(Q34302726)

1 August 2017

title

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells (English)

1 reference

1 August 2017

Joelle D Sacks

7

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ORCID Public Data File 2021

author name string

Sarah K Knutson

1

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1 August 2017

Tim J Wigle

2

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1 August 2017

Natalie M Warholic

3

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1 August 2017

Christopher J Sneeringer

4

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1 August 2017

Christina J Allain

5

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1 August 2017

Christine R Klaus

6

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1 August 2017

Alejandra Raimondi

8

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1 August 2017

Christina R Majer

9

1 reference

1 August 2017

Jeffrey Song

10

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1 August 2017

Margaret Porter Scott

11

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1 August 2017

Lei Jin

12

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1 August 2017

Jesse J Smith

13

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1 August 2017

Edward J Olhava

14

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1 August 2017

Richard Chesworth

15

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1 August 2017

Mikel P Moyer

16

1 reference

1 August 2017

Victoria M Richon

17

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1 August 2017

Robert A Copeland

18

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1 August 2017

Heike Keilhack

19

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1 August 2017

Roy M Pollock

20

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1 August 2017

Kevin W Kuntz

21

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1 August 2017

language of work or name

1 reference

30 September 2012

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1 August 2017

published in

Nature Chemical Biology

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1 August 2017

volume

8

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1 August 2017

issue

11

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1 August 2017

page(s)

890-896

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Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein

1 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1084

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UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development

21 January 2018

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Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases

21 January 2018

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Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination

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A histone H3 lysine 27 demethylase regulates animal posterior development

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The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing

21 January 2018

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EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

21 January 2018

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The polycomb group protein EZH2 is involved in progression of prostate cancer

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Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27.

21 January 2018

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EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer

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EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis

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A novel human homologue of Drosophila polycomblike gene is up-regulated in multiple cancers.

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Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

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Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

21 January 2018

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Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

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Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)

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DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation.

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Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells

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Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2)

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Structural basis of EZH2 recognition by EED

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Role of the polycomb protein EED in the propagation of repressive histone marks

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Chemogenetic analysis of human protein methyltransferases

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Improved survival with vemurafenib in melanoma with BRAF V600E mutation

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The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states

21 January 2018

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Protein methyltransferases as a target class for drug discovery

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A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

21 January 2018

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Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

21 January 2018

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21 January 2018

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Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

21 January 2018

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21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23023262

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

STUDIES ON LIVER ALCOHOL HYDROGENASE COMPLEXES. 3. MULTIPLE INHIBITION KINETICS IN THE PRESENCE OF TWO COMPETITIVE INHIBITORS

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23023262

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCHEMBIO.1084

1 reference

Dimensions Publication ID

1 August 2017

1024506073

0 references

1 reference