(Q36628151)

15 August 2017

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title

A century-old debate on protein aggregation and neurodegeneration enters the clinic (English)

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15 August 2017

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2

Hilal A Lashuel

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15 August 2017

Peter T Lansbury

1

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PubMed ID

17051203

15 August 2017

language of work or name

English

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publication date

1 October 2006

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15 August 2017

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15 August 2017

443

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15 August 2017

774-779

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15 August 2017

7113

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https://scigraph.springernature.com/pub.10.1038/nature05290

15 August 2017

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cites work

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21 January 2018

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21 January 2018

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21 January 2018

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Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brain.

21 January 2018

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Imaging technology for neurodegenerative diseases: progress toward detection of specific pathologies

21 January 2018

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Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans.

21 January 2018

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Does my mouse have Alzheimer's disease?

21 January 2018

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Alpha-synuclein and transgenic mouse models

21 January 2018

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Apolipoprotein E alleles as risk factors in Alzheimer's disease

21 January 2018

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A polymorphic variation of serine to tyrosine at codon 18 in the ubiquitin C-terminal hydrolase-L1 gene is associated with a reduced risk of sporadic Parkinson's disease in a Japanese population

21 January 2018

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Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

21 January 2018

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Opinion: What is the role of protein aggregation in neurodegeneration?

21 January 2018

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

21 January 2018

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Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

21 January 2018

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Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.

21 January 2018

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Identification of normal and pathological aging in prospectively studied nondemented elderly humans

21 January 2018

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Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer's disease brains

21 January 2018

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Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions

21 January 2018

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Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

21 January 2018

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A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.

21 January 2018

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Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

21 January 2018

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Neuronal dysfunction in a polyglutamine disease model occurs in the absence of ubiquitin-proteasome system impairment and inversely correlates with the degree of nuclear inclusion formation

21 January 2018

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Isolation of amyloid deposits from brain.

21 January 2018

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Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate.

21 January 2018

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Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

21 January 2018

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Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3beta

21 January 2018

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Amyloid ion channels: a common structural link for protein-misfolding disease

21 January 2018

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Neurodegenerative disease: amyloid pores from pathogenic mutations.

21 January 2018

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Mixtures of wild-type and a pathogenic (E22G) form of Abeta40 in vitro accumulate protofibrils, including amyloid pores.

21 January 2018

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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

21 January 2018

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Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers.

21 January 2018

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Opposing activities protect against age-onset proteotoxicity

21 January 2018

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Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

21 January 2018

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Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein

21 January 2018

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Huntingtin spheroids and protofibrils as precursors in polyglutamine fibrilization

21 January 2018

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Human amylin oligomer growth and fibril elongation define two distinct phases in amyloid formation

21 January 2018

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Protein folding and misfolding

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE05290

Formation of morphologically similar globular aggregates from diverse aggregation-prone proteins in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE05290

Characterization of cytoplasmic alpha-synuclein aggregates. Fibril formation is tightly linked to the inclusion-forming process in cells

21 January 2018

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A specific amyloid-beta protein assembly in the brain impairs memory

21 January 2018

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The most infectious prion protein particles.

21 January 2018

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Morphology and toxicity of Abeta-(1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer's disease.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE05290

Annular alpha-synuclein species from purified multiple system atrophy inclusions.

21 January 2018

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alpha-Synuclein locus triplication causes Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE05290

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

21 January 2018

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The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

21 January 2018

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Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE05290

The E46K mutation in alpha-synuclein increases amyloid fibril formation.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE05290

Pathogenic superoxide dismutase structure, folding, aggregation and turnover

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE05290

Rapid disease progression correlates with instability of mutant SOD1 in familial ALS

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE05290

Cause of neural death in neurodegenerative diseases attributable to expansion of glutamine repeats

21 January 2018

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Molecular genetics: unmasking polyglutamine triggers in neurodegenerative disease

21 January 2018

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Structural neurology: are seeds at the root of neuronal degeneration?

21 January 2018

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The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE05290

Molecular basis of phenotypic variability in sporadic Creutzfeldt-Jakob disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05290

The IVS1 +319 t>a of SOD1 gene is not an ALS causing mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05290

Interaction between A beta(1-42) and A beta(1-40) in Alzheimer's beta-amyloid fibril formation in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05290

Acceleration of amyloid beta-peptide aggregation by physiological concentrations of calcium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05290

Oligomerization of amyloid beta-protein occurs during the isolation of lipid rafts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05290

Neurotoxic protein oligomers--what you see is not always what you get.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05290

Differential effects of oligomeric and fibrillar amyloid-beta 1-42 on astrocyte-mediated inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05290

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05290

Proteasomal inhibition by alpha-synuclein filaments and oligomers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05290

Golgi fragmentation occurs in the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05290

Loss of autophagy in the central nervous system causes neurodegeneration in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05290

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05290

Familial parkinsonism with synuclein pathology: clinical and PET studies of A30P mutation carriers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05290

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05290

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05290

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05290

Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05290

Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05290

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05290

Selective inhibition of Abeta42 production by NSAID R-enantiomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05290

NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05290

Aggresomes, inclusion bodies and protein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05290

Collaborative Analysis of α-Synuclein Gene Promoter Variability and Parkinson Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05290

Molecular genetics and transgenic model of Gertsmann-Sträussler-Scheinker disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05290

7 January 2021

Amyotrophic lateral sclerosis. Clinical features and prognosis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05290

7 January 2021

The effects of additional pathology on the cognitive deficit in Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05290

7 January 2021

Observation of metastable Abeta amyloid protofibrils by atomic force microscopy

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05290

7 January 2021

Protofibrillar islet amyloid polypeptide permeabilizes synthetic vesicles by a pore-like mechanism that may be relevant to type II diabetes

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05290

7 January 2021

Disruption of prion rods generates 10-nm spherical particles having high alpha-helical content and lacking scrapie infectivity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05290

7 January 2021

Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05290

7 January 2021

Plasma amyloid beta-peptide 1-42 and incipient Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05290

7 January 2021

Compound heterozygous D90A and D96N SOD1 mutations in a recessive amyotrophic lateral sclerosis family

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05290

7 January 2021

Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05290

7 January 2021

Identifiers

DOI

10.1038/NATURE05290

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15 August 2017

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PubMed ID

17051203