(Q36926825)

17 August 2017

EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation (English)

1 reference

17 August 2017

32

Olivier Elemento

0 references

Leandro Cerchietti

28

Leandro Cerchietti

0 references

Yupeng Zheng

Yupeng Zheng

13

0 references

Omar Abdel-Wahab

Omar Abdel-Wahab

30

0 references

Randy D Gascoyne

26

Randy D Gascoyne

1 reference

17 August 2017

Wendy Béguelin

1

1 reference

17 August 2017

Relja Popovic

2

1 reference

17 August 2017

Matt Teater

3

1 reference

17 August 2017

Yanwen Jiang

4

1 reference

17 August 2017

Karen L Bunting

5

1 reference

17 August 2017

Monica Rosen

6

1 reference

17 August 2017

Hao Shen

7

1 reference

17 August 2017

Shao Ning Yang

8

1 reference

17 August 2017

Ling Wang

9

1 reference

17 August 2017

Teresa Ezponda

10

1 reference

17 August 2017

Eva Martinez-Garcia

11

1 reference

17 August 2017

Haikuo Zhang

12

1 reference

17 August 2017

Sharad K Verma

14

1 reference

17 August 2017

Michael T McCabe

15

1 reference

17 August 2017

Heidi M Ott

16

1 reference

17 August 2017

Glenn S Van Aller

17

1 reference

17 August 2017

Ryan G Kruger

18

1 reference

17 August 2017

Yan Liu

19

1 reference

17 August 2017

Charles F McHugh

20

1 reference

17 August 2017

David W Scott

21

1 reference

17 August 2017

Young Rock Chung

22

1 reference

17 August 2017

Neil Kelleher

23

1 reference

17 August 2017

Rita Shaknovich

24

1 reference

17 August 2017

Caretha L Creasy

25

1 reference

17 August 2017

Kwok-Kin Wong

27

1 reference

17 August 2017

Ross L Levine

29

1 reference

17 August 2017

Jonathan D Licht

31

1 reference

17 August 2017

Ari M Melnick

33

1 reference

17 August 2017

1 May 2013

1 reference

17 August 2017

1 reference

17 August 2017

23

1 reference

17 August 2017

5

1 reference

17 August 2017

677-692

1 reference

Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2.

17 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

Aberration in DNA methylation in B-cell lymphomas has a complex origin and increases with disease severity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

The role of mutations in epigenetic regulators in myeloid malignancies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

Global gene expression analysis of very small embryonic-like stem cells reveals that the Ezh2-dependent bivalent domain mechanism contributes to their pluripotent state.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

Malignant pirates of the immune system

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

Silencing of Kruppel-like factor 2 by the histone methyltransferase EZH2 in human cancer.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

An integrated ChIP-seq analysis platform with customizable workflows

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

Aberrations of EZH2 in cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

TopHat: discovering splice junctions with RNA-Seq

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

B-cell lymphoma 6 and the molecular pathogenesis of diffuse large B-cell lymphoma.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

Mapping and quantifying mammalian transcriptomes by RNA-Seq

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

Germinal centres: role in B-cell physiology and malignancy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

Integrative genomics analysis reveals silencing of beta-adrenergic signaling by polycomb in prostate cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

Histone methyltransferase activity of a Drosophila Polycomb group repressor complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

Role of histone H3 lysine 27 methylation in Polycomb-group silencing

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

Chromatin silencing and activation by Polycomb and trithorax group proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

The polycomb-group gene Ezh2 is required for early mouse development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

Distinct expression patterns of polycomb oncoproteins and their binding partners during the germinal center reaction

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

Cutting edge: polycomb gene expression patterns reflect distinct B cell differentiation stages in human germinal centers.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

VavP-Bcl2 transgenic mice develop follicular lymphoma preceded by germinal center hyperplasia

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681809

Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice

4 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23680150

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A model system for peptide hormone action in differentiation: interleukin 2 induces a B lymphoma to transcribe the J chain gene

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23680150

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CCR.2013.04.011

1 reference

release_4jd6ar7hqzccbjnxvc63r6vani

17 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/4jd6ar7hqzccbjnxvc63r6vani

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

17 August 2017

1 reference