
retrieved
28 September 2017
Decreased levels of proteasome activity and proteasome expression in aging spinal cord
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914504
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28 September 2017
Concomitant decline in heat-induced hyperthermia and HSP70 mRNA expression in aged rats
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914504
retrieved
28 September 2017
Stress-induced heat shock protein 70 expression in adrenal cortex: an adrenocorticotropic hormone-sensitive, age-dependent response
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914504
retrieved
28 September 2017
Functional aging in the nervous system contributes to age-dependent motor activity decline in C. elegans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914504
retrieved
31 May 2018
FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914504
retrieved
31 May 2018
Germline stem cell arrest inhibits the collapse of somatic proteostasis early in Caenorhabditis elegans adulthood.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914504
retrieved
28 November 2018
RPN-6 determines C. elegans longevity under proteotoxic stress conditions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914504
retrieved
28 November 2018
A photoconvertible reporter of the ubiquitin-proteasome system in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914504
retrieved
28 November 2018
Genetic evidence linking age-dependent attenuation of the 26S proteasome with the aging process
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914504
retrieved
28 November 2018
Post-eclosion decline in 'knock-down' thermal resistance and reduced effect of heat hardening in Drosophila melanogaster.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914504
retrieved
28 November 2018
Transcriptional profile of aging in C. elegans.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914504
retrieved
28 November 2018
Regulation of life-span by germ-line stem cells in Caenorhabditis elegans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914504
retrieved
28 November 2018
Fibroblast cultures from healthy centenarians have an active proteasome
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24592319
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24592319
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.12703/P6-7
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2113392
Fatcat ID
release_crjdw63hmbctfnpjsfkqwurj4u
1 reference
stated in
Fatcat
reference URL
https://api.fatcat.wiki/v0/release/crjdw63hmbctfnpjsfkqwurj4u
retrieved
24 November 2022
based on heuristic
mapped directly with Wikidata item
OpenCitations bibliographic resource ID
2113392
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2113392
PMCID
3914504
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2113392
PubMed ID
24592319
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2113392
ResearchGate publication ID
260487211
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