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Redefining ALL classification: toward detecting high-risk ALL and implementing precision medicine
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PubMed
review article
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Europe PubMed Central
title
Redefining ALL classification: toward detecting high-risk ALL and implementing precision medicine
(English)
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PubMed
author
Charles G. Mullighan
series ordinal
2
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Europe PubMed Central
PMC publication ID
4481590
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25999453%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 June 2020
author name string
Stephen P Hunger
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
4481590
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25999453%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 June 2020
language of work or name
English
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PubMed
publication date
25 June 2015
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PubMed
published in
Blood
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PubMed
stated in
Europe PubMed Central
PMC publication ID
4481590
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25999453%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 June 2020
volume
125
2 references
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PubMed
stated in
Europe PubMed Central
PMC publication ID
4481590
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25999453%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 June 2020
issue
26
2 references
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PubMed
stated in
Europe PubMed Central
PMC publication ID
4481590
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25999453%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 June 2020
page(s)
3977-3987
1 reference
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Europe PubMed Central
PMC publication ID
4481590
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25999453%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 June 2020
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28 September 2017
Integrated use of minimal residual disease classification and IKZF1 alteration status accurately predicts 79% of relapses in pediatric acute lymphoblastic leukemia
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28 September 2017
Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome
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28 September 2017
Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia
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28 September 2017
Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia
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28 September 2017
Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia
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28 September 2017
Improved early event-free survival with imatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia: a children's oncology group study
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28 September 2017
WT1 mutations in T-ALL
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28 September 2017
JAK mutations in high-risk childhood acute lymphoblastic leukemia
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28 September 2017
High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481590
retrieved
28 September 2017
Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481590
retrieved
28 September 2017
Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481590
retrieved
28 September 2017
Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481590
retrieved
28 September 2017
Cytogenetics of paediatric and adolescent acute lymphoblastic leukaemia.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481590
retrieved
28 September 2017
Factors influencing survival after relapse from acute lymphoblastic leukemia: a Children's Oncology Group study
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481590
retrieved
28 September 2017
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481590
retrieved
28 September 2017
Outcome of treatment in children with hypodiploid acute lymphoblastic leukemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481590
retrieved
28 September 2017
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481590
retrieved
28 September 2017
NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481590
retrieved
28 September 2017
Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481590
retrieved
28 September 2017
The role of the Janus-faced transcription factor PAX5-JAK2 in acute lymphoblastic leukemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481590
retrieved
31 May 2018
Integrated genetic and epigenetic analysis of childhood acute lymphoblastic leukemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481590
retrieved
31 May 2018
Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481590
retrieved
31 May 2018
Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481590
retrieved
31 May 2018
ARID5B SNP rs10821936 is associated with risk of childhood acute lymphoblastic leukemia in blacks and contributes to racial differences in leukemia incidence
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481590
retrieved
31 May 2018
Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481590
retrieved
31 May 2018
An intragenic ERG deletion is a marker of an oncogenic subtype of B-cell precursor acute lymphoblastic leukemia with a favorable outcome despite frequent IKZF1 deletions.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481590
retrieved
28 November 2018
Risk-directed treatment intensification significantly reduces the risk of relapse among children and adolescents with acute lymphoblastic leukemia and intrachromosomal amplification of chromosome 21: a comparison of the MRC ALL97/99 and UKALL2003 tr
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481590
retrieved
28 November 2018
Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481590
retrieved
28 November 2018
Loss of chromosomes is the primary event in near-haploid and low-hypodiploid acute lymphoblastic leukemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481590
retrieved
28 November 2018
Highly sensitive MRD tests for ALL based on the IKZF1 Δ3-6 microdeletion
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481590
retrieved
28 November 2018
Genetic variegation of clonal architecture and propagating cells in leukaemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481590
retrieved
28 November 2018
Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481590
retrieved
28 November 2018
Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481590
retrieved
28 November 2018
BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481590
retrieved
28 November 2018
High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481590
retrieved
28 November 2018
Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481590
retrieved
28 November 2018
Presence of the P2RY8-CRLF2 rearrangement is associated with a poor prognosis in non-high-risk precursor B-cell acute lymphoblastic leukemia in children treated according to the ALL-BFM 2000 protocol
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25999453
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Clinical significance of early T-cell precursor acute lymphoblastic leukaemia: results of the Tokyo Children's Cancer Study Group Study L99-15
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25999453
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Outcome for children and young people with Early T-cell precursor acute lymphoblastic leukaemia treated on a contemporary protocol, UKALL 2003
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25999453
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Haploinsufficiency of the IKZF1 (IKAROS) tumor suppressor gene cooperates with BCR-ABL in a transgenic model of acute lymphoblastic leukemia
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25999453
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25999453
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Three distinct subgroups of hypodiploidy in acute lymphoblastic leukaemia
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25999453
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1182/BLOOD-2015-02-580043
2 references
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2641895
stated in
Europe PubMed Central
PMC publication ID
4481590
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25999453%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 June 2020
OpenCitations bibliographic resource ID
2641895
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2641895
PMC publication ID
4481590
2 references
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2641895
stated in
Europe PubMed Central
PMC publication ID
4481590
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25999453%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 June 2020
PubMed publication ID
25999453
2 references
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2641895
stated in
Europe PubMed Central
PMC publication ID
4481590
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25999453%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 June 2020
ResearchGate publication ID
277080465
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