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The genetic landscape of diffuse large B-cell lymphoma
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scholarly article
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stated in
PubMed
review article
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stated in
Europe PubMed Central
title
The genetic landscape of diffuse large B-cell lymphoma
(English)
1 reference
stated in
PubMed
main subject
B-cell lymphoma
1 reference
based on heuristic
inferred from title
diffuse large B-cell lymphoma
1 reference
based on heuristic
inferred from title
author
Riccardo Dalla-Favera
series ordinal
2
0 references
Laura Pasqualucci
series ordinal
1
0 references
language of work or name
English
1 reference
stated in
PubMed
publication date
April 2015
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stated in
PubMed
published in
Seminars in Hematology
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stated in
PubMed
volume
52
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stated in
PubMed
issue
2
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stated in
PubMed
page(s)
67-76
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stated in
PubMed
cites work
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Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing
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Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma
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Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma
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21 March 2017
Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways
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21 March 2017
Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma
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The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells
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21 March 2017
Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma
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Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)
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21 March 2017
Ongoing immunoglobulin somatic mutation in germinal center B cell-like but not in activated B cell-like diffuse large cell lymphomas
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PubMed Central
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21 March 2017
The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma
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Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
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PubMed Central
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21 March 2017
Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
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Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray
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21 March 2017
Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas
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PubMed Central
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21 March 2017
CBP/p300 in cell growth, transformation, and development
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21 March 2017
Oncogenically active MYD88 mutations in human lymphoma
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PubMed Central
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21 March 2017
Mutational analysis of PRDM1 indicates a tumor-suppressor role in diffuse large B-cell lymphomas
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PubMed Central
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21 March 2017
Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma
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PubMed Central
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21 March 2017
FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
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21 March 2017
Inactivating mutations of acetyltransferase genes in B-cell lymphoma
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PubMed Central
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7 April 2017
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
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PubMed Central
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7 April 2017
The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses
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7 April 2017
Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma
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PubMed Central
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Genetics of follicular lymphoma transformation
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28 September 2017
Diffuse large B-cell lymphoma-treatment approaches in the molecular era.
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28 September 2017
MEF2B mutations lead to deregulated expression of the oncogene BCL6 in diffuse large B cell lymphoma
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
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28 September 2017
EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
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28 September 2017
Analysis of FOXO1 mutations in diffuse large B-cell lymphoma
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
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28 September 2017
Recurrent targets of aberrant somatic hypermutation in lymphoma
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
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28 September 2017
The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
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28 September 2017
Integrative analysis reveals an outcome-associated and targetable pattern of p53 and cell cycle deregulation in diffuse large B cell lymphoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
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28 September 2017
Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
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28 September 2017
Roles of BCL6 in normal and transformed germinal center B cells
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
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28 September 2017
Germinal centers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
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28 September 2017
Combined genetic inactivation of β2-Microglobulin and CD58 reveals frequent escape from immune recognition in diffuse large B cell lymphoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
retrieved
28 September 2017
Analysis of the coding genome of diffuse large B-cell lymphoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
retrieved
28 September 2017
The molecular pathogenesis of primary mediastinal large B-cell lymphoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
retrieved
28 September 2017
Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
retrieved
28 September 2017
Constitutive canonical NF-κB activation cooperates with disruption of BLIMP1 in the pathogenesis of activated B cell-like diffuse large cell lymphoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
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28 September 2017
Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
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28 September 2017
BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
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28 September 2017
Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
retrieved
28 September 2017
Frequent inactivation of A20 in B-cell lymphomas
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
retrieved
28 September 2017
Oncogenic CARD11 mutations in human diffuse large B cell lymphoma
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
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28 September 2017
Germinal centres: role in B-cell physiology and malignancy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
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28 September 2017
Distinctive patterns of BCL6 molecular alterations and their functional consequences in different subgroups of diffuse large B-cell lymphoma
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
retrieved
28 September 2017
BCL6 programs lymphoma cells for survival and differentiation through distinct biochemical mechanisms
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
retrieved
28 September 2017
Aberrant immunoglobulin class switch recombination and switch translocations in activated B cell-like diffuse large B cell lymphoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
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28 September 2017
Mechanisms of MHC class I-restricted antigen processing and cross-presentation
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
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28 September 2017
CARMA1, BCL-10 and MALT1 in lymphocyte development and activation.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
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28 September 2017
Negative autoregulation of BCL-6 is bypassed by genetic alterations in diffuse large B cell lymphomas
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
retrieved
28 September 2017
Acetylation inactivates the transcriptional repressor BCL6.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
retrieved
28 September 2017
ATM mutations are associated with inactivation of the ARF-TP53 tumor suppressor pathway in diffuse large B-cell lymphoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
retrieved
28 September 2017
Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
retrieved
28 September 2017
Mechanisms of chromosomal translocations in B cell lymphomas
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
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28 September 2017
BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
retrieved
28 September 2017
Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
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31 May 2018
Hierarchy in somatic mutations arising during genomic evolution and progression of follicular lymphoma
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
retrieved
31 May 2018
BLIMP1 is a tumor suppressor gene frequently disrupted in activated B cell-like diffuse large B cell lymphoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
retrieved
31 May 2018
The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
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28 November 2018
Two levels of protection for the B cell genome during somatic hypermutation.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
retrieved
28 November 2018
AID is required for germinal center-derived lymphomagenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
retrieved
28 November 2018
A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
retrieved
28 November 2018
Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
retrieved
28 November 2018
AID is required for c-myc/IgH chromosome translocations in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
retrieved
28 November 2018
Blimp-1 Is Required for the Formation of Immunoglobulin Secreting Plasma Cells and Pre-Plasma Memory B Cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
retrieved
28 November 2018
The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
retrieved
28 November 2018
Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
retrieved
28 November 2018
Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646421
retrieved
28 November 2018
Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25805586
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1053/J.SEMINHEMATOL.2015.01.005
0 references
PMC publication ID
4646421
1 reference
stated in
PubMed
PubMed publication ID
25805586
1 reference
stated in
PubMed
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