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Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan
scientific article published on 6 May 2013
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Europe PubMed Central
PMC publication ID
3666724
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23650379%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 February 2020
title
Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan
(English)
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PMC publication ID
3666724
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29 February 2020
main subject
overexpression
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inferred from title
lifetime
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author
Michael Rera
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2
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Europe PubMed Central
PMC publication ID
3666724
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29 February 2020
author name string
Anil Rana
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1
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PMC publication ID
3666724
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29 February 2020
David W Walker
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3
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3666724
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29 February 2020
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English
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publication date
6 May 2013
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29 February 2020
published in
Proceedings of the National Academy of Sciences of the United States of America
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PMC publication ID
3666724
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29 February 2020
volume
110
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3666724
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29 February 2020
issue
21
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PMC publication ID
3666724
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29 February 2020
page(s)
8638-8643
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PMC publication ID
3666724
reference URL
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29 February 2020
cites work
Mitochondrial fission, fusion, and stress
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
Overexpression of parkin ameliorates dopaminergic neurodegeneration induced by 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
The pathways of mitophagy for quality control and clearance of mitochondria
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
Mitochondrial quality control: a matter of life and death for neurons
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
Proteomic analysis of age-dependent changes in protein solubility identifies genes that modulate lifespan
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
Aging as an event of proteostasis collapse
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
Mechanisms of mitophagy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
Parkinson's Disease: Genetics and Pathogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
Widespread protein aggregation as an inherent part of aging in C. elegans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
The PINK1/Parkin pathway: a mitochondrial quality control system?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
The Drosophila PGC-1 homologue Spargel coordinates mitochondrial activity to insulin signalling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
The emerging complexity of protein ubiquitination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
Recognition and processing of ubiquitin-protein conjugates by the proteasome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
Prandiology of Drosophila and the CAFE assay.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
Hypersensitivity to oxygen and shortened lifespan in a Drosophila mitochondrial complex II mutant
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
A century-old debate on protein aggregation and neurodegeneration enters the clinic
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
Transcriptional profiling of aging in human muscle reveals a common aging signature
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
Metabolic control through the PGC-1 family of transcription coactivators
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
Sex and death: what is the connection?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
Mitochondrial "swirls" induced by oxygen stress and in the Drosophila mutant hyperswirl
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
Stress resistance as a determinate of C. elegans lifespan
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
P[Switch], a system for spatial and temporal control of gene expression in Drosophila melanogaster
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
A conditional tissue-specific transgene expression system using inducible GAL4.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
The ubiquitin system
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
29 September 2017
Expression of yeast NDI1 rescues a Drosophila complex I assembly defect
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
27 June 2018
FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
27 June 2018
Expression of Pink1 with α-synuclein in the dopaminergic neurons of Drosophila leads to increases in both lifespan and healthspan.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
4 September 2018
How could Parkin-mediated ubiquitination of mitofusin promote mitophagy?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666724
retrieved
4 September 2018
Benchmarks for ageing studies
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23650379
retrieved
12 December 2020
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Identifiers
DOI
10.1073/PNAS.1216197110
1 reference
stated in
Europe PubMed Central
PMC publication ID
3666724
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23650379%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 February 2020
ADS bibcode
2013PNAS..110.8638R
0 references
PMC publication ID
3666724
1 reference
stated in
Europe PubMed Central
PMC publication ID
3666724
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23650379%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 February 2020
PubMed publication ID
23650379
1 reference
stated in
Europe PubMed Central
PMC publication ID
3666724
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23650379%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 February 2020
ResearchGate publication ID
236644077
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