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Designing synthetic vaccines for HIV
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PubMed
review article
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Europe PubMed Central
title
Designing synthetic vaccines for HIV
(English)
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stated in
PubMed
author
Barton Haynes
series ordinal
2
object named as
Barton F Haynes
1 reference
stated in
Crossref
Alberto Fernández-Tejada
series ordinal
1
object named as
Alberto Fernández-Tejada
1 reference
stated in
Crossref
author name string
Samuel J Danishefsky
series ordinal
3
1 reference
stated in
Crossref
language of work or name
English
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stated in
PubMed
publication date
June 2015
1 reference
stated in
PubMed
published in
Expert Review of Vaccines
1 reference
stated in
PubMed
volume
14
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stated in
PubMed
issue
6
1 reference
stated in
PubMed
page(s)
815-31
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stated in
PubMed
cites work
HIV-1 neutralizing antibodies: understanding nature's pathways
1 reference
stated in
PubMed Central
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21 March 2017
Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers
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PubMed Central
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21 March 2017
Antibody 8ANC195 Reveals a Site of Broad Vulnerability on the HIV-1 Envelope Spike
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PubMed Central
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21 March 2017
Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4693608
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21 March 2017
Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4693608
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21 March 2017
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
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21 March 2017
Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2
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21 March 2017
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4693608
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21 March 2017
A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4693608
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21 March 2017
A nonself sugar mimic of the HIV glycan shield shows enhanced antigenicity
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4693608
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21 March 2017
Antibody domain exchange is an immunological solution to carbohydrate cluster recognition
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4693608
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21 March 2017
Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand
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PubMed Central
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7 April 2017
Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target
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PubMed Central
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7 April 2017
Antibody neutralization and escape by HIV-1
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PubMed Central
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7 April 2017
Immune-correlates analysis of an HIV-1 vaccine efficacy trial
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PubMed Central
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7 April 2017
Broad neutralization coverage of HIV by multiple highly potent antibodies
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7 April 2017
Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies
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PubMed Central
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7 April 2017
The HIV-1 Envelope Glycoproteins: Fusogens, Antigens, and Immunogens
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7 April 2017
Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1
1 reference
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PubMed Central
reference URL
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7 April 2017
Structural evolution of glycan recognition by a family of potent HIV antibodies
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4693608
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28 September 2017
Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4693608
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28 September 2017
AIDS/HIV. Host controls of HIV neutralizing antibodies
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PubMed Central
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28 September 2017
Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers
1 reference
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PubMed Central
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28 September 2017
Vaccines that stimulate T cell immunity to HIV-1: the next step
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28 September 2017
Novel approaches in polyepitope T-cell vaccine development against HIV-1.
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28 September 2017
Recognition of synthetic glycopeptides by HIV-1 broadly neutralizing antibodies and their unmutated ancestors.
1 reference
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28 September 2017
Efficacy trial of a DNA/rAd5 HIV-1 preventive vaccine
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28 September 2017
Efficient convergent synthesis of bi-, tri-, and tetra-antennary complex type N-glycans and their HIV-1 antigenicity
1 reference
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PubMed Central
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28 September 2017
Synthetic glycopeptides reveal the glycan specificity of HIV-neutralizing antibodies.
1 reference
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PubMed Central
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28 September 2017
Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9.
1 reference
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PubMed Central
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28 September 2017
Characterization of host-cell line specific glycosylation profiles of early transmitted/founder HIV-1 gp120 envelope proteins
1 reference
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PubMed Central
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28 September 2017
Antigenicity and immunogenicity of RV144 vaccine AIDSVAX clade E envelope immunogen is enhanced by a gp120 N-terminal deletion
1 reference
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PubMed Central
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28 September 2017
Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses
1 reference
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PubMed Central
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28 September 2017
B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study
1 reference
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PubMed Central
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28 September 2017
The Thai phase III trial (RV144) vaccine regimen induces T cell responses that preferentially target epitopes within the V2 region of HIV-1 envelope
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4693608
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28 September 2017
New paradigms for HIV/AIDS vaccine development
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PubMed Central
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28 September 2017
The glycan shield of HIV is predominantly oligomannose independently of production system or viral clade.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4693608
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28 September 2017
Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestors
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4693608
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28 September 2017
Characterization of glycosylation profiles of HIV-1 transmitted/founder envelopes by mass spectrometry
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4693608
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28 September 2017
Induction of immunity to human immunodeficiency virus type-1 by vaccination
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PubMed Central
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28 September 2017
Phase III HIV vaccine trial in Thailand: a step toward a protective vaccine for HIV
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4693608
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28 September 2017
Variable loop glycan dependency of the broad and potent HIV-1-neutralizing antibodies PG9 and PG16.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4693608
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28 September 2017
Envelope glycans of immunodeficiency virions are almost entirely oligomannose antigens.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4693608
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28 September 2017
Defining criteria for oligomannose immunogens for HIV using icosahedral virus capsid scaffolds
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4693608
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28 September 2017
Neutralizing antibodies against HIV-1: can we elicit them with vaccines and how much do we need?
