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Genetically modified T cells for the treatment of malignant disease
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PubMed
title
Genetically modified T cells for the treatment of malignant disease
(English)
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PubMed
author name string
Agnieszka Wieczorek
series ordinal
1
1 reference
stated in
Crossref
Lutz Uharek
series ordinal
2
1 reference
stated in
Crossref
language of work or name
English
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stated in
PubMed
publication date
December 2013
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stated in
PubMed
published in
Transfusion Medicine and Hemotherapy
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stated in
PubMed
volume
40
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stated in
PubMed
issue
6
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stated in
PubMed
page(s)
388-402
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stated in
PubMed
cites work
T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia
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Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia
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Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen
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Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens
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Adoptive cell transfer: a clinical path to effective cancer immunotherapy
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Cancer regression in patients after transfer of genetically engineered lymphocytes
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Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes
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A human memory T cell subset with stem cell-like properties
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(Re)defining biopharmaceutical
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21 March 2017
B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells
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7 April 2017
Inducible apoptosis as a safety switch for adoptive cell therapy
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7 April 2017
Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1
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7 April 2017
Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2
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IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity
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Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias
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7 April 2017
T cells expressing chimeric antigen receptors can cause anaphylaxis in humans.
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PubMed Central
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28 September 2017
Identification of a Titin-derived HLA-A1-presented peptide as a cross-reactive target for engineered MAGE A3-directed T cells
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28 September 2017
Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma.
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28 September 2017
Manufacture of clinical-grade CD19-specific T cells stably expressing chimeric antigen receptor using Sleeping Beauty system and artificial antigen presenting cells
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Donor lymphocyte infusion for relapsed hematological malignancies after allogeneic hematopoietic cell transplantation: prognostic relevance of the initial CD3+ T cell dose
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28 September 2017
Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy
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28 September 2017
Sleeping beauty system to redirect T-cell specificity for human applications
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28 September 2017
Multi-cistronic vector encoding optimized safety switch for adoptive therapy with T-cell receptor-modified T cells
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28 September 2017
How do CARs work?: Early insights from recent clinical studies targeting CD19.
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28 September 2017
Comparison of different suicide-gene strategies for the safety improvement of genetically manipulated T cells.
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28 September 2017
On-target and off-target-based toxicologic effects
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28 September 2017
Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells
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28 September 2017
Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer
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28 September 2017
Improving TCR Gene Therapy for Treatment of Haematological Malignancies
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28 September 2017
The secret ally: immunostimulation by anticancer drugs
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28 September 2017
Chimeric antigen receptors for T cell immunotherapy: current understanding and future directions
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28 September 2017
Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma
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28 September 2017
Improving T-cell therapy for relapsed EBV-negative Hodgkin lymphoma by targeting upregulated MAGE-A4
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28 September 2017
CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients
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28 September 2017
Chimeric antigen receptor (CAR)-engineered lymphocytes for cancer therapy
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Enhancement of T-cell-mediated antitumor response: angiostatic adjuvant to immunotherapy against cancer.
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28 September 2017
Molecular determinants of immunogenic cell death elicited by anticancer chemotherapy
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28 September 2017
T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis.
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The SSX family of cancer-testis antigens as target proteins for tumor therapy
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Immune responses to transgene and retroviral vector in patients treated with ex vivo–engineered T cells
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28 September 2017
Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19
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Gene transfer efficiency and genome-wide integration profiling of Sleeping Beauty, Tol2, and piggyBac transposons in human primary T cells
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28 September 2017
Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor redirected T cells in humans
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28 September 2017
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28 September 2017
A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity
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28 September 2017
T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model.
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28 September 2017
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28 September 2017
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28 September 2017
Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells
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28 September 2017
Redirecting specificity of T-cell populations for CD19 using the Sleeping Beauty system
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28 September 2017
Enhanced functionality of T cell receptor-redirected T cells is defined by the transgene cassette
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28 September 2017
Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates
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28 September 2017
Leveraging the immune system during chemotherapy: moving calreticulin to the cell surface converts apoptotic death from "silent" to immunogenic
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28 September 2017
Enhanced antitumor activity of T cells engineered to express T-cell receptors with a second disulfide bond.
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28 September 2017
Engineered human tmpk/AZT as a novel enzyme/prodrug axis for suicide gene therapy.
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28 September 2017
Facilitating matched pairing and expression of TCR chains introduced into human T cells
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28 September 2017
A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer
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28 September 2017
Human T lymphocytes transduced by lentiviral vectors in the absence of TCR activation maintain an intact immune competence
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28 September 2017
Transduction of an IL-2 gene into human melanoma-reactive lymphocytes results in their continued growth in the absence of exogenous IL-2 and maintenance of specific antitumor activity
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28 September 2017
Genetic modification of human T cells with CD20: a strategy to purify and lyse transduced cells with anti-CD20 antibodies
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28 September 2017
Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity
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28 September 2017
Selective in Vitro Growth of T Lymphocytes from Normal Human Bone Marrows
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31 May 2018
Treatment of chronic lymphocytic leukemia with genetically targeted autologous T cells: case report of an unforeseen adverse event in a phase I clinical trial
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31 May 2018
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31 May 2018
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31 May 2018
IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors.
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28 November 2018
Lentiviral vector common integration sites in preclinical models and a clinical trial reflect a benign integration bias and not oncogenic selection
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28 November 2018
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28 November 2018
Adoptive immunotherapy with genetically engineered T cells: modification of the IgG1 Fc 'spacer' domain in the extracellular moiety of chimeric antigen receptors avoids 'off-target' activation and unintended initiation of an innate immune response
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28 November 2018
Minimal amino acid exchange in human TCR constant regions fosters improved function of TCR gene-modified T cells
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28 November 2018
T cell activation upon exposure to patient-derived tumor tissue: a functional assay to select patients for adoptive T cell therapy.
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28 November 2018
Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901623
retrieved
28 November 2018
Resistance of mature T cells to oncogene transformation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901623
retrieved
28 November 2018
Adoptive transfer of tumor-reactive transforming growth factor-beta-insensitive CD8+ T cells: eradication of autologous mouse prostate cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901623
retrieved
28 November 2018
HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3901623
retrieved
28 November 2018
Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24474888
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Efficient transfer of a tumor antigen-reactive TCR to human peripheral blood lymphocytes confers anti-tumor reactivity
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24474888
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: first clinical experience
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24474888
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Use of tumor-infiltrating lymphocytes and interleukin-2 in the immunotherapy of patients with metastatic melanoma. A preliminary report
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24474888
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Good T cells for bad B cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24474888
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Redirecting migration of T cells to chemokine secreted from tumors by genetic modification with CXCR2
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24474888
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Molecular design of the Calphabeta interface favors specific pairing of introduced TCRalphabeta in human T cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24474888
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24474888
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Prevention of interleukin-2 withdrawal-induced apoptosis in lymphocytes retrovirally cotransduced with genes encoding an antitumor T-cell receptor and an antiapoptotic protein
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24474888
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1159/000357163
1 reference
stated in
PubMed
PMC publication ID
3901623
1 reference
stated in
PubMed
PubMed publication ID
24474888
1 reference
stated in
PubMed
ResearchGate publication ID
259961174
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