(Q26851305)

language of work or name

1 reference

September 2013

1 reference

Journal of Internal Medicine

published in

1 reference

volume

274

1 reference

issue

3

1 reference

page(s)

203-14

1 reference

Islet beta cell failure in type 2 diabetes

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

The influence of genetic background on the expression of the obese (ob) gene in the mouse

21 January 2018

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https://api.crossref.org/works/10.1111%2FJOIM.12096

Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice

21 January 2018

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https://api.crossref.org/works/10.1111%2FJOIM.12096

Diet-induced type II diabetes in C57BL/6J mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Differential effect of inbred mouse strain (C57BL/6, DBA/2, 129T2) on insulin secretory function in response to a high fat diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Comparison of insulin secretory function in two mouse models with different susceptibility to beta-cell failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Variation in type 2 diabetes--related traits in mouse strains susceptible to diet-induced obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

A genome-wide association study identifies novel risk loci for type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Genetic basis of beta-cell dysfunction in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

The emerging genetics of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Genome-wide association studies in type 2 diabetes

21 January 2018

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https://api.crossref.org/works/10.1111%2FJOIM.12096

Production of pancreatic beta-cells from stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

21 January 2018

Islet cell development.

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Derivation of insulin-producing cells from human embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Efficient differentiation of human embryonic stem cells to definitive endoderm

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Mechanisms of beta-cell death in type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Bimodal effect on pancreatic β-cells of secretory products from normal or insulin-resistant human skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Glucolipotoxicity: fuel excess and beta-cell dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Identification of differentially expressed genes induced in pancreatic islet neogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Pancreatic acinar-to-beta cell transdifferentiation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Can beta-cells be derived from exocrine pancreas?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Ductal origin hypothesis of pancreatic regeneration under attack

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Intracellular signal transduction pathways that control pancreatic beta-cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Control of pancreatic β cell regeneration by glucose metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Disruption of IRS-2 causes type 2 diabetes in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Liver-derived systemic factors drive β cell hyperplasia in insulin-resistant states.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Regulation of pancreatic beta cell mass by neuronal signals from the liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Increased number of islet-associated macrophages in type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

FLIP switches Fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Adaptation of islets of Langerhans to pregnancy: beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Expansion of beta-cell mass in response to pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Effects of sex and pregnancy hormones on growth hormone and prolactin receptor gene expression in insulin-producing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Gestational diabetes mellitus resulting from impaired beta-cell compensation in the absence of FoxM1, a novel downstream effector of placental lactogen

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Participation of Akt, menin, and p21 in pregnancy-induced beta-cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Glucose-mediated repression of menin promotes pancreatic β-cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Serotonin regulates pancreatic beta cell mass during pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Placental lactogens induce serotonin biosynthesis in a subset of mouse beta cells during pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Finding genetic risk factors of gestational diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Risk factors for type 2 diabetes among women with gestational diabetes: a systematic review.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

cAMP-GEFII is a direct target of cAMP in regulated exocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Incretin-based therapies for type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Glucagon-like peptide 1 induces pancreatic beta-cell proliferation via transactivation of the epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Glucagon-like peptide-1 prevents beta cell glucolipotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Plasticity of the beta cell insulin secretory competence: preparing the pancreatic beta cell for the next meal

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Glucagon-like peptide-1 increases beta-cell glucose competence and proliferation by translational induction of insulin-like growth factor-1 receptor expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Prolonged remission of diabetes by regeneration of beta cells in diabetic mice treated with recombinant adenoviral vector expressing glucagon-like peptide-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Continuous stimulation of human glucagon-like peptide-1 (7-36) amide in a mouse model (NOD) delays onset of autoimmune type 1 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Glucagon-like peptide-1 protects beta-cells against apoptosis by increasing the activity of an IGF-2/IGF-1 receptor autocrine loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

In vitro proliferation of adult human beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Proliferation of sorted human and rat beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

One-year treatment with exenatide improves beta-cell function, compared with insulin glargine, in metformin-treated type 2 diabetic patients: a randomized, controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Increasing GLP-1-induced beta-cell proliferation by silencing the negative regulators of signaling cAMP response element modulator-alpha and DUSP14.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

PAS kinase: an evolutionarily conserved PAS domain-regulated serine/threonine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Per-arnt-sim (PAS) domain-containing protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

mTOR in aging, metabolism, and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

The role of mammalian target of rapamycin (mTOR) in the regulation of pancreatic β-cell mass: implications in the development of type-2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Activation of protein kinase C-ζ in pancreatic β-cells in vivo improves glucose tolerance and induces β-cell expansion via mTOR activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Role of the TSC1-TSC2 complex in the integration of insulin and glucose signaling involved in pancreatic beta-cell proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Critical roles for the TSC-mTOR pathway in β-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Rapamycin impairs beta-cell proliferation in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Are sirtuins viable targets for improving healthspan and lifespan?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

LKB1 deletion with the RIP2.Cre transgene modifies pancreatic beta-cell morphology and enhances insulin secretion in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

LKB1 regulates pancreatic beta cell size, polarity, and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Identification of a SIRT1 mutation in a family with type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

AMPK: a key sensor of fuel and energy status in skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Role of AMPK in pancreatic beta cell function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Obstacles on the way to the clinical visualisation of beta cells: looking for the Aeneas of molecular imaging to navigate between Scylla and Charybdis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Imaging of pancreatic islet cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

In vivo beta-cell imaging with VMAT 2 ligands--current state-of-the-art and future perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Gastric inhibitory polypeptide receptor, a member of the secretin- vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

Cellular composition of the human diabetic pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

7 January 2021

Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

7 January 2021

beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

7 January 2021

Sirtuins as regulators of metabolism and healthspan

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

7 January 2021

Regulation by Per-Arnt-Sim (PAS) kinase of pancreatic duodenal homeobox-1 nuclear import in pancreatic β-cells

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

7 January 2021

Tolbutamide stimulates proliferation of pancreatic beta cells in culture

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

7 January 2021

Compensatory Adaption to Partial Pancreatectomy in the Rat*

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

7 January 2021

Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

7 January 2021

Glucokinase, hexokinase, glucose transporter 2, and glucose metabolism in islets during pregnancy and prolactin-treated islets in vitro: mechanisms for long term up-regulation of islets

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

7 January 2021

Induction of nesidioblastosis will reverse diabetes in Syrian golden hamster

1 reference

https://api.crossref.org/works/10.1111%2FJOIM.12096

7 January 2021