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PubMed Central
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28 September 2017
Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers
1 reference
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PubMed Central
reference URL
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28 September 2017
An oligosaccharide-based HIV-1 2G12 mimotope vaccine induces carbohydrate-specific antibodies that fail to neutralize HIV-1 virions
1 reference
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PubMed Central
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28 September 2017
A glycoconjugate antigen based on the recognition motif of a broadly neutralizing human immunodeficiency virus antibody, 2G12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120
1 reference
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PubMed Central
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28 September 2017
Targeting the carbohydrates on HIV-1: Interaction of oligomannose dendrons with human monoclonal antibody 2G12 and DC-SIGN
1 reference
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PubMed Central
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28 September 2017
Novel template-assembled oligosaccharide clusters as epitope mimics for HIV-neutralizing antibody 2G12. Design, synthesis, and antibody binding study
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PubMed Central
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28 September 2017
Dissection of the carbohydrate specificity of the broadly neutralizing anti-HIV-1 antibody 2G12.
1 reference
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PubMed Central
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28 September 2017
Oligosaccharide and glycoprotein microarrays as tools in HIV glycobiology; glycan-dependent gp120/protein interactions
1 reference
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PubMed Central
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28 September 2017
Binding of high-mannose-type oligosaccharides and synthetic oligomannose clusters to human antibody 2G12: implications for HIV-1 vaccine design
1 reference
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PubMed Central
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28 September 2017
Identifying epitopes of HIV-1 that induce protective antibodies
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PubMed Central
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28 September 2017
Reactivity-based one-pot synthesis of oligomannoses: defining antigens recognized by 2G12, a broadly neutralizing anti-HIV-1 antibody
1 reference
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PubMed Central
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28 September 2017
Design and synthesis of a template-assembled oligomannose cluster as an epitope mimic for human HIV-neutralizing antibody 2G12.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4693608
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28 September 2017
The discovery of HIV as the cause of AIDS.
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PubMed Central
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28 September 2017
The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1-->2 mannose residues on the outer face of gp120.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4693608
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28 September 2017
The mannose-dependent epitope for neutralizing antibody 2G12 on human immunodeficiency virus type 1 glycoprotein gp120.
1 reference
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28 September 2017
Viral persistence: HIV's strategies of immune system evasion
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28 September 2017
Mass spectrometric characterization of the glycosylation pattern of HIV-gp120 expressed in CHO cells
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PubMed Central
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28 September 2017
Promiscuous glycan site recognition by antibodies to the high-mannose patch of gp120 broadens neutralization of HIV.
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PubMed Central
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31 May 2018
Induction of HIV-1 broad neutralizing antibodies in 2F5 knock-in mice: selection against membrane proximal external region-associated autoreactivity limits T-dependent responses
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31 May 2018
Chemical synthesis of highly congested gp120 V1V2 N-glycopeptide antigens for potential HIV-1-directed vaccines
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31 May 2018
An advance in the chemical synthesis of homogeneous N-linked glycopolypeptides by convergent aspartylation
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31 May 2018
Yeast-elicited cross-reactive antibodies to HIV Env glycans efficiently neutralize virions expressing exclusively high-mannose N-linked glycans
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PubMed Central
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31 May 2018
Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection
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21 January 2018
In pursuit of carbohydrate-based HIV vaccines, part 1: The total synthesis of hybrid-type gp120 fragments
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21 January 2018
In pursuit of carbohydrate-based HIV vaccines, part 2: The total synthesis of high-mannose-type gp120 fragments--evaluation of strategies directed to maximal convergence
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21 January 2018
Toward fully synthetic carbohydrate-based HIV antigen design: on the critical role of bivalency
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21 January 2018
Toward a carbohydrate-based HIV-1 vaccine: synthesis and immunological studies of oligomannose-containing glycoconjugates
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21 January 2018
Free-radical-based, specific desulfurization of cysteine: a powerful advance in the synthesis of polypeptides and glycopolypeptides
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21 January 2018
Chemoenzymatic synthesis of HIV-1 V3 glycopeptides carrying two N-glycans and effects of glycosylation on the peptide domain
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21 January 2018
Immunology and the elusive AIDS vaccine
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21 January 2018
Clinical research. A setback and an advance on the AIDS vaccine front
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Fully Synthetic Carbohydrate HIV Antigens Designed on the Logic of the 2G12 Antibody
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25824661
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1586/14760584.2015.1027690
1 reference
stated in
PubMed
PMC publication ID
4693608
1 reference
stated in
PubMed
PubMed publication ID
25824661
1 reference
stated in
PubMed
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